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Alomone Labs, LTD
ENaC gamma (SCNN1G) (extracellular) Polyclonal Antibody
FIGURE: 1 / 1
ENaC gamma (SCNN1G) (extracellular) Antibody (ASC-011-200UL) in WB
Western blot analysisof rat lung lysate: - 1. Anti-ENaC gamma (SCNN1G) (extracellular) Antibody (#ASC-011), (1:200). 2. Anti-ENaC gamma (SCNN1G) (extracellular) Antibody , preincubated with ENaC gamma/SCNN1G (extracellular) Blocking Peptide (#BLP-SC011).
Product Details
ASC-011-200UL
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)YGVKESRKRREAGS, corresponding to amino acid residues 129-142 of rat ENaC gamma , Extracellular
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Epithelial sodium channels are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel's syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: amiloride sensitive sodium channel gamma1 subunit; Amiloride-sensitive sodium channel subunit gamma; epithelial Na(+) channel subunit gamma; epithelial sodium channel gamma subunit; Epithelial sodium channel subunit gamma; Gamma ENaC; Gamma NaCH; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; PHA 1; SCNEG; SCNN 1G; Sodium channel nonvoltage-gated 1 gamma (epithelial); Sodium channel, nonvoltage-gated 1, gamma (epithelial); sodium channel, nonvoltage-gated, type I, gamma
Gene Aliases: ENaC; RCNaCh2; Scnn1g
UniProt ID: (Rat) P37091
Entrez Gene ID: (Rat) 24768
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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