Product References
Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
Nature communications
Rožmanić C,Lisnić B,Pribanić Matešić M,Mihalić A,Hiršl L,Park E,Lesac Brizić A,Indenbirken D,Viduka I,Šantić M,Adler B,Yokoyama WM,Krmpotić A,Juranić Lisnić V,Jonjić S,Brizić I
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Thu Oct 12 00:00:00 UTC 2023
KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.
Nature communications
Zhang B,Zhao C,Shen W,Li W,Zheng Y,Kong X,Wang J,Wu X,Zeng T,Liu Y,Zhou Y
14-4875-82 was used in Immunohistochemistry to reveal that Wnt signaling genes in developing Kdm2bΔCxxC hippocampi are de-repressed due to reduced enrichment of repressive histone marks by polycomb repressive complexes.
Sat Oct 14 00:00:00 UTC 2023
D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase.
Cell reports
Liu Y,Wang M,Guo Y,Wang L,Guo W
14-4875-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot to study the exact metabolic program governs the balance between quiescent and activated RGLs.
Tue Feb 28 00:00:00 UTC 2023
CyTOF protocol for immune monitoring of solid tumors from mouse models.
STAR protocols
Shin SM,Hernandez A,Coyne E,Munjal K,Gross NE,Charmsaz S,Yuan X,Yang H,Ho WJ
14-4875-82 was used in Flow Cytometry to describe mass cytometry (cytometry by time-of-flight) procedures to facilitate high-parameter profiling of low-volume survival blood samples and end-of-study tumor samples.
Fri Mar 17 00:00:00 UTC 2023
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Nature communications
Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Fri Mar 24 00:00:00 UTC 2023
PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity.
Cancer discovery
Wiede F,Lu KH,Du X,Zeissig MN,Xu R,Goh PK,Xirouchaki CE,Hogarth SJ,Greatorex S,Sek K,Daly RJ,Beavis PA,Darcy PK,Tonks NK,Tiganis T
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Tue Mar 01 00:00:00 UTC 2022
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3.
Nature immunology
Grebinoski S,Zhang Q,Cillo AR,Manne S,Xiao H,Brunazzi EA,Tabib T,Cardello C,Lian CG,Murphy GF,Lafyatis R,Wherry EJ,Das J,Workman CJ,Vignali DAA
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Wed Jun 01 00:00:00 UTC 2022
Dentate gyrus morphogenesis is regulated by β-catenin function in hem-derived fimbrial glia.
Development (Cambridge, England)
Parichha A,Datta D,Suresh V,Chatterjee M,Holtzman MJ,Tole S
14-4875-82 was used in Immunohistochemistry to highlight a primary requirement for β-catenin for the organization of the fimbrial scaffold and a secondary role for this factor in dentate gyrus morphogenesis.
Tue Nov 01 00:00:00 UTC 2022
A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Park JY,Liu F,Olesen KM,Hou S,Peng JC,Infield J,Levesque AC,Wang YD,Jin H,Fan Y,Connelly PJ,Pruett-Miller SM,Hu MG,Hinds PW,Han YG
14-4875-82 was used in Immunohistochemistry-immunofluorescence to indicate that CDK6 is conserved to promote oRG expansion, that oRGs are necessary for neocortical folding, and that defects in oRG expansion may cause primary microcephaly.
Tue Sep 20 00:00:00 UTC 2022
Phosphatidylinositol transfer protein/planar cell polarity axis regulates neocortical morphogenesis by supporting interkinetic nuclear migration.
Cell reports
Xie Z,Bankaitis VA
14-4875-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that a phosphatidylinositol transfer protein (PITP)/non-canonical Wnt planar cell polarity (ncPCP) signaling axis promotes tangential expansion of developing neocortex.
Tue May 31 00:00:00 UTC 2022
A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors.
Cell discovery
Wang J,Wang A,Tian K,Hua X,Zhang B,Zheng Y,Kong X,Li W,Xu L,Wang J,Li Z,Liu Y,Zhou Y
14-4875-82 was used in Immunohistochemistry to identify neCtnnb1, an evolutionarily conserved cis-regulatory element with typical enhancer features in developing Ncx.
Tue Aug 02 00:00:00 UTC 2022
Unified rhombic lip origins of group 3 and group 4 medulloblastoma.
Nature
Smith KS,Bihannic L,Gudenas BL,Haldipur P,Tao R,Gao Q,Li Y,Aldinger KA,Iskusnykh IY,Chizhikov VV,Scoggins M,Zhang S,Edwards A,Deng M,Glass IA,Overman LM,Millman J,Sjoboen AH,Hadley J,Golser J,Mankad K,Sheppard H,Onar-Thomas A,Gajjar A,Robinson GW,Hovestadt V,Orr BA,Patay Z,Millen KJ,Northcott PA
14-4875-82 was used in Immunohistochemistry-immunofluorescence to find that the molecular and phenotypic features of clinically challenging medulloblastoma subgroups to their unified beginnings in the rhombic lip in the early stages of human development.
