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Proteintech
EDAR Polyclonal Antibody
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Product Details
18032-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EDAR Fusion Protein Ag12601 (207-448 aa encoded by BC093872)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MFYILKTKP SAPACCTSHP GKSVEAQVSK DEEKKEAPDN VVMFSEKDEF EKLTATPAKP TKSENDASSE NEQLLSRSVD SDEEPAPDKQ GSPELCLLSL VHLAREKSAT SNKSAGIQSR RKKILDVYAN VCGVVEGLSP TELPFDCLEK TSRMLSSTYN SEKAVVKTWR HLAESFGLKR DEIGGMTDGM QLFDRISTAG YSIPELLTKL VQIERLDAVE SLCADILEWA GVVPPASQPH AAS (207-448 aa encoded by BC093872)
Target Information
This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Anhidrotic ectodysplasin receptor 1; Downless homolog; downless, mouse, homolog of; Ectodermal dysplasia receptor; ectodysplasin 1, anhidrotic receptor; Ectodysplasin-A receptor; EDA-A1 receptor; Tumor necrosis factor receptor superfamily member EDAR
Gene Aliases: DL; ECTD10A; ECTD10B; ED1R; ED3; ED5; EDA-A1R; EDA1R; EDA3; EDAR; HRM1
UniProt ID: (Human) Q9UNE0
Entrez Gene ID: (Human) 10913
hair follicle development
apoptotic process
epidermis development
positive regulation of gene expression
cell differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of NF-kappaB import into nucleus
odontogenesis of dentin-containing tooth
positive regulation of I-kappaB kinase/NF-kappaB signaling
pigmentation
positive regulation of JNK cascade
salivary gland cavitation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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