Proteintech

Dystrophin Polyclonal Antibody

Dystrophin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Dystrophin Antibody (12715-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using 12715-1-AP ( Dystrophin antibody at dilution of 1:200 (under 10x lens).

Dystrophin Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Dystrophin Antibody in Western Blot (WB)

Dystrophin Antibody in Immunoprecipitation (IP)

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Product Details

12715-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 11 publications 11 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Dystrophin Fusion Protein Ag3408 (286-635 aa encoded by BC028720)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YPMVEYCTP TTSGEDVRDF AKVLKNKFRT KRYFAKHPRM GYLPVQTVLE GDNMETPVTL INFWPVDSAP ASSPQLSHDD THSRIEHYAS RLAEMENSNG SYLNDSISPN ESIDDEHLLI QHYCQSLNQD SPLSQPRSPA QILISLESEE RGELERILAD LEEENRNLQA EYDRLKQQHE HKGLSPLPSP PEMMPTSPQS PRDAELIAEA KLLRQHKGRL EARMQILEDH NKQLESQLHR LRQLLEQPQA EAKVNGTTVS SPSTSLQRSD SSQPMLLRVV GSQTSDSMGE EDLLSPPQDT STGLEEVMEQ LNNSFPSSRG HNVGSLFHMA DDLGRAMESL VSVMTDEEGA E (286-635 aa encoded by BC028720)

Target Information

Dystrophin is the 427kDa protein product of the DMB/BMD gene located on the X chromosome at position Xp21. Western blotting and immunohistochemistry are the two established methods for the detection of abnormalities of dystrophin expression in muscle biopsies. Dystrophin abnormalities are thought to occur in 100% of patients with DMD/BMD, although genetic abnormalities may only be detected in up to 65% of cases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons.

Molecular neurobiology

Fujimoto T,Stam K,Yaoi T,Nakano K,Arai T,Okamura T,Itoh K

Sat Jul 01 00:00:00 UTC 2023

Evaluation of Cardiac Function in Young Mdx Mice Using MRI with Feature Tracking and Self-Gated Magnetic Resonance Cine Imaging.

Diagnostics (Basel, Switzerland)

Ueda J,Saito S

Wed Apr 19 00:00:00 UTC 2023

Adeno-associated viral delivery of engineered tRNA-enzyme pairs into nonsense mutation mouse models.

STAR protocols

Zheng Z,Shi N,Xia Q

Fri Mar 17 00:00:00 UTC 2023

Muscle cytotoxicity and immuno-reactivity analysis of the porous carbon nanospheres fabricated by high temperature calcination.

Nanomedicine : nanotechnology, biology, and medicine

Huang J,Jian X,Xu M,Wang H,Liao Z,Lan H,Wang L,Hu J,Yu Q,Liao H

Wed Feb 01 00:00:00 UTC 2023

Restoration of dystrophin expression in mice by suppressing a nonsense mutation through the incorporation of unnatural amino acids.

Nature biomedical engineering

Shi N,Yang Q,Zhang H,Lu J,Lin H,Yang X,Abulimiti A,Cheng J,Wang Y,Tong L,Wang T,Zhang X,Chen H,Xia Q

Tue Feb 01 00:00:00 UTC 2022

Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders.

Science advances

El Andari J,Renaud-Gabardos E,Tulalamba W,Weinmann J,Mangin L,Pham QH,Hille S,Bennett A,Attebi E,Bourges E,Leborgne C,Guerchet N,Fakhiri J,Krämer C,Wiedtke E,McKenna R,Guianvarc'h L,Toueille M,Ronzitti G,Hebben M,Mingozzi F,VandenDriessche T,Agbandje-McKenna M,Müller OJ,Chuah MK,Buj-Bello A,Grimm D

Fri Sep 23 00:00:00 UTC 2022

Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders.

Science advances

Fri Sep 23 00:00:00 UTC 2022

Two-dimensional speckle tracking echocardiography demonstrates improved myocardial function after intravenous infusion of bone marrow mesenchymal stem in the X-Linked muscular dystrophy mice.

BMC cardiovascular disorders

Liu X,Yao S,Pan M,Cai Y,Shentu W,Cai W,Yu H

Thu Nov 03 00:00:00 UTC 2022

Embryonic stem cell-derived mesenchymal stem cells alleviate skeletal muscle injury induced by acute compartment syndrome.

