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Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
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Protein Aliases: DHP; DHPase; Dihydropyrimidinase; Dihydropyrimidine amidohydrolase; Hydantoinase
Gene Aliases: 1200017I10Rik; 1300004I01Rik; DHP; DHPase; DPYS
UniProt ID: (Human) Q14117, (Rat) Q63150, (Mouse) Q9EQF5
Entrez Gene ID: (Human) 1807, (Rat) 65135, (Mouse) 64705
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