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NeoBiotechnologies
Desmocollin-2/3 Monoclonal Antibody (7G6)
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Product Details
1824-MSM1-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
7G6
Immunogen
Human desmocollin-2 extracellular domain
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Wet ice
Target Information
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARVC10; ARVD10; Cadherin family member 2; Cadherin family member 3; CDHF5; CDHF6; CMD1BB; Desmocollin-2; Desmocollin-3; Desmocollin-4; desmoglein-2; desmoglein-3; Desmosomal glycoprotein II; desmosomal glycoprotein II/III; Desmosomal glycoprotein III; Epithelial type 2 desmocollin; HDGC; HT-CP; PVA
Gene Aliases: 5430426I24Rik; ARVD11; AW228162; CDHF2; CDHF3; DG2; DGII/III; DSC; DSC1; DSC2; Dsc2a; Dsc2b; DSC3; DSC4; HT-CP
UniProt ID: (Human) Q02487, (Human) Q14574, (Mouse) P55292, (Mouse) P55850
Entrez Gene ID: (Human) 1824, (Human) 1825, (Rat) 291760, (Mouse) 13506, (Mouse) 13507, (Rat) 307563
homophilic cell adhesion via plasma membrane adhesion molecules
cellular response to starvation
ventricular cardiac muscle cell action potential
cardiac muscle cell-cardiac muscle cell adhesion
bundle of His cell to Purkinje myocyte communication
regulation of heart rate by cardiac conduction
cell adhesion
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of ventricular cardiac muscle cell action potential
in utero embryonic development
protein stabilization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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