Proteintech

ELAVL2 Polyclonal Antibody

ELAVL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

ELAVL2 Antibody (14008-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human brain using 14008-1-AP (ELAVL2 antibody) at dilution of 1:100 (under 40x lens).

ELAVL2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14008-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

RNA Immunoprecipitation (RIP)

View 3 publications 3 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Chicken, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ELAVL2 Fusion Protein Ag5105 (5-346 aa encoded by BC030692)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LSNGPTCNN TANGPTTINN NCSSPVDSGN TEDSKTNLIV NYLPQNMTQE ELKSLFGSIG EIESCKLVRD KITGQSLGYG FVNYIDPKDA EKAINTLNGL RLQTKTIKVS YARPSSASIR DANLYVSGLP KTMTQKELEQ LFSQYGRIIT SRILVDQVTG ISRGVGFIRF DKRIEAEEAI KGLNGQKPPG ATEPITVKFA NNPSQKTNQA ILSQLYQSPN RRYPGPLAQQ AQRFRFSPMT IDGMTSLAGI NIPGHPGTGW CIFVYNLAPD ADESILWQMF GPFGAVTNVK VIRDFNTNKC KGFGFVTMTN YDEAAMAIAS LNGYRLGDRV LQVSFKTNKT HKA (5-346 aa encoded by BC030692)

Target Information

The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.

iScience

Hsu YH,Pintacuda G,Liu R,Nacu E,Kim A,Tsafou K,Petrossian N,Crotty W,Suh JM,Riseman J,Martin JM,Biagini JC,Mena D,Ching JKT,Malolepsza E,Li T,Singh T,Ge T,Egri SB,Tanenbaum B,Stanclift CR,Apffel AM,Carr SA,Schenone M,Jaffe J,Fornelos N,Huang H,Eggan KC,Lage K

Fri May 19 00:00:00 UTC 2023

Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.

Cell genomics

Pintacuda G,Hsu YH,Tsafou K,Li KW,Martín JM,Riseman J,Biagini JC,Ching JKT,Mena D,Gonzalez-Lozano MA,Egri SB,Jaffe J,Smit AB,Fornelos N,Eggan KC,Lage K

Wed Mar 08 00:00:00 UTC 2023

Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons.

Development (Cambridge, England)

De Gregorio R,Subah G,Chan JC,Speranza L,Zhang X,Ramakrishnan A,Shen L,Maze I,Stanton PK,Sze JY

Tue Nov 01 00:00:00 UTC 2022

The SYNGAP1 3'UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Yokoi S,Ito T,Sahashi K,Nakatochi M,Nakamura R,Tohnai G,Fujioka Y,Ishigaki S,Udagawa T,Izumi Y,Morita M,Kano O,Oda M,Sone T,Okano H,Atsuta N,Katsuno M,Okada Y,Sobue G

Wed Nov 23 00:00:00 UTC 2022

Dihydroartemisinin Attenuates Hypoxia-Induced Pulmonary Hypertension Through the ELAVL2/miR-503/PI3K/AKT Axis.

Journal of cardiovascular pharmacology

Cai H,Fan S,Cai L,Zhu L,Zhao Z,Li Y,Yao Y,Huang X,Wang L

Fri Jul 01 00:00:00 UTC 2022

HuB and HuD repress telomerase activity by dissociating HuR from TERC.

Nucleic acids research

Cheng X,Gu X,Xia T,Ma Z,Yang Z,Feng HL,Zhao Y,Ma W,Ju Z,Gorospe M,Yi X,Tang H,Wang W

Thu Mar 18 00:00:00 UTC 2021

HuB and HuD repress telomerase activity by dissociating HuR from TERC.

Nucleic acids research

Cheng X,Gu X,Xia T,Ma Z,Yang Z,Feng HL,Zhao Y,Ma W,Ju Z,Gorospe M,Yi X,Tang H,Wang W

Thu Mar 18 00:00:00 UTC 2021

HuB and HuD repress telomerase activity by dissociating HuR from TERC.

Nucleic acids research

Cheng X,Gu X,Xia T,Ma Z,Yang Z,Feng HL,Zhao Y,Ma W,Ju Z,Gorospe M,Yi X,Tang H,Wang W

Thu Mar 18 00:00:00 UTC 2021

Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma.

American journal of cancer research

Zhao WS,Yan WP,Chen DB,Dai L,Yang YB,Kang XZ,Fu H,Chen P,Deng KJ,Wang XY,Xie XW,Chen HS,Chen KN

Wed Sep 30 00:00:00 UTC 2020

ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles.

EMBO reports

Kato Y,Iwamori T,Ninomiya Y,Kohda T,Miyashita J,Sato M,Saga Y

Thu Dec 05 00:00:00 UTC 2019

New clinicopathological associations and histoprognostic markers in ILAE types of hippocampal sclerosis.

