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Invitrogen
Desmoglein 2 Polyclonal Antibody
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FIGURE: 1 / 13
Desmoglein 2 Antibody (PA5-21444) in ICC/IF
Desmoglein 2 Polyclonal Antibody detects Desmoglein 2 protein at cell membrane by immunofluorescent analysis. Sample: A431 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Desmoglein 2 stained by Desmoglein 2 Polyclonal Antibody (Product # PA5-21444) diluted at 1:500. Blue: Fluoroshield with DAPI .
Product Details
PA5-21444
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Extracellular domain of human Desmoglein 2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.36 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11152315
Product Specific Information
Recommended positive controls: HeLa, 293T, H1299, Molt-4.
Predicted reactivity: Mouse (87%), Bovine (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ARVC10; ARVD10; Cadherin family member 5; CMD1BB; Desmoglein-2; DSG-2; HDGC; MGC117034; MGC117036; MGC117037
Gene Aliases: AA408168; CDHF5; D18Ertd293e; DSG2; HDGC
UniProt ID: (Human) Q14126, (Mouse) O55111
Entrez Gene ID: (Human) 1829, (Mouse) 13511
desmosome organization
Purkinje myocyte development
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
response to progesterone
maternal process involved in female pregnancy
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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