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Proteintech
EAAT4 Polyclonal Antibody
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Product Details
12876-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EAAT4 Fusion Protein Ag3554 (149-271 aa encoded by BC028721)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes 60-70 kDa of EAAT4 in mouse brain and several other lysate.
Immunogen sequence: MVTIIHPGK GSKEGLHREG RIETIPTADA FMDLIRNMFP PNLVEACFKQ FKTQYSTRVV TRTMVRTENG SEPGASMPPP FSVENGTSFL ENVTRALGTL QEMLSFEETV PVPGSANGIN ALGL (149-271 aa encoded by B C028721)
Target Information
Slc1a6 encodes a protein that is a glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution. Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Slc1a6 functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Slc1a6 also mediates Cl(-) flux that is not coupled to amino acid transport and this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Further, Slc1a6 [lays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable). Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Excitatory amino acid transporter 4; high affinity aspartate/glutamate transporter; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6; Solute carrier family 1 member 6; solute carrier family 1, member 6
Gene Aliases: EAAT4; SLC1A6
UniProt ID: (Human) P48664, (Rat) O35921, (Mouse) O35544
Entrez Gene ID: (Human) 6511, (Rat) 84012, (Mouse) 20513
amino acid transmembrane transport
ion transport
chemical synaptic transmission
glutamate secretion
aspartate transport
L-glutamate transport
regulation of membrane potential
L-glutamate transmembrane transport
L-aspartate transmembrane transport
anion transmembrane transport
transport
dicarboxylic acid transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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