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Product Details
H00326342-M02
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1G10
Immunogen
EMR4P (XP_377506, 21 a.a. approximately 93 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: GSEAKNSGAS CPPCPKYASC HNSTHCTCED GFRARSGRTY FHDSSEKCED INECETGLAK CKYKAYCRNK VGG
Target Information
FIRE is a 689 amino acid protein that maps to human gene EMR4. FIRE is also known as EGF-like module-containing mucin-like hormone receptor-like 4 and is a member of the the G protein-coupled receptor 2 family, LN-TM7 subfamily. The epidermal growth factor-transmembrane seven (EGF-TM7) family are proteins that express EGF-like domains at their extracellular N-terminus coupled to a classical seven-transmembrane (TM7) cassette. FIRE is believed to mediate the cellular interaction between myeloid cells and beta cells. FIRE is a membrane bound, multi-pass protein that is proteolytically cleaved into two subunits, an extracellular alpha subunit and a seven-transmembrane subunit. FIRE contains one GPS (G protein-coupled receptor proteolytic cleavage site) domain and two EGF (epidermal growth factor)-like domains, the second of which mediates the interaction with the putative ligand.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Gene Aliases: EMR4; EMR4P; FIRE; GPR127; PGR16
Entrez Gene ID: (Human) 326342
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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