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EIF5A2 Polyclonal Antibody

EIF5A2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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EIF5A2 Antibody (17069-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using (Product # 17069-1-AP) (EIF5A1/EIF5A2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

EIF5A2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17069-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EIF5A2 Fusion Protein Ag10895 (1-153 aa encoded by BC036072)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MADEIDFTT GDAGASSTYP MQCSALRKNG FVVLKGRPCK IVEMSTSKTG KHGHAKVHLV GIDIFTGKKY EDICPSTHNM DVPNIKRNDY QLICIQDGYL SLLTETGEVR EDLKLPEGEL GKEIEGKYNA GEDVQVSVMC AMSEEYAVAI KPCK (1-153 aa encoded by BC036072)

Target Information

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

High eukaryotic initiation factor 5A2 expression predicts poor prognosis and may participate in the SNHG16/miR-10b-5p/EIF5A2 regulatory axis in head and neck squamous cell carcinoma.

Journal of clinical laboratory analysis

Ye S,Wang D,Jin M,Du J,Chen X,Zhang H,Zhou C,Fang S,Liu K

Sun Jan 01 00:00:00 UTC 2023

Eukaryotic Initiation Factor 5A2 Regulates Expression of Antiviral Genes.

Journal of molecular biology

Farache D,Liu L,Lee ASY

Mon May 30 00:00:00 UTC 2022

Global analyses of mRNA expression in human sensory neurons reveal eIF5A as a conserved target for inflammatory pain.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chase R,de la Peña JB,Smith PR,Lawson J,Lou TF,Stanowick AD,Black BJ,Campbell ZT

Fri Jul 01 00:00:00 UTC 2022

Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.

PLoS biology

Ma D,Zheng B,Liu HL,Zhao YB,Liu X,Zhang XH,Li Q,Shi WB,Suzuki T,Wen JK

Sat Aug 01 00:00:00 UTC 2020

Knockdown of EIF5A2 inhibits the malignant potential of non-small cell lung cancer cells.

Oncology letters

Chen C,Zhang B,Wu S,Song Y,Li J

Sun Apr 01 00:00:00 UTC 2018

Knockdown of EIF5A2 inhibits the malignant potential of non-small cell lung cancer cells.

Oncology letters

Chen C,Zhang B,Wu S,Song Y,Li J

Sun Apr 01 00:00:00 UTC 2018

Knockdown of EIF5A2 inhibits the malignant potential of non-small cell lung cancer cells.

Oncology letters

Chen C,Zhang B,Wu S,Song Y,Li J

Sun Apr 01 00:00:00 UTC 2018

Knockdown of EIF5A2 inhibits the malignant potential of non-small cell lung cancer cells.

Oncology letters

Chen C,Zhang B,Wu S,Song Y,Li J

Sun Apr 01 00:00:00 UTC 2018

EIF5A2 is a novel chemoresistance gene in breast cancer.

Breast cancer (Tokyo, Japan)

Liu Y,Du F,Chen W,Yao M,Lv K,Fu P

Sun Nov 01 00:00:00 UTC 2015

EIF5A2 is a novel chemoresistance gene in breast cancer.

Breast cancer (Tokyo, Japan)

Liu Y,Du F,Chen W,Yao M,Lv K,Fu P

Sun Nov 01 00:00:00 UTC 2015

Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2.

BMC pulmonary medicine

Xu G,Yu H,Shi X,Sun L,Zhou Q,Zheng D,Shi H,Li N,Zhang X,Shao G

Fri Nov 07 00:00:00 UTC 2014

Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2.

BMC pulmonary medicine

Xu G,Yu H,Shi X,Sun L,Zhou Q,Zheng D,Shi H,Li N,Zhang X,Shao G

Fri Nov 07 00:00:00 UTC 2014

Down-regulation of eIF5A-2 prevents epithelial-mesenchymal transition in non-small-cell lung cancer cells.

Journal of Zhejiang University. Science. B

Xu GD,Shi XB,Sun LB,Zhou QY,Zheng DW,Shi HS,Che YL,Wang ZS,Shao GF

Sat Jun 01 00:00:00 UTC 2013

Down-regulation of eIF5A-2 prevents epithelial-mesenchymal transition in non-small-cell lung cancer cells.

Journal of Zhejiang University. Science. B

Xu GD,Shi XB,Sun LB,Zhou QY,Zheng DW,Shi HS,Che YL,Wang ZS,Shao GF

Sat Jun 01 00:00:00 UTC 2013

Novel functional MAR elements of double minute chromosomes in human ovarian cells capable of enhancing gene expression.

PloS one

Jin Y,Liu Z,Cao W,Ma X,Fan Y,Yu Y,Bai J,Chen F,Rosales J,Lee KY,Fu S

Mon Sep 24 00:00:00 UTC 2012

Novel functional MAR elements of double minute chromosomes in human ovarian cells capable of enhancing gene expression.

PloS one

Jin Y,Liu Z,Cao W,Ma X,Fan Y,Yu Y,Bai J,Chen F,Rosales J,Lee KY,Fu S

Mon Sep 24 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: eIF-5A-2; eIF-5A2; eukaryotic initiation factor 5A; Eukaryotic initiation factor 5A isoform 2; Eukaryotic translation initiation factor 5A-2

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Gene Aliases: 9630038B20; EIF-5A2; EIF5A2; eIF5AII

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UniProt ID: (Human) Q9GZV4, (Mouse) Q8BGY2

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Entrez Gene ID: (Human) 56648, (Rat) 310261, (Mouse) 208691

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Function(s)

translation elongation factor activity protein binding ribosome binding translation initiation factor activity RNA binding

Process(es)

translational initiation translational frameshifting positive regulation of cell proliferation positive regulation of translational elongation positive regulation of translational termination translation translational elongation transport protein transport mRNA transport spermatogenesis peptidyl-lysine modification to peptidyl-hypusine polyamine homeostasis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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EIF5A2 Polyclonal Antibody

EIF5A2 Antibody (17069-1-AP) in IHC (P)

Product Details

17069-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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