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Invitrogen
E-cadherin Monoclonal Antibody (7A2)
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Product Details
MA5-15717
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
7A2
Immunogen
Purified recombinant fragment of human CDH1 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10985271
Product Specific Information
MA5-15717 targets CDH1 in indirect ELISA, WB applications and shows reactivity with Human, mouse, and Non-human primate samples.
The MA5-15717 immunogen is purified recombinant fragment of human CDH1 expressed in E. Coli.
MA5-15717 detects CDH1 which has a predicted molecular weight of approximately 135kDa.
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARC-1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; Cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; cell-CAM 120/80; E-Cadherin; E-cadherin 1; Ecadherin; Epithelial cadherin; Uvomorulin
Gene Aliases: AA960649; Arc-1; CD324; CDH1; CDHE; E-cad; ECAD; L-CAM; LCAM; Um; UVO
UniProt ID: (Human) P12830, (Mouse) P09803, (Rat) Q9R0T4
Entrez Gene ID: (Human) 999, (Mouse) 12550, (Rat) 83502
glycoprotein binding
calcium ion binding
protein binding
beta-catenin binding
ankyrin binding
GTPase activating protein binding
gamma-catenin binding
cell adhesion molecule binding
cadherin binding involved in cell-cell adhesion
protein phosphatase binding
protein domain specific binding
metal ion binding
in utero embryonic development
trophectodermal cell differentiation
epithelial cell morphogenesis
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
synapse assembly
sensory perception of sound
single organismal cell-cell adhesion
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
protein metabolic process
negative regulation of cell-cell adhesion
regulation of protein localization
regulation of water loss via skin
adherens junction organization
positive regulation of transcription factor import into nucleus
regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of transcription, DNA-templated
regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
protein homooligomerization
intestinal epithelial cell development
salivary gland cavitation
regulation of branching involved in salivary gland morphogenesis
bicellular tight junction assembly
cellular response to amino acid stimulus
cellular response to lithium ion
cellular response to indole-3-methanol
protein localization to plasma membrane
establishment of protein localization to plasma membrane
negative regulation of canonical Wnt signaling pathway
cochlea development
regulation of protein localization to cell surface
regulation of neuron migration
response to toxic substance
response to organic substance
pituitary gland development
neuron projection development
response to drug
extracellular matrix disassembly
extracellular matrix organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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