Proteintech

Drebrin Polyclonal Antibody

Drebrin Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 5

Drebrin Antibody (10260-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 10260-1-AP (Drebrin antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Drebrin Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10260-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

Assay-dependent

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

1:20-1:200

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Drebrin Fusion Protein Ag0371 (118-302 aa encoded by BC000283)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ASSVEDIDA GAIGQRLSNG LARLSSPVLH RLRLREDENA EPVGTTYQKT DAAVEMKRIN REQFWEQAKK EEELRKEEER KKALDERLRF EQERMEQERQ EQEERERRYR EREQQIEEHR RKQQTLEAEE AKRRLKEQSI FGDHRDEEEE THMKKSESEV EEAAAIIAQR PDNPREFFKQ QERVAS (118-302 aa encoded by BC000283)

Target Information

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis.

Nature cell biology

Liu X,Nie L,Zhang Y,Yan Y,Wang C,Colic M,Olszewski K,Horbath A,Chen X,Lei G,Mao C,Wu S,Zhuang L,Poyurovsky MV,James You M,Hart T,Billadeau DD,Chen J,Gan B

Wed Mar 01 00:00:00 UTC 2023

Exposure to bisphenol A induces neurotoxicity associated with synaptic and cytoskeletal dysfunction in neuro-2a cells.

Toxicology and industrial health

Wang S,Ning H,Wang X,Chen L,Hua L,Ren F,Hu D,Li R,Ma Z,Ge Y,Yin Z

Thu Jun 01 00:00:00 UTC 2023

ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice.

Frontiers in endocrinology

Song L,Chen H,Qiao D,Zhang B,Guo F,Zhang Y,Wang C,Li S,Cui H

Thu Jun 22 00:00:00 UTC 2023

ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice.

Frontiers in endocrinology

Song L,Chen H,Qiao D,Zhang B,Guo F,Zhang Y,Wang C,Li S,Cui H

Thu Jun 22 00:00:00 UTC 2023

Intron retention is a stress response in sensor genes and is restored by Japanese herbal medicines: A basis for future clinical applications.

Gene

Vu TD,Ito N,Oshima K,Maruko A,Nishi A,Mizoguchi K,Odaguchi H,Kobayashi Y,Okada N

Fri Jul 01 00:00:00 UTC 2022

Endocannabinoids regulate cocaine-associated memory through brain AEA-CB1R signalling activation.

Molecular metabolism

Li H,Chen R,Zhou Y,Wang H,Sun L,Yang Z,Bai L,Zhang J

Tue Nov 01 00:00:00 UTC 2022

Drebrin promotes lung adenocarcinoma cell migration through inducing integrin β1 endocytosis.

Biochemical and biophysical research communications

Yu Q,Tang F,Cao F,Tan X,Weng L,Sun L

Sat Nov 19 00:00:00 UTC 2022

Drebrin promotes lung adenocarcinoma cell migration through inducing integrin β1 endocytosis.

Biochemical and biophysical research communications

Yu Q,Tang F,Cao F,Tan X,Weng L,Sun L

Sat Nov 19 00:00:00 UTC 2022

Acute lead acetate induces neurotoxicity through decreased synaptic plasticity-related protein expression and disordered dendritic formation in nerve cells.

Environmental science and pollution research international

Chen L,Liu Y,Jia P,Zhang H,Yin Z,Hu D,Ning H,Ge Y

Mon Aug 01 00:00:00 UTC 2022

Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA.

Cell death discovery

Zhang R,Zhang Y,Guo F,Huang G,Zhao Y,Chen B,Wang C,Cui C,Shi Y,Li S,Cui H

Fri Oct 28 00:00:00 UTC 2022

Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA.

Cell death discovery

Zhang R,Zhang Y,Guo F,Huang G,Zhao Y,Chen B,Wang C,Cui C,Shi Y,Li S,Cui H

Fri Oct 28 00:00:00 UTC 2022

L-3-n-Butylphthalide improves synaptic and dendritic spine plasticity and ameliorates neurite pathology in Alzheimer's disease mouse model and cultured hippocampal neurons.

Molecular neurobiology

Huang L,Lan J,Tang J,Kang Y,Feng X,Wu L,Peng Y

Mon Mar 01 00:00:00 UTC 2021

Drebrin Regulates Acetylcholine Receptor Clustering and Organization of Microtubules at the Postsynaptic Machinery.

International journal of molecular sciences

Alvarez-Suarez P,Nowak N,Protasiuk-Filipunas A,Yamazaki H,Prószyński TJ,Gawor M

Mon Aug 30 00:00:00 UTC 2021

Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells.