Thu Sep 01 00:00:00 UTC 2022
miR-137 and miR-122, two outer subventricular zone non-coding RNAs, regulate basal progenitor expansion and neuronal differentiation.
Cell reports
Tomasello U,Klingler E,Niquille M,Mule N,Santinha AJ,de Vevey L,Prados J,Platt RJ,Borrell V,Jabaudon D,Dayer A
14-4875-82 was used in Immunohistochemistry to support a cell-type-specific role of miRNA-mediated gene expression in cortical expansion.
Tue Feb 15 00:00:00 UTC 2022
Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection.
Immunity
Xu W,Snell LM,Guo M,Boukhaled G,Macleod BL,Li M,Tullius MV,Guidos CJ,Tsao MS,Divangahi M,Horwitz MA,Liu J,Brooks DG
14-4875-82 was used in Miscellaneous to examine how chronic viral infections alter the pulmonary microenvironment to foster coinfection and worsen disease severity.
Tue Mar 09 00:00:00 UTC 2021
Visualization of individual cell division history in complex tissues using iCOUNT.
Cell stem cell
Denoth-Lippuner A,Jaeger BN,Liang T,Royall LN,Chie SE,Buthey K,Machado D,Korobeynyk VI,Kruse M,Munz CM,Gerbaulet A,Simons BD,Jessberger S
14-4875-82 was used in Immunohistochemistry to characterize the molecular consequences of repeated cell divisions of stem cells that allows an analysis of the cellular principles underlying tissue formation, homeostasis, and repair by inducible cell division counter (iCOUNT).
Thu Nov 04 00:00:00 UTC 2021
BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex.
Genes & development
Braun SMG,Petrova R,Tang J,Krokhotin A,Miller EL,Tang Y,Panagiotakos G,Crabtree GR
14-4875-82 was used in Immunohistochemistry to investigate the role of the BAF subunit in neuronal cell cycle exit and differentiation in intellectual disabilities.
Mon Mar 01 00:00:00 UTC 2021
BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex.
Genes & development
Braun SMG,Petrova R,Tang J,Krokhotin A,Miller EL,Tang Y,Panagiotakos G,Crabtree GR
14-4875-82 was used in Immunohistochemistry to investigate the role of the BAF subunit in neuronal cell cycle exit and differentiation in intellectual disabilities.
Mon Mar 01 00:00:00 UTC 2021
Interferon Lambda Regulates Cellular and Humoral Immunity in Pristane-Induced Lupus.
International journal of molecular sciences
Aschman T,Schaffer S,Biniaris Georgallis SI,Triantafyllopoulou A,Staeheli P,Voll RE
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Fri Oct 29 00:00:00 UTC 2021
B cells promote CD8 T cell primary and memory responses to subunit vaccines.
Cell reports
Klarquist J,Cross EW,Thompson SB,Willett B,Aldridge DL,Caffrey-Carr AK,Xu Z,Hunter CA,Getahun A,Kedl RM
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Tue Aug 24 00:00:00 UTC 2021
Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.
PLoS genetics
Rashidieh B,Shohayeb B,Bain AL,Fortuna PRJ,Sinha D,Burgess A,Mills R,Adams RC,Lopez JA,Blumbergs P,Finnie J,Kalimutho M,Piper M,Hudson JE,Ng DCH,Khanna KK
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Immunocytochemistry
Fri Oct 01 00:00:00 UTC 2021
Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.
PLoS genetics
Rashidieh B,Shohayeb B,Bain AL,Fortuna PRJ,Sinha D,Burgess A,Mills R,Adams RC,Lopez JA,Blumbergs P,Finnie J,Kalimutho M,Piper M,Hudson JE,Ng DCH,Khanna KK
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Immunocytochemistry
Fri Oct 01 00:00:00 UTC 2021
LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis.
Nature communications
Hu HB,Song ZQ,Song GP,Li S,Tu HQ,Wu M,Zhang YC,Yuan JF,Li TT,Li PY,Xu YL,Shen XL,Han QY,Li AL,Zhou T,Chun J,Zhang XM,Li HY
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Immunohistochemistry
Thu Jan 28 00:00:00 UTC 2021
Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis.
Scientific reports
Khuu MA,Nallamothu T,Castro-Rivera CI,Arias-Cavieres A,Szujewski CC,Garcia Iii AJ
14-4875 was used in Flow cytometry/Cell sorting to demonstrate that IH creates a pro-oxidant condition that reduces the Tbr2+ neural progenitor pool early in the process, while also suppressing terminal differentiation of adult born neurons during late adult neurogenesis.
Tue Mar 16 00:00:00 UTC 2021
Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis.
Scientific reports
Khuu MA,Nallamothu T,Castro-Rivera CI,Arias-Cavieres A,Szujewski CC,Garcia Iii AJ
14-4875 was used in Flow cytometry/Cell sorting to demonstrate that IH creates a pro-oxidant condition that reduces the Tbr2+ neural progenitor pool early in the process, while also suppressing terminal differentiation of adult born neurons during late adult neurogenesis.