Brain pathology (Zurich, Switzerland)

Calderon-Garcidueñas AL,Mathon B,Lévy P,Bertrand A,Mokhtari K,Samson V,Thuriès V,Lambrecq V,Nguyen VM,Dupont S,Adam C,Baulac M,Clémenceau S,Duyckaerts C,Navarro V,Bielle F

Sat Sep 01 00:00:00 UTC 2018

Tumor cells with neuronal intermediate progenitor features define a subgroup of 1p/19q co-deleted anaplastic gliomas.

Brain pathology (Zurich, Switzerland)

Bielle F,Ducray F,Mokhtari K,Dehais C,Adle-Biassette H,Carpentier C,Chanut A,Polivka M,Poggioli S,Rosenberg S,Giry M,Marie Y,Duyckaerts C,Sanson M,Figarella-Branger D,Idbaih A

Fri Sep 01 00:00:00 UTC 2017

Tumor cells with neuronal intermediate progenitor features define a subgroup of 1p/19q co-deleted anaplastic gliomas.

Brain pathology (Zurich, Switzerland)

Bielle F,Ducray F,Mokhtari K,Dehais C,Adle-Biassette H,Carpentier C,Chanut A,Polivka M,Poggioli S,Rosenberg S,Giry M,Marie Y,Duyckaerts C,Sanson M,Figarella-Branger D,Idbaih A

Fri Sep 01 00:00:00 UTC 2017

ALS Along the Axons - Expression of Coding and Noncoding RNA Differs in Axons of ALS models.

Scientific reports

Rotem N,Magen I,Ionescu A,Gershoni-Emek N,Altman T,Costa CJ,Gradus T,Pasmanik-Chor M,Willis DE,Ben-Dov IZ,Hornstein E,Perlson E

Thu Mar 16 00:00:00 UTC 2017

ALS Along the Axons - Expression of Coding and Noncoding RNA Differs in Axons of ALS models.

Scientific reports

Rotem N,Magen I,Ionescu A,Gershoni-Emek N,Altman T,Costa CJ,Gradus T,Pasmanik-Chor M,Willis DE,Ben-Dov IZ,Hornstein E,Perlson E

Thu Mar 16 00:00:00 UTC 2017

ALS Along the Axons - Expression of Coding and Noncoding RNA Differs in Axons of ALS models.

Scientific reports

Rotem N,Magen I,Ionescu A,Gershoni-Emek N,Altman T,Costa CJ,Gradus T,Pasmanik-Chor M,Willis DE,Ben-Dov IZ,Hornstein E,Perlson E

Thu Mar 16 00:00:00 UTC 2017

ALS Along the Axons - Expression of Coding and Noncoding RNA Differs in Axons of ALS models.

Scientific reports

Rotem N,Magen I,Ionescu A,Gershoni-Emek N,Altman T,Costa CJ,Gradus T,Pasmanik-Chor M,Willis DE,Ben-Dov IZ,Hornstein E,Perlson E

Thu Mar 16 00:00:00 UTC 2017

ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism.

Human molecular genetics

Berto S,Usui N,Konopka G,Fogel BL

Wed Jun 15 00:00:00 UTC 2016

ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism.

Human molecular genetics

Berto S,Usui N,Konopka G,Fogel BL

Wed Jun 15 00:00:00 UTC 2016

miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability.

Cell reports

Parchem RJ,Moore N,Fish JL,Parchem JG,Braga TT,Shenoy A,Oldham MC,Rubenstein JL,Schneider RA,Blelloch R

Tue Aug 04 00:00:00 UTC 2015

miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability.

Cell reports

Parchem RJ,Moore N,Fish JL,Parchem JG,Braga TT,Shenoy A,Oldham MC,Rubenstein JL,Schneider RA,Blelloch R

Tue Aug 04 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B); ELAV like 4; ELAV-like neuronal protein 1; ELAV-like neuronal protein 1 isoform Hel-N2; ELAV-like protein 2; ELAVL 2; ELAVL 4; embryonic lethal, abnormal vision-like 2; Hu antigen B; Hu antigen D; HU-antigen B; HuB; HUD; Nervous system-specific RNA-binding protein Hel-N1; Nervous system-specific RNA-binding protein Mel-N1; RNA binding protein HuB

View more View less

Gene Aliases: Elav2; ELAVL2; HEL-N1; HELN1; HUB; mel-N1

View more View less

UniProt ID: (Human) Q13235, (Mouse) Q60899

View more View less

Entrez Gene ID: (Human) 1993, (Mouse) 15569, (Rat) 286973

View more View less

Function(s)

nucleotide binding mRNA 3'-UTR binding protein binding poly(A) RNA binding nucleic acid binding RNA binding

Process(es)

mRNA splicing, via spliceosome regulation of transcription, DNA-templated

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

ELAVL2 Polyclonal Antibody

ELAVL2 Antibody (14008-1-AP) in IHC (P)

Product Details

14008-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!