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Abnova
ENPP1 Polyclonal Antibody, MaxPab™
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Product Details
H00005167-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ENPP1 (NP_006199.1, 1 a.a. approximately 873 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDVGEEPLEK AARARTAKDP NTYKVLSLVL SVCVLTTILG CIFGLKPSCA KEVKSCKGRC FERTFGNCRC DAACVELGNC CLDYQETCIE PEHIWTCNKF RCGEKRLTRS LCACSDDCKD KGDCCINYSS VCQGEKSWVE EPCESINEPQ CPAGFETPPT LLFSLDGFRA EYLHTWGGLL PVISKLKKCG TYTKNMRPVY PTKTFPNHYS IVTGLYPESH GIIDNKMYDP KMNASFSLKS KEKFNPEWYK GEPIWVTAKY QGLKSGTFFW PGSDVEINGI FPDIYKMYNG SVPFEERILA VLQWLQLPKD ERPHFYTLYL EEPDSSGHSY GPVSSEVIKA LQRVDGMVGM LMDGLKELNL HRCLNLILIS DHGMEQGSCK KYIYLNKYLG DVKNIKVIYG PAARLRPSDV PDKYYSFNYE GIARNLSCRE PNQHFKPYLK HFLPKRLHFA KSDRIEPLTF YLDPQWQLAL NPSERKYCGS GFHGSDNVFS NMQALFVGYG PGFKHGIEAD TFENIEVYNL MCDLLNLTPA PNNGTHGSLN HLLKNPVYTP KHPKEVHPLV QCPFTRNPRD NLGCSCNPSI LPIEDFQTQF NLTVAEEKII KHETLPYGRP RVLQKENTIC LLSQHQFMSG YSQDILMPLW TSYTVDRNDS FSTEDFSNCL YQDFRIPLSP VHKCSFYKNN TKVSYGFLSP PQLNKNSSGI YSEALLTTNI VPMYQSFQVI WRYFHDTLLR KYAEERNGVN VVSGPVFDFD YDGRCDSLEN LRQKRRVIRN QEILIPTHFF IVLTSCKDTS QTPLHCENLD TLAFILPHRT DNSESCVHGK HDSSWVEELL MLHRARITDV EHITGLSFYQ QRKEPVSDIL KLKTHLPTFS QED
Target Information
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alkaline phosphodiesterase 1; Alkaline phosphodiesterase I; E-NPP 1; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; HGNC:3356; Ly-41 antigen; Membrane component chromosome 6 surface marker 1; membrane component, chromosome 6, surface marker 1; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; OTTHUMP00000043194; Phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein 1; Plasma-cell membrane glycoprotein PC-1
Gene Aliases: ARHR2; COLED; ENPP1; M6S1; NPP1; NPPS; PC-1; PC1; PCA1; PDNP1
UniProt ID: (Human) P22413
Entrez Gene ID: (Human) 5167
nucleic acid binding
phosphodiesterase I activity
nucleotide diphosphatase activity
scavenger receptor activity
insulin receptor binding
calcium ion binding
protein binding
ATP binding
zinc ion binding
polysaccharide binding
NADH pyrophosphatase activity
protein homodimerization activity
nucleoside-triphosphate diphosphatase activity
3'-phosphoadenosine 5'-phosphosulfate binding
generation of precursor metabolites and energy
riboflavin metabolic process
phosphate-containing compound metabolic process
receptor-mediated endocytosis
immune response
nucleoside triphosphate catabolic process
negative regulation of cell growth
regulation of bone mineralization
inorganic diphosphate transport
cellular phosphate ion homeostasis
sequestering of triglyceride
biomineral tissue development
negative regulation of protein autophosphorylation
cellular response to insulin stimulus
negative regulation of fat cell differentiation
negative regulation of glycogen biosynthetic process
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
3'-phosphoadenosine 5'-phosphosulfate metabolic process
nucleic acid phosphodiester bond hydrolysis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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