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Immunogen sequence: IHKQEVLPPG LKYGIVLDAG SSRTTVYVYQ WPAEKENNTG VVSQTFKCSV KGSGISSYGN NPQDVPRAFE ECMQKVKGQV PSHLHGSTPI HLGATAGMRL LRLQNETAAN EVLESIQSYF KSQPFDFRGA QIISGQEEGV YGWITANYLM GNFLEKNLWH MWVHPHGVET TGALDLGGAS TQISFVAGEK MDLNTSDIMQ VSLYGYVYTL YTHSFQCYGR NEAEKKFLAM LLQNSPTKNH LTNPCYPRDY SISFTMGHVF DSLCTVDQRP ESYNPNDVIT FEGTGDPSLC KEKVASIFDF KACHDQETCS FDGVYQPKIK GP; Positive Samples: Mouse lung; Cellular Location: Membrane, Multi-pass membrane protein
T-cadherin was initially identified as cadherin-type cell adhesion molecule expressed in various neuronal populations in a temporally and spatially restricted pattern during axon growth. T-cadherin is an atypical member of the cadherin family because it does not possess the typical transmembrane and cytoplasmic domains but is instead anchored to the plasma membrane by glycosylphosphatidylinositol (GPI) linkage. T-cadherin may play a role in malignant tumor development as loss of the chromosome locus containing the T-cadherin gene correlates with the development of a variety of cancers. Recently it has been shown that T-cadherin can act as a receptor for hexameric and high-molecular weight forms of adiponectin, suggesting that T-cadherin may also play a role in metabolic regulation.
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Protein Aliases: CD39 antigen-like 3; CD39-like 3; Ecto-ATP diphosphohydrolase 3; Ecto-ATPDase 3; Ectonucleoside triphosphate diphosphohydrolase 3; NTPDase 3
Gene Aliases: Cd39l3; Entpd3; HB6; NTPDase-3
UniProt ID: (Mouse) Q8BFW6
Entrez Gene ID: (Mouse) 215446
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