Stem cell research & therapy

Jiang X,Yang J,Liu F,Tao J,Xu J,Zhang M

Fri Jul 15 00:00:00 UTC 2022

Amyloids facilitate DNA transfection in vivo.

Neuroscience research

Imamura Y,Hiyama A,Miyazaki H,Yamanaka T,Nukina N

Fri Jul 01 00:00:00 UTC 2022

Human umbilical cord-derived mesenchymal stromal cells ameliorate aging-associated skeletal muscle atrophy and dysfunction by modulating apoptosis and mitochondrial damage in SAMP10 mice.

Stem cell research & therapy

Piao L,Huang Z,Inoue A,Kuzuya M,Cheng XW

Fri Jun 03 00:00:00 UTC 2022

Liraglutide Improves the Angiogenic Capability of EPC and Promotes Ischemic Angiogenesis in Mice under Diabetic Conditions through an Nrf2-Dependent Mechanism.

Cells

Yan X,Su Y,Fan X,Chen H,Lu Z,Liu Z,Li Y,Yi M,Zhang G,Gu C,Wang K,Wu J,Sun D,Zhang Y,Zhang C,Dai X,Zheng C

Tue Nov 29 00:00:00 UTC 2022

Dystrophin deficiency affects human astrocyte properties and response to damage.

Glia

Lange J,Gillham O,Alkharji R,Eaton S,Ferrari G,Madej M,Flower M,Tedesco FS,Muntoni F,Ferretti P

Tue Mar 01 00:00:00 UTC 2022

Knockdown of Salusin-β Improves Cardiovascular Function in Myocardial Infarction-Induced Chronic Heart Failure Rats.

Oxidative medicine and cellular longevity

Xu Y,Pan Y,Wang X,Chen A,Tang X,Liu X,Han Y

Tue Jan 11 00:00:00 UTC 2022

FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+-dependent manner.

Journal of cellular and molecular medicine

Dai Q,Fan X,Meng X,Sun S,Su Y,Ling X,Chen X,Wang K,Dai X,Zhang C,Da S,Zhang G,Gu C,Chen H,He J,Hu H,Yu L,Pan X,Tan Y,Yan X

Mon Mar 01 00:00:00 UTC 2021

Targeting the Ang2/Tie2 Axis with Tanshinone IIA Elicits Vascular Normalization in Ischemic Injury and Colon Cancer.

Oxidative medicine and cellular longevity

Zou W,Qian C,Zhang S,Wan X,Wei Z,Li X,Wu Y,Chen W,Wang A,Zhao Y,Lu Y

Tue Feb 08 00:00:00 UTC 2022

Protective Effects of Rocuronium Bromide on Ischemia-Reperfusion Injury in Skeletal Muscle Induced by Tourniquet in Patients Undergoing Elective Unilateral Total Knee Arthroplasty: A Prospective, Double Blind, Randomized, Controlled Study.

Drug design, development and therapy

Chen H,Wei JQ,Wang YW,Zhou KP,He Y,Liu H,Zhang YY

Fri Jul 02 00:00:00 UTC 2021

Dystroglycan regulates proper expression, submembranous localization and subsequent phosphorylation of Dp71 through physical interaction.

Human molecular genetics

Fujimoto T,Yaoi T,Tanaka H,Itoh K

Wed Nov 25 00:00:00 UTC 2020

Dystroglycan regulates proper expression, submembranous localization and subsequent phosphorylation of Dp71 through physical interaction.

Human molecular genetics

Fujimoto T,Yaoi T,Tanaka H,Itoh K

Wed Nov 25 00:00:00 UTC 2020

Dystroglycan regulates proper expression, submembranous localization and subsequent phosphorylation of Dp71 through physical interaction.

Human molecular genetics

Fujimoto T,Yaoi T,Tanaka H,Itoh K

Wed Nov 25 00:00:00 UTC 2020

The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells.

American journal of physiology. Endocrinology and metabolism

Fujimoto BA,Young M,Carter L,Pang APS,Corley MJ,Fogelgren B,Polgar N

Sun Dec 01 00:00:00 UTC 2019

New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.

Journal of neuroinflammation

Liu WT,Lv YJ,Yang RC,Fu JY,Liu L,Wang H,Cao Q,Tan C,Chen HC,Wang XR

Fri Oct 19 00:00:00 UTC 2018

New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.

