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Product Details
H00001896-M08
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
4B3
Immunogen
EDA (NP_001390.1, 245 a.a. approximately 391 a.a) partial recombinant protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: ENQPAVVHLQ GQGSAIQVKN DLSGGVLNDW SRITMNPKVF KLHPRSGELE VLVDGTYFIY SQVEVYYINF TDFASYEVVV DEKPFLQCTR SIETGKTNYN TCYTAGVCLL KARQKIAVKM VHADISINMS KHTTFFGAIR LGEAPAS
Target Information
EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. This protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in the gene for EDA are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ectodermal dysplasia protein; Ectodysplasin; Ectodysplasin-A; EDA 1; EDA protein; oligodontia 1; tumor necrosis factor ligand 7C; X-linked anhidroitic ectodermal dysplasia protein
Gene Aliases: ECTD1; ED1; ED1-A1; ED1-A2; EDA; EDA-A1; EDA-A2; EDA1; EDA2; HED; HED1; ODT1; STHAGX1; TNLG7C; XHED; XLHED
UniProt ID: (Human) Q92838
Entrez Gene ID: (Human) 1896
immune response
cell-matrix adhesion
gene expression
positive regulation of gene expression
cell differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of NF-kappaB import into nucleus
odontogenesis of dentin-containing tooth
pigmentation
positive regulation of NF-kappaB transcription factor activity
salivary gland cavitation
hair follicle placode formation
trachea gland development
positive regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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