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Product Details
S100P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A GST fusion protein ephB1 (Elk receptor) corresponding to amino acid sequence 16-351 of the N terminal, extracellular region, and having a molecular weight of 116 kD
Conjugate
Form
Liquid
Concentration
0.5-2 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Human brain.
Target Information
EPHB1 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. EphB1 and other ephB family members are type 1 membrane spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine rich subdomains in the ecto domain, and the single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. ephB family proteins bind ephrins of the B class, ligands that are also transmembrane spanning proteins capable of transmitting signals. ephB1 is expressed predominantly in developing neural structures in embryos, and in vascular epithelium of kidney, and other tissues. Upon binding to alternatively oligomerized ephrin B1, ephB1 signals regulation of cell attachment and cellcell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EK6; ELK; EPH tyrosine kinase 2; EPH-like kinase 6; Ephrin type-B receptor 1; NET; Neuronally-expressed EPH-related tyrosine kinase; soluble EPHB1 variant 1; Tyrosine-protein kinase receptor EPH-2
Gene Aliases: ELK; EPHB1; EPHT2; HEK6; NET
UniProt ID: (Human) P54762
Entrez Gene ID: (Human) 2047
angiogenesis
immunological synapse formation
axon guidance
peptidyl-tyrosine phosphorylation
optic nerve morphogenesis
central nervous system projection neuron axonogenesis
neurogenesis
establishment of cell polarity
retinal ganglion cell axon guidance
cell-substrate adhesion
regulation of JNK cascade
protein autophosphorylation
ephrin receptor signaling pathway
camera-type eye morphogenesis
detection of temperature stimulus involved in sensory perception of pain
positive regulation of synapse assembly
cell chemotaxis
dendritic spine development
dendritic spine morphogenesis
neural precursor cell proliferation
regulation of ERK1 and ERK2 cascade
regulation of neuron death
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