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Invitrogen
E2F4/E2F5 Polyclonal Antibody
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Product Details
PA5-36051
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 18-72 of human E2F4
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2553346
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 44 kDa.
Purity is >95% by SDS-PAGE.
Target Information
E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 is a member of a broader family of transcriptional regulators including E2F-2, E2F-3, E2F-4, E2F-5 and E2F-6, each of which forms heterodimers with a second protein, DP-1, forming an "active" E2F transcriptional regulatory complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E2F transcription factor 4, p107/p130-binding; E2F transcription factor 5, p130-binding; E2F-4; E2F-5; p107/p130-binding protein; Transcription factor E2F4; Transcription factor E2F5
Gene Aliases: 2010111M04Rik; AI427446; AU024671; E2F-4; E2F-5; E2F4; E2F5
UniProt ID: (Human) Q16254, (Human) Q15329, (Mouse) Q8R0K9, (Mouse) Q61502
Entrez Gene ID: (Human) 1874, (Human) 1875, (Rat) 100360427, (Mouse) 104394, (Mouse) 13559, (Rat) 116651
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
promoter-specific chromatin binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
sequence-specific DNA binding
transcription, DNA-templated
organ morphogenesis
cell projection organization
positive regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
epithelial cell development
transcription from RNA polymerase II promoter
cell volume homeostasis
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
blood circulation
regulation of cell proliferation
motile cilium assembly
centriole assembly
multi-ciliated epithelial cell differentiation
regulation of cell size
cilium assembly
mitotic cell cycle
regulation of transcription, DNA-templated
cell cycle
G1/S transition of mitotic cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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