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Invitrogen
Dopamine beta Hydroxylase Polyclonal Antibody
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Product Details
PA3-925
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues S(43) E P P E S P F P Y H I P L D P E G T L(62) of rat DBH.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2089215
Product Specific Information
PA3-925 detects human, bovine, rat and mouse DBH. This antibody is not effective for immunohistochemistry in human brain.
PA3-925 has been successfully used in Western blot, immunohistochemistry and immunofluorescence procedures. By Western blot, this antibody detects an ~72 kDa protein representing DBH from rat neurons. In immunohistochemistry and immunofluorescence procedures, it specifically stains chromaffin cells of the adrenal medulla, and DBH containing cells of the sympathetic nervous system.
The PA3-925 immunogen is a synthetic peptide corresponding to residues S(43) E P P E S P F P Y H I P L D P E G T L(62) of rat DBH. This sequence is highly conserved (>85% homology) in human, bovine and mouse.
Target Information
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Dopamine beta hydroxylase (dopamine beta-monooxygenase); Dopamine beta-hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); Dopamine beta-monooxygenase; Dopamine-Beta-hydroxylase
Gene Aliases: BOS_12212; DBH; DBM; DOPBHY
UniProt ID: (Human) P09172, (Bovine) P15101, (Rat) Q05754, (Mouse) Q64237
Entrez Gene ID: (Human) 1621, (Bovine) 280758, (Rat) 25699, (Mouse) 13166
catalytic activity
dopamine beta-monooxygenase activity
copper ion binding
L-ascorbic acid binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
monooxygenase activity
oxidoreductase activity
metal ion binding
cytokine production
blood vessel remodeling
response to amphetamine
leukocyte mediated immunity
catecholamine metabolic process
memory
locomotory behavior
associative learning
visual learning
response to iron ion
response to ozone
multicellular organism aging
response to organic cyclic compound
response to estradiol
social behavior
response to isolation stress
response to immobilization stress
regulation of cell proliferation
homoiothermy
dopamine catabolic process
norepinephrine biosynthetic process
response to drug
glucose homeostasis
fear response
maternal behavior
response to peptide hormone
response to ethanol
positive regulation of vasoconstriction
octopamine metabolic process
response to copper ion
behavioral response to ethanol
response to pain
leukocyte migration
sensory perception of taste
oxidation-reduction process
bone development
cellular response to manganese ion
cellular response to nicotine
regulation of extrinsic apoptotic signaling pathway
chemical synaptic transmission
catecholamine biosynthetic process
regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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