Rockland

EGR-1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

600-401-693

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500- 1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

2-20 µg/mL
-

ELISA (ELISA)

1:4,000-1:16,000
-

Immunoprecipitation (IP)

1:500-1:3,000
-
Product Specifications

Species Reactivity

Chimpanzee, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 85-115 of Human EGR-1.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.93 mg/mL

Purification

Affinity chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This affinity purified antibody is directed against human EGR-1 protein. A BLAST analysis was used to suggest reactivity with this protein from human and chimpanzee sources based on 100% homology for the immunogen sequence. This antibody is expected to cross react with EGR-1.

Target Information

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AT225; Early growth response protein 1; EGR-1; Krox-24 nuclear protein; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24

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Gene Aliases: A530045N19Rik; AT225; egr; Egr-1; EGR1; ETR103; G0S30; Krox-1; KROX-24; KROX24; NGF1-A; NGFI-A; NGFIA; TIS8; Zenk; Zfp-6; ZIF-268; Zif268; ZNF225

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UniProt ID: (Human) P18146, (Mouse) P08046

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Entrez Gene ID: (Human) 1958, (Mouse) 13653

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding histone acetyltransferase binding sequence-specific DNA binding metal ion binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding nucleic acid binding double-stranded DNA binding transcription factor binding transcription regulatory region DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter response to glucose T cell differentiation BMP signaling pathway response to insulin regulation of protein sumoylation skeletal muscle cell differentiation regulation of apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter type I interferon signaling pathway regulation of transcription from RNA polymerase II promoter in response to hypoxia interleukin-1-mediated signaling pathway cellular response to gamma radiation cellular response to heparin cellular response to mycophenolic acid glomerular mesangial cell proliferation positive regulation of glomerular metanephric mesangial cell proliferation negative regulation of canonical Wnt signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated learning or memory positive regulation of gene expression positive regulation of cell death negative regulation of apoptotic process positive regulation of neuron apoptotic process regulation of long-term neuronal synaptic plasticity cellular response to organic substance cellular response to cAMP cellular response to gonadotropin stimulus
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