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Product Details
CL488-67719
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1B11A10
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SVAGEYGRHS LYKMLGYFSL VGLLRLHSLL GDYYQAIKVL ENIELNKKSM YSRVPECQVT TYYYVGFAYL MMRRYQDAIR VFANILLYIQ RTKSMFQRTT YKYEMINKQN EQMHALLAIA LTMYPMRIDE SIHLQLREKY GDKMLRMQKG DPQVYEELFS YSCPKFLSPV VPNYDNVHPN YHKEPFLQQL KVFSDEVQQQ AQLSTIRSFL KLYTTMPVAK LAGFLDLTEQ EFRIQLLVFK HKMKNLVWTS GISALDGEFQ SASEVDFYID KDMIHIADTK VARRYGDFFI RQIHKFEELN RTLKKMGQRP
Target Information
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 66 kDa tyrosine-rich heat shock protein; 67 kDa polymerase-associated factor; eIEF associated protein HSPC021; EIF3L; Eukaryotic translation initiation factor 3 subunit 6-interacting protein; Eukaryotic translation initiation factor 3 subunit E-interacting protein; Eukaryotic translation initiation factor 3 subunit L; eukaryotic translation initiation factor 3, subunit 6 interacting protein; eukaryotic translation initiation factor 3, subunit L; HSP-66Y; PAF67
Gene Aliases: 0610011H21Rik; D15N1e; EIF3EIP; Eif3ip; EIF3L; EIF3S11; EIF3S6IP; HSP-66Y; HSPC021; HSPC025; MSTP005; PAF67
UniProt ID: (Human) Q9Y262, (Mouse) Q8QZY1
Entrez Gene ID: (Human) 51386, (Mouse) 223691, (Rat) 300069
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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