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Invitrogen
ENPP2 Polyclonal Antibody
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Product Details
PA5-85221
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human Autotaxin. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2792364
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (93%), Rat (94%), Chicken (81%), Bovine (93%).
Positive Control: human cerebrospinal fluid, mouse brain, rat brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Autotaxin; autotaxin-t; AutotaxinATX; E-NPP 2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Extracellular lysophospholipase D; FLJ26803; LysoPLD; phosphodiesterase I/nucleotide pyrophosphatase 2; plasma lysophospholipase D
Gene Aliases: ATX; ATX-X; AUTOTAXIN; ENPP2; LysoPLD; NPP2; Npps2; PD-IALPHA; PDNP2
UniProt ID: (Human) Q13822, (Mouse) Q9R1E6
Entrez Gene ID: (Human) 5168, (Mouse) 18606
nucleic acid binding
phosphodiesterase I activity
nucleotide diphosphatase activity
lysophospholipase activity
scavenger receptor activity
calcium ion binding
transcription factor binding
zinc ion binding
hydrolase activity
polysaccharide binding
alkylglycerophosphoethanolamine phosphodiesterase activity
catalytic activity
metal ion binding
negative regulation of cell-matrix adhesion
lipid metabolic process
chemotaxis
immune response
metabolic process
positive regulation of cell proliferation
phospholipid catabolic process
positive regulation of epithelial cell migration
lipid catabolic process
regulation of cell migration
phosphatidylcholine catabolic process
regulation of angiogenesis
positive regulation of oligodendrocyte differentiation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of focal adhesion assembly
cell chemotaxis
nucleic acid phosphodiester bond hydrolysis
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of lamellipodium morphogenesis
phosphate-containing compound metabolic process
receptor-mediated endocytosis
movement of cell or subcellular component
G-protein coupled receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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