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Proteintech
EIF3A Polyclonal Antibody
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Product Details
26178-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EIF3A Fusion Protein Ag22515 (1033-1382 aa encoded by BC114429)
Conjugate
Form
Liquid
Concentration
0.44 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DEDRGPRRG MDDDRGPRRG GADDERSSWR NADDDRGPRR GLDDDRGPRR GMDDDRGPRR GMDDDRGPRR GMDDDRGPRR GLDDDRGPWR NADDDRIPRR GAEDDRGPWR NMDDDRLSRR ADDDRFPGRG DDSRPGPWRP LVKPGGWREK EKAREESWGP PRESRPSEER EWDREKERDR DNQDREENDK DPERERDRER DVDREDRFRR PRDEGGWRRG PAEESSSWRD SSRRDDRDRD DRRRERDDRR DLRERRDLRD DRDRRGPPLR SEREEVSSWR RADDRKDDRV EERDPPRRVP PPALSRDRER DRDREREGEK EKASWRAEKD RESLRRTKNE TDEDGWTTVR R (1033-1382 aa encoded by BC114429)
Target Information
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 150/170; centrosomin homolog; cytoplasmic protein p167; eIF-3-theta; eIF3 p167; eIF3 p180; eIF3 p185; EIF3, p180 subunit; EIF3A; Eukaryotic translation initiation factor 3 subunit 10; Eukaryotic translation initiation factor 3 subunit A; eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD); eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD); eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa; eukaryotic translation initiation factor 3, subunit 10, 170kD; eukaryotic translation initiation factor 3, subunit A
Gene Aliases: EIF3; eIF3-p170; eIF3-theta; EIF3A; EIF3S10; KIAA0139; P167; p180; p185; TIF32
UniProt ID: (Human) Q14152
Entrez Gene ID: (Human) 8661
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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