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Invitrogen
ECT2 Monoclonal Antibody (OTI2D9)
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ECT2 Antibody (MA5-26870) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human ovary tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a ECT2 monoclonal antibody (Product # MA5-26870).
Product Details
MA5-26870
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2D9
Immunogen
Human recombinant protein fragment corresponding to amino acids 175-438 of ECT2 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723111
Target Information
The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epithelial cell transforming sequence 2 oncogene; Epithelial cell-transforming sequence 2 oncogene; FLJ10461; MGC138291; Protein ECT2
Gene Aliases: ARHGEF31; ECT2
UniProt ID: (Human) Q9H8V3
Entrez Gene ID: (Human) 1894
cell morphogenesis
cytokinesis
protein transport
activation of protein kinase activity
positive regulation of cytokinesis
regulation of Rho protein signal transduction
intracellular signal transduction
positive regulation of protein import into nucleus
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of GTPase activity
positive regulation of neuron differentiation
regulation of protein kinase activity
regulation of small GTPase mediated signal transduction
protein homooligomerization
regulation of attachment of spindle microtubules to kinetochore
cellular response to hydrogen peroxide
bicellular tight junction assembly
cellular response to calcium ion
cellular response to ionizing radiation
activation of GTPase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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