Tue Mar 16 00:00:00 UTC 2021
CD8+ T cells specific for cryptic apoptosis-associated epitopes exacerbate experimental autoimmune encephalomyelitis.
Cell death & disease
Feizi N,Focaccetti C,Pacella I,Tucci G,Rossi A,Costanza M,Pedotti R,Sidney J,Sette A,La Rocca C,Procaccini C,Matarese G,Barnaba V,Piconese S
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Fri Oct 29 00:00:00 UTC 2021
Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.
Science advances
Shariq M,Sahasrabuddhe V,Krishna S,Radha S,Bellampalli R,Dwivedi A,Cheramangalam R,Reizis B,Hébert J,Ghosh HS
14-4875 was used in Western Blotting to provide evidence for a latent inflammatory potential of adult hippocampal neural progenitors and identify Tcf4 as a critical regulator that facilitates adult neurogenesis via proactive suppression of this detrimental potential.
Sat May 01 00:00:00 UTC 2021
Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.
Cancer cell
Hutton C,Heider F,Blanco-Gomez A,Banyard A,Kononov A,Zhang X,Karim S,Paulus-Hock V,Watt D,Steele N,Kemp S,Hogg EKJ,Kelly J,Jackstadt RF,Lopes F,Menotti M,Chisholm L,Lamarca A,Valle J,Sansom OJ,Springer C,Malliri A,Marais R,Pasca di Magliano M,Zelenay S,Morton JP,Jørgensen C
14-4875-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot to reveal two functionally distinct pancreatic fibroblast lineages and highlight the importance of mesenchymal and immune cell interactions in restricting tumor growth.
Mon Sep 13 00:00:00 UTC 2021
Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation.
JCI insight
Hope HC,Brownlie RJ,Fife CM,Steele L,Lorger M,Salmond RJ
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Mon May 10 00:00:00 UTC 2021
Increase of α-dicarbonyls in liver and receptor for advanced glycation end products on immune cells are linked to nonalcoholic fatty liver disease and liver cancer.
Oncoimmunology
Petriv N,Neubert L,Vatashchuk M,Timrott K,Suo H,Hochnadel I,Huber R,Petzold C,Hrushchenko A,Yatsenko AS,Shcherbata HR,Wedemeyer H,Lichtinghagen R,Falfushynska H,Lushchak V,Manns MP,Bantel H,Semchyshyn H,Yevsa T
14-4875-82 was used in Immunohistochemistry to investigate if α-dicarbonyl compounds (α-dC), are highly reactive and tightly associated with overweight-induced metabolic disorders, and studied their potential role in NAFLD and progression toward HCC using murine models.
Mon Feb 08 00:00:00 UTC 2021
An epigenetic circuit controls neurogenic programs during neocortex development.
Development (Cambridge, England)
Wang A,Wang J,Tian K,Huo D,Ye H,Li S,Zhao C,Zhang B,Zheng Y,Xu L,Hua X,Wang K,Wu QF,Wu X,Zeng T,Liu Y,Zhou Y
14-4875-82 was used in Immunohistochemistry to characterize an epigenetic circuit that precisely controls neurogenic programs, particularly properties of IPs, during neocortical development.
Mon Nov 15 00:00:00 UTC 2021
Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy.
Cancer cell
Wang Y,Liu S,Yang Z,Algazi AP,Lomeli SH,Wang Y,Othus M,Hong A,Wang X,Randolph CE,Jones AM,Bosenberg MW,Byrum SD,Tackett AJ,Lopez H,Yates C,Solit DB,Ribas A,Piva M,Moriceau G,Lo RS
14-4875-82 was used in Flow Cytometry to demonstrate that anti-PD-1/L1 lead-in preceding MAPKi combination optimizes response durability by promoting pro-inflammatory polarization of macrophages and clonal expansion of interferon-γhi, and CD8+ cytotoxic and proliferative T cells.
Mon Oct 11 00:00:00 UTC 2021
Sequential perturbations to mouse corticogenesis following in utero maternal immune activation.
eLife
Canales CP,Estes ML,Cichewicz K,Angara K,Aboubechara JP,Cameron S,Prendergast K,Su-Feher L,Zdilar I,Kreun EJ,Connolly EC,Seo JM,Goon JB,Farrelly K,Stradleigh TW,van der List D,Haapanen L,Van de Water J,Vogt D,McAllister AK,Nord AS
14-4875-82 was used in Immunohistochemistry-immunofluorescence to reveal a sequence of perturbations to corticogenesis driven by mid-gestational maternal immune activation.
Fri Mar 05 00:00:00 UTC 2021
Centrosome anchoring regulates progenitor properties and cortical formation.
Nature
Shao W,Yang J,He M,Yu XY,Lee CH,Yang Z,Joyner AL,Anderson KV,Zhang J,Tsou MB,Shi H,Shi SH
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Immunocytochemistry
Wed Apr 01 00:00:00 UTC 2020
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy.
