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Invitrogen
EN1 Polyclonal Antibody
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Product Details
PA5-113648
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human EN1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2884163
Product Specific Information
Immunogen sequence: LNESQIKIWF QNKRAKIKKA TGIKNGLALH LMAQGLYNHS TTTVQDKDES
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 80%
Target Information
EN1 (Engrailed homolog 1) is a transcription factor expressed in embryonic ventral limb ectoderm and is essential for ventral limb patterning. En1 expression in the developing perichordal tube suggests that it may also be involved in vertebrae assembly. Loss of EN1 function in mice results in dorsal transformations of ventral paw structures and in subtle alterations along the proximal/distal limb axis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: engrailed homolog 1; HME1; Homeobox protein en-1; Homeobox protein engrailed-1; hu-En-1
Gene Aliases: EN1
UniProt ID: (Human) Q05925
Entrez Gene ID: (Human) 2019
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
adult locomotory behavior
anatomical structure morphogenesis
dorsal/ventral pattern formation
proximal/distal pattern formation
cerebellum development
midbrain development
midbrain-hindbrain boundary development
embryonic forelimb morphogenesis
social behavior
multicellular organism growth
drinking behavior
pigmentation
negative regulation of neuron apoptotic process
positive regulation of transcription from RNA polymerase II promoter
neuron development
motor learning
dopaminergic neuron differentiation
embryonic brain development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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