Proteintech

ELL Polyclonal Antibody

ELL Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ELL Antibody (51044-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human ovary tumor using 51044-1-AP (ELL antibody) at dilution of 1:50 (under 10x lens).

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Product Details

51044-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ELL Fusion Protein Ag0617 (1-500 aa encoded by BC049195)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAALKEDRS YGLSCGRVSD GSKVSVFHVK LTDSALRAFE SYRARQDSVS LRPSIRFQGS QGHISIPQPD CPAEARTFSF YLSNIGRDNP QGSFDCIQQY VSSHGEVHLD CLGSIQDKIT VCATDDSYQK ARQSMAQAEE ETRSRSAIVI KAGGRYLGKK VQFRKPAPGA TDAVPSRKRA TPINLASAIR KSGASAVSGG SGVSQRPFRD RVLHLLALRP YRKAELLLRL QKDGLTQADK DALDGLLQQV ANMSAKDGTC TLQDCMYKDV QKDWPGYSEG DQQLLKRVLV RKLCQPQSTG SLLGDPAASS PPGERGRSAS PPQKRLQPPD FIDPLANKKP RISHFTQRAQ PAVNGKLGVP NGREALLPTP GPPASTDTLS SSTHLPPRLE PPRAHDPLAD VSNDLGHSGR DCEHGEAAAP APTVRLGLPL LTDCAQPSRP HGSPSRSKPK KKSKKHKDKE RAAEDKPRAQ LPDCAPATHA TPGAPADTPG LNGTCSVSSV PT (1-500 aa encoded by BC049195)

Target Information

Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.

Oncogene

Wang H,Bei L,Shah CA,Huang W,Platanias LC,Eklund EA

Tue May 01 00:00:00 UTC 2018

The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.

Oncogene

Wang H,Bei L,Shah CA,Huang W,Platanias LC,Eklund EA

Tue May 01 00:00:00 UTC 2018

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.

Nature communications

Chung CY,Berson A,Kennerdell JR,Sartoris A,Unger T,Porta S,Kim HJ,Smith ER,Shilatifard A,Van Deerlin V,Lee VM,Chen-Plotkin A,Bonini NM

Tue Oct 23 00:00:00 UTC 2018

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.

Nature communications

Chung CY,Berson A,Kennerdell JR,Sartoris A,Unger T,Porta S,Kim HJ,Smith ER,Shilatifard A,Van Deerlin V,Lee VM,Chen-Plotkin A,Bonini NM

Tue Oct 23 00:00:00 UTC 2018

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.

Nature communications

Chung CY,Berson A,Kennerdell JR,Sartoris A,Unger T,Porta S,Kim HJ,Smith ER,Shilatifard A,Van Deerlin V,Lee VM,Chen-Plotkin A,Bonini NM

Tue Oct 23 00:00:00 UTC 2018

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.

Nature communications

Chung CY,Berson A,Kennerdell JR,Sartoris A,Unger T,Porta S,Kim HJ,Smith ER,Shilatifard A,Van Deerlin V,Lee VM,Chen-Plotkin A,Bonini NM

Tue Oct 23 00:00:00 UTC 2018

Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival.

Molecular immunology

Alexander LMM,Watters J,Reusch JA,Maurin M,Nepon-Sixt BS,Vrzalikova K,Alexandrow MG,Murray PG,Wright KL

Wed Nov 01 00:00:00 UTC 2017

Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival.

Molecular immunology

Alexander LMM,Watters J,Reusch JA,Maurin M,Nepon-Sixt BS,Vrzalikova K,Alexandrow MG,Murray PG,Wright KL

Wed Nov 01 00:00:00 UTC 2017

ELL targets c-Myc for proteasomal degradation and suppresses tumour growth.

Nature communications

Chen Y,Zhou C,Ji W,Mei Z,Hu B,Zhang W,Zhang D,Wang J,Liu X,Ouyang G,Zhou J,Xiao W

Thu Mar 24 00:00:00 UTC 2016

ELL targets c-Myc for proteasomal degradation and suppresses tumour growth.

Nature communications

Chen Y,Zhou C,Ji W,Mei Z,Hu B,Zhang W,Zhang D,Wang J,Liu X,Ouyang G,Zhou J,Xiao W

Thu Mar 24 00:00:00 UTC 2016

ELL is an HIF-1alpha partner that regulates and responds to hypoxia response in PC3 cells.

The Prostate

Liu L,Ai J,Xiao W,Liu J,Wang Y,Xin D,He Z,Guo Y,Wang Z

Sat May 15 00:00:00 UTC 2010

ELL is an HIF-1alpha partner that regulates and responds to hypoxia response in PC3 cells.

The Prostate

Liu L,Ai J,Xiao W,Liu J,Wang Y,Xin D,He Z,Guo Y,Wang Z

Sat May 15 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: Eleven-nineteen lysine-rich leukemia protein; ELL gene (11-19 lysine-rich leukemia gene); elongation factor RNA polymerase II; protein phosphatase 1, regulatory subunit 68; RNA polymerase II elongation factor ELL; RNA POLYMERASE II ELONGATION FACTOR ELL (ELEVEN-NINETEEN LYSINE-RICH LEUKEMIA PROTEIN)

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Gene Aliases: C19orf17; ELL; ELL1; MEN; PPP1R68

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UniProt ID: (Human) P55199, (Mouse) O08856

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Entrez Gene ID: (Human) 8178, (Mouse) 13716

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Function(s)

protein binding phosphatase binding

Process(es)

in utero embryonic development transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter negative regulation of phosphatase activity positive regulation of DNA-templated transcription, elongation positive regulation of transcription elongation from RNA polymerase II promoter snRNA transcription from RNA polymerase II promoter snRNA transcription from RNA polymerase III promoter positive regulation of transcription from RNA polymerase III promoter transcription, DNA-templated regulation of transcription, DNA-templated

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ELL Polyclonal Antibody

ELL Antibody (51044-1-AP) in IHC (P)

Product Details

51044-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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