The Journal of experimental medicine
Oda SK,Anderson KG,Ravikumar P,Bonson P,Garcia NM,Jenkins CM,Zhuang S,Daman AW,Chiu EY,Bates BM,Greenberg PD
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Mon Dec 07 00:00:00 UTC 2020
Oxidative stress regulates progenitor behavior and cortical neurogenesis.
Development (Cambridge, England)
Chui A,Zhang Q,Dai Q,Shi SH
14-4875 was used in Immunohistochemistry to suggest that oxidative stress actively regulates RGP behavior to ensure proper neurogenesis in the mammalian cortex.
Wed Mar 11 00:00:00 UTC 2020
The Spindle-Associated Microcephaly Protein, WDR62, Is Required for Neurogenesis and Development of the Hippocampus.
Frontiers in cell and developmental biology
Shohayeb B,Ho UY,Hassan H,Piper M,Ng DCH
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Immunohistochemistry
Tue Oct 13 00:00:00 UTC 2020
Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.
Human molecular genetics
Gilet JG,Ivanova EL,Trofimova D,Rudolf G,Meziane H,Broix L,Drouot N,Courraud J,Skory V,Voulleminot P,Osipenko M,Bahi-Buisson N,Yalcin B,Birling MC,Hinckelmann MV,Kwok BH,Allingham JS,Chelly J
14-4875 was used in Immunohistochemistry to investigate RosaCre-, NestinCre- and NexCre-driven expression of the mutation to dissect the pathophysiological mechanisms underlying neurodevelopmental cortical abnormalities.
Fri Mar 27 00:00:00 UTC 2020
Developmental exposure to diesel exhaust upregulates transcription factor expression, decreases hippocampal neurogenesis, and alters cortical lamina organization: relevance to neurodevelopmental disorders.
Journal of neurodevelopmental disorders
Cole TB,Chang YC,Dao K,Daza R,Hevner R,Costa LG
14-4875-82 was used in Immunohistochemistry to assess the expression of several transcription factors relevant for CNS development after C57BL/6 J mice were exposed to environmentally relevant levels (250+/-50 µg/m3) of diesel exhaust (DE) or filtered air (FA) during development (E0 to PND21).
Wed Dec 16 00:00:00 UTC 2020
Developmental exposure to diesel exhaust upregulates transcription factor expression, decreases hippocampal neurogenesis, and alters cortical lamina organization: relevance to neurodevelopmental disorders.
Journal of neurodevelopmental disorders
Cole TB,Chang YC,Dao K,Daza R,Hevner R,Costa LG
14-4875-82 was used in Immunohistochemistry to assess the expression of several transcription factors relevant for CNS development after C57BL/6 J mice were exposed to environmentally relevant levels (250+/-50 µg/m3) of diesel exhaust (DE) or filtered air (FA) during development (E0 to PND21).
Wed Dec 16 00:00:00 UTC 2020
Loss of the neurodevelopmental disease-associated gene miR-146a impairs neural progenitor differentiation and causes learning and memory deficits.
Molecular autism
Fregeac J,Moriceau S,Poli A,Nguyen LS,Oury F,Colleaux L
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Immunocytochemistry
Mon Mar 30 00:00:00 UTC 2020
Loss of the neurodevelopmental disease-associated gene miR-146a impairs neural progenitor differentiation and causes learning and memory deficits.
Molecular autism
Fregeac J,Moriceau S,Poli A,Nguyen LS,Oury F,Colleaux L
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Immunocytochemistry
Mon Mar 30 00:00:00 UTC 2020
Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants.
Cell reports. Medicine
Marinaik CB,Kingstad-Bakke B,Lee W,Hatta M,Sonsalla M,Larsen A,Neldner B,Gasper DJ,Kedl RM,Kawaoka Y,Suresh M
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Tue Sep 22 00:00:00 UTC 2020
Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches.
eLife
Nelson BR,Hodge RD,Daza RA,Tripathi PP,Arnold SJ,Millen KJ,Hevner RF
14-4875 was used in Immunohistochemistry to show that intermediate progenitors interact with mitotic and migrating NSCs throughout all stages of DG development.
Fri Apr 03 00:00:00 UTC 2020
Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches.
eLife
Nelson BR,Hodge RD,Daza RA,Tripathi PP,Arnold SJ,Millen KJ,Hevner RF
14-4875 was used in Immunohistochemistry to show that intermediate progenitors interact with mitotic and migrating NSCs throughout all stages of DG development.
Fri Apr 03 00:00:00 UTC 2020
Reelin Mediates Hippocampal Cajal-Retzius Cell Positioning and Infrapyramidal Blade Morphogenesis.
Journal of developmental biology
Ha S,Tripathi PP,Daza RA,Hevner RF,Beier DR
14-4875 was used in Immunohistochemistry to report several developmental anomalies in the RelnCTRdel dentate gyrus.
