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Immunogen sequence: LEISDEFSE AIGALRGHED KIRVVLNKAD MVETQQLMRV YGALMWALGK VVGTPEVLRV YIGSFWSQPL LVPDNRRLFE LEEQDLFRDI QGLPRHAALR KLNDLVKRAR LVRVHAYIIS YLKKEMPSVF GKENKKKQLI LKLPVIFAKI QLEHHISPGD FPDCQKMQEL LMAHDFTKFH SLKPKLLEAL DEMLTHDIAK LMPLLRQEEL ESTEVGVQGG AFEGTHMGPF VERGPDEAME DGEEGSDDEA EWVVTKDKSK YDEIFYNLAP ADGKLSGSKA KTWMVGTKLP NSVLGRIWKL SDVDRDGMLD DEEFALASHL IEAKLEGHGL PANLPRRLVP PSKRRHKGSA E (194-543 aa encoded by BC014445)
This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EH domain-containing protein 2; EH-domain containing 2; FLJ96617; PAST homolog 2; putative eps protein
Gene Aliases: BC027084; C130052H20Rik; EHD2; MGEPS; PAST2
UniProt ID: (Human) Q9NZN4, (Rat) Q4V8H8, (Mouse) Q8BH64
Entrez Gene ID: (Human) 30846, (Rat) 361512, (Mouse) 259300
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