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Desmoplakin Antibody (PA5-142588) in IHC (P)
Immunohistochemistry analysis of Desmoplakin in human heart. Samples were incubated with Desmoplakin polyclonal antibody (Product # PA5-142588) using a dilution of 3.75 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-142588
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-QESVKQAHLRNEH.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2933234
Product Specific Information
Additional Information: This antibody is expected to recognize reported isoform I (NP_004406.2) only.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000.
Preliminary analysis showed no signal in Western Blot.
Target Information
Desmoplakin (DSP) is a major high molecular weight protein of the desmosomes. It is involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Desmoplakin mutations are associated with Keratoderma and cardiomyopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; Desmoplakin II; Desmoplakin-I; DP
Gene Aliases: DCWHKTA; DP; DSP
UniProt ID: (Human) P15924
Entrez Gene ID: (Human) 1832
protein kinase C binding
structural molecule activity
structural constituent of cytoskeleton
protein binding
protein binding, bridging
poly(A) RNA binding
cell adhesion molecule binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
scaffold protein binding
desmosome organization
ventricular compact myocardium morphogenesis
epidermis development
peptide cross-linking
keratinocyte differentiation
adherens junction organization
wound healing
intermediate filament organization
protein localization to adherens junction
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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