Fri Sep 18 00:00:00 UTC 2020
Reelin Mediates Hippocampal Cajal-Retzius Cell Positioning and Infrapyramidal Blade Morphogenesis.
Journal of developmental biology
Ha S,Tripathi PP,Daza RA,Hevner RF,Beier DR
14-4875 was used in Immunohistochemistry to report several developmental anomalies in the RelnCTRdel dentate gyrus.
Fri Sep 18 00:00:00 UTC 2020
Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex.
Neuron
Xing L,Kalebic N,Namba T,Vaid S,Wimberger P,Huttner WB
14-4875-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot to show that 5-HT emerges as an important extrinsic pro-proliferative signal for BPs, which may have contributed to evolutionary Ncx expansion.
Wed Dec 23 00:00:00 UTC 2020
TNIK signaling imprints CD8+ T cell memory formation early after priming.
Nature communications
Jaeger-Ruckstuhl CA,Hinterbrandner M,Höpner S,Correnti CE,Lüthi U,Friedli O,Freigang S,Al Sayed MF,Bührer ED,Amrein MA,Schürch CM,Radpour R,Riether C,Ochsenbein AF
14-4875-82 was used in Flow Cytometry to analyse the role of the TRAF2-/NCK-interacting kinase (TNIK), a signaling molecule downstream of the tumor necrosis factor superfamily receptors such as CD27, in the regulation of CD8+ T cell fate during acute infection with lymphocytic choriomeningitis virus.
Thu Apr 02 00:00:00 UTC 2020
Single-cell transcriptome analysis reveals TOX as a promoting factor for T cell exhaustion and a predictor for anti-PD-1 responses in human cancer.
Genome medicine
Kim K,Park S,Park SY,Kim G,Park SM,Cho JW,Kim DH,Park YM,Koh YW,Kim HR,Ha SJ,Lee I
14-4875 was used in Flow cytometry/Cell sorting to identify the regulatory factors involved in tumor-infiltrating CD8+ T cell exhaustion by analyzing the scRNA-seq data.
Fri Feb 28 00:00:00 UTC 2020
Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.
Cell reports
Journiac N,Gilabert-Juan J,Cipriani S,Benit P,Liu X,Jacquier S,Faivre V,Delahaye-Duriez A,Csaba Z,Hourcade T,Melinte E,Lebon S,Violle-Poirsier C,Oury JF,Adle-Biassette H,Wang ZQ,Mani S,Rustin P,Gressens P,Nardelli J
14-4875-82 was used in Immunohistochemistry to report the description of a MCPH-gene implication in the interplay between bioenergetic pathways and neocortical growth, thus pointing to alterations of cellular metabolic pathways, in particular glutaminolysis, as a possible cause of microcephalic pathogenesis.
Tue Apr 14 00:00:00 UTC 2020
Ephrin-B2 paces neuronal production in the developing neocortex.
BMC developmental biology
Kischel A,Audouard C,Fawal MA,Davy A
14-4875 was used in Immunohistochemistry-immunofluorescence to investigate if ephrin-B2, a member of the Eph:ephrin cell-to-cell communication pathway, sets the neurogenic tempo in the neocortex.
Wed May 13 00:00:00 UTC 2020
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Cell
Ponzetta A,Carriero R,Carnevale S,Barbagallo M,Molgora M,Perucchini C,Magrini E,Gianni F,Kunderfranco P,Polentarutti N,Pasqualini F,Di Marco S,Supino D,Peano C,Cananzi F,Colombo P,Pilotti S,Alomar SY,Bonavita E,Galdiero MR,Garlanda C,Mantovani A,Jaillon S
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Thu Jul 11 00:00:00 UTC 2019
Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development.
Neuron
Nakagawa N,Plestant C,Yabuno-Nakagawa K,Li J,Lee J,Huang CW,Lee A,Krupa O,Adhikari A,Thompson S,Rhynes T,Arevalo V,Stein JL,Molnár Z,Badache A,Anton ES
14-4875-82 was used in Immunohistochemistry to show that mediator of cell motility 1 (Memo1) is a critical determinant of radial glial tiling during neocortical development.
Wed Sep 04 00:00:00 UTC 2019
p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects.
Human molecular genetics
Little JN,Dwyer ND
14-4875-82 was used in Immunohistochemistry to elucidate both NSC apoptosis and abscission mechanisms that could underlie human microcephaly or other brain malformations.
Fri Feb 01 00:00:00 UTC 2019
PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice.
eLife
Roy A,Murphy RM,Deng M,MacDonald JW,Bammler TK,Aldinger KA,Glass IA,Millen KJ
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Immunofluorescence
Thu May 16 00:00:00 UTC 2019
EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming.
Nature communications
Istaces N,Splittgerber M,Lima Silva V,Nguyen M,Thomas S,Le A,Achouri Y,Calonne E,Defrance M,Fuks F,Goriely S,Azouz A
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Wed Jul 24 00:00:00 UTC 2019
Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb.
eLife
Sánchez-Guardado L,Lois C
14-4875 was used in Immunocytochemistry to investigate whether lineage plays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfactory bulb.