Toxicology in vitro : an international journal published in association with BIBRA

Yin Z,Hua L,Chen L,Hu D,Li J,An Z,Tian T,Ning H,Ge Y

Tue Sep 01 00:00:00 UTC 2020

Cadmium induces actin cytoskeleton alterations and dysfunction in Neuro-2a cells.

Environmental toxicology

Ge Y,Song X,Chen L,Hu D,Hua L,Cui Y,Liu J,An Z,Yin Z,Ning H

Mon Apr 01 00:00:00 UTC 2019

Cadmium induces actin cytoskeleton alterations and dysfunction in Neuro-2a cells.

Environmental toxicology

Ge Y,Song X,Chen L,Hu D,Hua L,Cui Y,Liu J,An Z,Yin Z,Ning H

Mon Apr 01 00:00:00 UTC 2019

Label-free quantitative mass spectrometry analysis of differential protein expression in the developing cochlear sensory epithelium.

Proteome science

Darville LNF,Sokolowski BHA

Fri Mar 18 00:00:00 UTC 2022

Label-free quantitative mass spectrometry analysis of differential protein expression in the developing cochlear sensory epithelium.

Proteome science

Darville LNF,Sokolowski BHA

Fri Mar 18 00:00:00 UTC 2022

N-wasp is required for structural integrity of the blood-testis barrier.

PLoS genetics

Xiao X,Mruk DD,Tang EI,Massarwa R,Mok KW,Li N,Wong CK,Lee WM,Snapper SB,Shilo BZ,Schejter ED,Cheng CY

Sun Jun 01 00:00:00 UTC 2014

N-wasp is required for structural integrity of the blood-testis barrier.

PLoS genetics

Xiao X,Mruk DD,Tang EI,Massarwa R,Mok KW,Li N,Wong CK,Lee WM,Snapper SB,Shilo BZ,Schejter ED,Cheng CY

Sun Jun 01 00:00:00 UTC 2014

Contribution of single-minded 2 to hyperglycaemia-induced neurotoxicity.

Neurotoxicology

Wang X,Song Y,Chen L,Zhuang G,Zhang J,Li M,Meng XF

Fri Mar 01 00:00:00 UTC 2013

Contribution of single-minded 2 to hyperglycaemia-induced neurotoxicity.

Neurotoxicology

Wang X,Song Y,Chen L,Zhuang G,Zhang J,Li M,Meng XF

Fri Mar 01 00:00:00 UTC 2013

Contribution of single-minded 2 to hyperglycaemia-induced neurotoxicity.

Neurotoxicology

Wang X,Song Y,Chen L,Zhuang G,Zhang J,Li M,Meng XF

Fri Mar 01 00:00:00 UTC 2013

Contribution of single-minded 2 to hyperglycaemia-induced neurotoxicity.

Neurotoxicology

Wang X,Song Y,Chen L,Zhuang G,Zhang J,Li M,Meng XF

Fri Mar 01 00:00:00 UTC 2013

Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis.

Spermatogenesis

Li MW,Xiao X,Mruk DD,Lam YL,Lee WM,Lui WY,Bonanomi M,Silvestrini B,Cheng CY

Thu Oct 21 00:00:00 UTC 2021

Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis.

Spermatogenesis

Li MW,Xiao X,Mruk DD,Lam YL,Lee WM,Lui WY,Bonanomi M,Silvestrini B,Cheng CY

Thu Oct 21 00:00:00 UTC 2021

Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis.

Spermatogenesis

Li MW,Xiao X,Mruk DD,Lam YL,Lee WM,Lui WY,Bonanomi M,Silvestrini B,Cheng CY

Thu Oct 21 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: Developmentally-regulated brain protein; DKFZp434D064; Drebrin; drebrin A; drebrin E; drebrin E2; drebrin-1

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Gene Aliases: D0S117E; DBN1; Drba

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UniProt ID: (Human) Q16643, (Rat) Q07266, (Mouse) Q9QXS6

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Entrez Gene ID: (Human) 1627, (Rat) 81653, (Mouse) 56320

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Function(s)

actin binding protein binding profilin binding cadherin binding involved in cell-cell adhesion

Process(es)

actin filament organization nervous system development cell communication by chemical coupling cell communication by electrical coupling maintenance of protein location in cell generation of neurons neural precursor cell proliferation multicellular organism development cell differentiation regulation of neuronal synaptic plasticity regulation of dendrite development cell-cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Drebrin Polyclonal Antibody

Drebrin Antibody (10260-1-AP) in ICC/IF

Product Details

10260-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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