Journal of neuroinflammation

Liu WT,Lv YJ,Yang RC,Fu JY,Liu L,Wang H,Cao Q,Tan C,Chen HC,Wang XR

Fri Oct 19 00:00:00 UTC 2018

Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.

Nature communications

Lu IL,Chen C,Tung CY,Chen HH,Pan JP,Chang CH,Cheng JS,Chen YA,Wang CH,Huang CW,Kang YN,Chang HY,Li LL,Chang KP,Shih YH,Lin CH,Kwan SY,Tsai JW

Wed Jun 27 00:00:00 UTC 2018

Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.

Nature communications

Lu IL,Chen C,Tung CY,Chen HH,Pan JP,Chang CH,Cheng JS,Chen YA,Wang CH,Huang CW,Kang YN,Chang HY,Li LL,Chang KP,Shih YH,Lin CH,Kwan SY,Tsai JW

Wed Jun 27 00:00:00 UTC 2018

Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.

Nature communications

Lu IL,Chen C,Tung CY,Chen HH,Pan JP,Chang CH,Cheng JS,Chen YA,Wang CH,Huang CW,Kang YN,Chang HY,Li LL,Chang KP,Shih YH,Lin CH,Kwan SY,Tsai JW

Wed Jun 27 00:00:00 UTC 2018

Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.

Nature communications

Lu IL,Chen C,Tung CY,Chen HH,Pan JP,Chang CH,Cheng JS,Chen YA,Wang CH,Huang CW,Kang YN,Chang HY,Li LL,Chang KP,Shih YH,Lin CH,Kwan SY,Tsai JW

Wed Jun 27 00:00:00 UTC 2018

Dp71 is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells.

Biochemical and biophysical research communications

Fujimoto T,Yaoi T,Fushiki S,Itoh K

Sat Oct 21 00:00:00 UTC 2017

Dp71 is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells.

Biochemical and biophysical research communications

Fujimoto T,Yaoi T,Fushiki S,Itoh K

Sat Oct 21 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: apodystrophin-3; apodystrophin-I; Duchenne muscular dystrophy (DMD); Dystrophin; dystrophin Dp40; dystrophin Dp71a; dystrophin Dp71ab; dystrophin Dp71b; dystrophin, muscular dystrophy; GS1-19O24.1; Muscular dystrophy Duchenne and Becker types; OTTHUMP00000215592; X-linked muscular dystrophy

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Gene Aliases: BMD; CMD3B; DMD; DNADMD1; Dp427; Dp71; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; DXSmh7; DXSmh9; dys; mdx; MRX85; pke

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UniProt ID: (Human) P11532, (Mouse) P11531

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Entrez Gene ID: (Human) 1756, (Mouse) 13405, (Rat) 24907

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Function(s)

dystroglycan binding actin binding structural constituent of cytoskeleton protein binding zinc ion binding structural constituent of muscle myosin binding vinculin binding nitric-oxide synthase binding metal ion binding integrin binding PDZ domain binding protein complex binding

Process(es)

positive regulation of cell-matrix adhesion regulation of heart rate regulation of transcription, DNA-templated muscle organ development skeletal muscle tissue development establishment of blood-nerve barrier regulation of gene expression regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of neuron projection development regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of skeletal muscle contraction myotube cell development muscle attachment olfactory nerve structural organization negative regulation of peptidyl-serine phosphorylation cellular protein localization response to muscle stretch regulation of membrane potential peptide biosynthetic process cellular protein complex assembly neurotransmitter receptor metabolic process positive regulation of neuron differentiation muscle cell cellular homeostasis muscle fiber development nucleus localization cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity establishment of glial blood-brain barrier negative regulation of ERK1 and ERK2 cascade cardiac muscle cell action potential regulation of cellular response to growth factor stimulus regulation of voltage-gated calcium channel activity negative regulation of peptidyl-cysteine S-nitrosylation positive regulation of sodium ion transmembrane transporter activity aging cell differentiation muscle cell differentiation neuron projection morphogenesis cytoskeleton organization muscle filament sliding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Dystrophin Polyclonal Antibody

Dystrophin Antibody (12715-1-AP) in IHC (P)

Product Details

12715-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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