Tue Aug 27 00:00:00 UTC 2019
Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome.
eLife
Panagiotakos G,Haveles C,Arjun A,Petrova R,Rana A,Portmann T,Paşca SP,Palmer TD,Dolmetsch RE
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Immunofluorescence
Mon Dec 23 00:00:00 UTC 2019
Early dorsomedial tissue interactions regulate gyrification of distal neocortex.
Nature communications
Chizhikov VV,Iskusnykh IY,Steshina EY,Fattakhov N,Lindgren AG,Shetty AS,Roy A,Tole S,Millen KJ
14-4875-82 was used in Immunohistochemistry to uncover early mesenchymal-neuroepithelial interactions that have long-range effects on neocortical gyrification and shows that lissencephaly in mice is actively maintained via redundant genetic regulation of dorsal midline development and signaling.
Fri Nov 15 00:00:00 UTC 2019
Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.
Cell
Silva CG,Peyre E,Adhikari MH,Tielens S,Tanco S,Van Damme P,Magno L,Krusy N,Agirman G,Magiera MM,Kessaris N,Malgrange B,Andrieux A,Janke C,Nguyen L
14-4875 was used in Flow cytometry/Cell sorting to demonstrate that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons.
Thu Feb 22 00:00:00 UTC 2018
The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
The Journal of clinical investigation
Wang B,Joo JH,Mount R,Teubner BJW,Krenzer A,Ward AL,Ichhaporia VP,Adams EJ,Khoriaty R,Peters ST,Pruett-Miller SM,Zakharenko SS,Ginsburg D,Kundu M
14-4875 was used in Immunohistochemistry to demonstrate that postmitotic neurons are exquisitely sensitive to loss of SEC24C.
Wed Aug 01 00:00:00 UTC 2018
B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation.
The Journal of experimental medicine
Singh MD,Ni M,Sullivan JM,Hamerman JA,Campbell DJ
14-4875 was used in Flow cytometry/Cell sorting to show induction of BCAP serves as a positive feedback circuit to enhance PI3K signaling in activated CD8+ T cells, thereby acting as a molecular checkpoint regulating effector and memory T cell development.
Mon Sep 03 00:00:00 UTC 2018
PPAR-Induced Fatty Acid Oxidation in T Cells Increases the Number of Tumor-Reactive CD8+ T Cells and Facilitates Anti-PD-1 Therapy.
Cancer immunology research
Chowdhury PS,Chamoto K,Kumar A,Honjo T
14-4875 was used in Flow cytometry/Cell sorting to study the molecular mechanism of the synergistic effects of bezafibrate on the tumouricidal effects of PD-1 blockade.
Thu Nov 01 00:00:00 UTC 2018
mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.
Open life sciences
Wang H,Xiao Y,Su L,Cui N,Liu D
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Mon Jan 01 00:00:00 UTC 2018
Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection.
Nature communications
Rolot M,Dougall AM,Chetty A,Javaux J,Chen T,Xiao X,Machiels B,Selkirk ME,Maizels RM,Hokke C,Denis O,Brombacher F,Vanderplasschen A,Gillet L,Horsnell WGC,Dewals BG
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Tue Oct 30 00:00:00 UTC 2018
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
Nature communications
Zhu L,Xie X,Zhang L,Wang H,Jie Z,Zhou X,Shi J,Zhao S,Zhang B,Cheng X,Sun SC
14-4875 was used in Flow cytometry/Cell sorting to study the mechanism of IL-15 function in autophagy and natural killer cell survival.
Wed Jul 18 00:00:00 UTC 2018
Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex.
Cell
Vitali I,Fièvre S,Telley L,Oberst P,Bariselli S,Frangeul L,Baumann N,McMahon JJ,Klingler E,Bocchi R,Kiss JZ,Bellone C,Silver DL,Jabaudon D
14-4875-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot to reveal that, in the developing mouse neocortex, ventricular zone progenitors become more hyperpolarized as they generate successive subtypes of neurons.
Thu Aug 23 00:00:00 UTC 2018
Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders.
Journal of neuroscience research
Ishizuka K,Tabata H,Ito H,Kushima I,Noda M,Yoshimi A,Usami M,Watanabe K,Morikawa M,Uno Y,Okada T,Mori D,Aleksic B,Ozaki N,Nagata KI
14-4875-82 was used in Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot to indicate that tightly regulated expression of migfilin is essential for neuronal development and that FBLIM1 disruption may be related to the phenotypes associated with ASD and related neurodevelopmental disorders.
Tue May 01 00:00:00 UTC 2018
Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo.
Scientific reports
Parigi SM,Czarnewski P,Das S,Steeg C,Brockmann L,Fernandez-Gaitero S,Yman V,Forkel M,Höög C,Mjösberg J,Westerberg L,Färnert A,Huber S,Jacobs T,Villablanca EJ
14-4875 was used in Flow cytometry/Cell sorting to indicate that Flt3L expands CHILPs in the bone marrow, which might be associated with specific inflammatory conditions.
