Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Abnova
EGR2 Monoclonal Antibody (1G5)
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
H00001959-M03
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
1G5
Immunogen
EGR2 (NP_000390.2, 217 a.a. approximately 293 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: PGLFPMIPDY PGFFPSQCQR DLHGTAGPDR KPFPCPLDTL RVPPPLTPLS TIRNFTLGGP SAGVTGPGAS GGSEGPR
Target Information
The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins. These proteins bind to specific areas of DNA and help control the activity of particular genes. On the basis of this action, the proteins are referred to as transcription factors. The early growth response 2 protein activates several genes that are involved in the formation and maintenance of myelin, the fatty substance that covers and protects nerve cells. Myelin promotes the efficient transmission of nerve impulses. If myelin is lost (demyelination) or its structure is disrupted, the transmission of nerve impulses is impaired. Mutations in the EGR2 gene can cause two forms of Charcot-Marie-Tooth disease, type 1D or type 4E (sometimes called congenital hypomyelinating neuropathy) or a severe form of type 1D (sometimes called Dejerine-Sottas syndrome) that begins during infancy or early childhood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: AT591; DKFZp686J1957; E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; Early growth response protein 2; EGR-2; FLJ1454; FLJ14547; Krox-20 homolog; KROX-20, Drosophila, homolog (early growth response-2); OTTHUMP00000062133; Zinc finger protein Krox-20
Gene Aliases: AT591; CMT1D; CMT4E; Egr-2; EGR2; Krox-20; KROX20
UniProt ID: (Human) P11161, (Rat) P51774
Entrez Gene ID: (Human) 1959, (Rat) 114090
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
ligase activity
ubiquitin protein ligase binding
transcription regulatory region DNA binding
metal ion binding
HMG box domain binding
DNA binding
transcription from RNA polymerase II promoter
protein export from nucleus
brain development
peripheral nervous system development
learning or memory
rhythmic behavior
motor neuron axon guidance
Schwann cell differentiation
protein sumoylation
facial nerve structural organization
rhombomere 3 formation
rhombomere 5 formation
regulation of ossification
response to insulin
brain segmentation
skeletal muscle cell differentiation
myelination
fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of neuronal synaptic plasticity
cellular response to organic substance
regulation of transcription, DNA-templated
rhombomere 3 development
negative regulation of apoptotic process
cellular response to cAMP
cellular response to gonadotropin stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support