Tue Jan 09 00:00:00 UTC 2018
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Nature immunology
Shan Q,Zeng Z,Xing S,Li F,Hartwig SM,Gullicksrud JA,Kurup SP,Van Braeckel-Budimir N,Su Y,Martin MD,Varga SM,Taniuchi I,Harty JT,Peng W,Badovinac VP,Xue HH
14-4875 was used in Flow cytometry/Cell sorting to show that Runx3-mediated Tcf7 repression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage deviation.
Tue Aug 01 00:00:00 UTC 2017
NFκB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality.
Proceedings of the National Academy of Sciences of the United States of America
Knudson KM,Pritzl CJ,Saxena V,Altman A,Daniels MA,Teixeiro E
14-4875 was used in Flow cytometry/Cell sorting to show that TCR/antigenic signals regulate the induction of a NFκB/Pim-1 feedback loop that controls expression of Eomes and thereby long-term maintenance of the memory pool.
Tue Feb 28 00:00:00 UTC 2017
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity.
Proceedings of the National Academy of Sciences of the United States of America
Chamoto K,Chowdhury PS,Kumar A,Sonomura K,Matsuda F,Fagarasan S,Honjo T
14487582 was used in flow cytometry to characterize mitochondrial changes in T cells due to PD-1 blockade therapy
Tue Jan 31 00:00:00 UTC 2017
A non-canonical function of Ezh2 preserves immune homeostasis.
EMBO reports
Vasanthakumar A,Xu D,Lun AT,Kueh AJ,van Gisbergen KP,Iannarella N,Li X,Yu L,Wang D,Williams BR,Lee SC,Majewski IJ,Godfrey DI,Smyth GK,Alexander WS,Herold MJ,Kallies A,Nutt SL,Allan RS
14-4875 was used in Flow cytometry/Cell sorting to identify a chromatin-independent function of enhancer of zeste 2 that impacts on the development of the immune system.
Sat Apr 01 00:00:00 UTC 2017
The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+ T Cells via SHIP-1.
Frontiers in immunology
Hope JL,Stairiker CJ,Spantidea PI,Gracias DT,Carey AJ,Fike AJ,van Meurs M,Brouwers-Haspels I,Rijsbergen LC,Fraietta JA,Mueller YM,Klop RC,Stelekati E,Wherry EJ,Erkeland SJ,Katsikis PD
14-4875 was used in Flow cytometry/Cell sorting to show that the proliferative effect of miR-155 on CD8+T cells is mediated by T-bet. T-bet levels in CTL were controlledin vivoby miR-155viaSH2 (Src homology 2)-containing inositol phosphatase-1 (SHIP-1), a known direct target of miR-155, and SHIP-1 directly downregulated T-bet.
Sat Jan 09 00:00:00 UTC 2021
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
PLoS pathogens
Danahy DB,Anthony SM,Jensen IJ,Hartwig SM,Shan Q,Xue HH,Harty JT,Griffith TS,Badovinac VP
14-4875-82 was used in Flow Cytometry to directly examine the impact of sepsis on tissue resident memory CD8+ T cells in mice.
Fri Sep 01 00:00:00 UTC 2017
NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury.
Journal of leukocyte biology
Hoegl S,Ehrentraut H,Brodsky KS,Victorino F,Golden-Mason L,Eltzschig HK,McNamee EN
14487582 was used in flow cytometry to elucidate the role of Tbet in acute lung injury
Wed Feb 01 00:00:00 UTC 2017
Meningeal retinoic acid contributes to neocortical lamination and radial migration during mouse brain development.
Biology open
Haushalter C,Schuhbaur B,Dollé P,Rhinn M
14-4875 was used in Immunohistochemistry to demonstrate that meninges are a source of extrinsic signals important for cortical development.
Wed Feb 15 00:00:00 UTC 2017
Meningeal retinoic acid contributes to neocortical lamination and radial migration during mouse brain development.
Biology open
Haushalter C,Schuhbaur B,Dollé P,Rhinn M
14-4875 was used in Immunohistochemistry to demonstrate that meninges are a source of extrinsic signals important for cortical development.
Wed Feb 15 00:00:00 UTC 2017
A dual-fluorescence reporter in the Eomes locus for live imaging and medium-term lineage tracing.
Genesis (New York, N.Y. : 2000)
Probst S,Daza RA,Bader N,Hummel JF,Weiß M,Tanriver Y,Hevner RF,Arnold SJ
14-4875 was used in Immunofluorescence in immunohistochemistry on frozen tissues to present a novel genetic tool for investigation of Eomes-dependent cell types by live imaging and lineage tracing.
Tue Aug 01 00:00:00 UTC 2017
A dual-fluorescence reporter in the Eomes locus for live imaging and medium-term lineage tracing.
Genesis (New York, N.Y. : 2000)
Probst S,Daza RA,Bader N,Hummel JF,Weiß M,Tanriver Y,Hevner RF,Arnold SJ
14-4875 was used in Immunofluorescence in immunohistochemistry on frozen tissues to present a novel genetic tool for investigation of Eomes-dependent cell types by live imaging and lineage tracing.
Tue Aug 01 00:00:00 UTC 2017
A dual-fluorescence reporter in the Eomes locus for live imaging and medium-term lineage tracing.
Genesis (New York, N.Y. : 2000)
Probst S,Daza RA,Bader N,Hummel JF,Weiß M,Tanriver Y,Hevner RF,Arnold SJ
14-4875 was used in Immunofluorescence in immunohistochemistry on frozen tissues to present a novel genetic tool for investigation of Eomes-dependent cell types by live imaging and lineage tracing.
Tue Aug 01 00:00:00 UTC 2017
IL-12 Influence mTOR to Modulate CD8+ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis.
International journal of medical sciences
Wang H,Li J,Han Q,Yang F,Xiao Y,Xiao M,Xu Y,Su L,Cui N,Liu D
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Mon May 21 00:00:00 UTC 2018
Active medulloblastoma enhancers reveal subgroup-specific cellular origins.
Nature
Lin CY,Erkek S,Tong Y,Yin L,Federation AJ,Zapatka M,Haldipur P,Kawauchi D,Risch T,Warnatz HJ,Worst BC,Ju B,Orr BA,Zeid R,Polaski DR,Segura-Wang M,Waszak SM,Jones DT,Kool M,Hovestadt V,Buchhalter I,Sieber L,Johann P,Chavez L,Gröschel S,Ryzhova M,Korshunov A,Chen W,Chizhikov VV,Millen KJ,Amstislavskiy V,Lehrach H,Yaspo ML,Eils R,Lichter P,Korbel JO,Pfister SM,Bradner JE,Northcott PA
Thu Feb 04 00:00:00 UTC 2016
Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Nature genetics
Broix L,Jagline H,Ivanova E,Schmucker S,Drouot N,Clayton-Smith J,Pagnamenta AT,Metcalfe KA,Isidor B,Louvier UW,Poduri A,Taylor JC,Tilly P,Poirier K,Saillour Y,Lebrun N,Stemmelen T,Rudolf G,Muraca G,Saintpierre B,Elmorjani A,Moïse M,Weirauch NB,Guerrini R,Boland A,Olaso R,Masson C,Tripathy R,Keays D,Beldjord C,Nguyen L,Godin J,Kini U,Nischké P,Deleuze JF,Bahi-Buisson N,Sumara I,Hinckelmann MV,Chelly J
14487582 was used in immunohistochemistry to demonstrate that missense mutations in NEDD4L result in periventricular nodular heterotopia associated with toe syndactyly, cleft palate, and neurodevelopmental delay
Tue Nov 01 00:00:00 UTC 2016
Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex.
Nature neuroscience
Wang L,Hou S,Han YG
14-4875 was used in Immunohistochemistry to demonstrate that SHH signaling in the human fetal neocortex may promote basal progenitor expansion and neocortical growth and folding.
Fri Jul 01 00:00:00 UTC 2016
Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion.
The Journal of experimental medicine
Hu Y,Kim JH,He K,Wan Q,Kim J,Flach M,Kirchhausen T,Vortkamp A,Winau F
14487582 was used in flow cytometry to study the role of TMEM16F in limiting T cell responses in mice infected with virus
Mon Nov 14 00:00:00 UTC 2016
Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fame RM,MacDonald JL,Dunwoodie SL,Takahashi E,Macklis JD
Wed Jun 15 00:00:00 UTC 2016
NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3.
Journal of immunology (Baltimore, Md. : 1950)
Hamblet CE,Makowski SL,Tritapoe JM,Pomerantz JL
14-4875 was used in Flow cytometry/Cell sorting to investigate the role of SPPL3 in murine NK cell biology.
Tue Mar 15 00:00:00 UTC 2016
The G protein-coupled receptor GPR157 regulates neuronal differentiation of radial glial progenitors through the Gq-IP3 pathway.
Scientific reports
Takeo Y,Kurabayashi N,Nguyen MD,Sanada K
14-4875 was used in Immunohistochemistry to show GPR157-Gq signaling at the primary cilia of RGPs is activated by the CSF and contributes to neurogenesis.
Wed May 04 00:00:00 UTC 2016
The G protein-coupled receptor GPR157 regulates neuronal differentiation of radial glial progenitors through the Gq-IP3 pathway.
Scientific reports
Takeo Y,Kurabayashi N,Nguyen MD,Sanada K
14-4875 was used in Immunohistochemistry to show GPR157-Gq signaling at the primary cilia of RGPs is activated by the CSF and contributes to neurogenesis.
Wed May 04 00:00:00 UTC 2016
Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto.
Scientific reports
Martínez Gómez JM,Periasamy P,Dutertre CA,Irving AT,Ng JH,Crameri G,Baker ML,Ginhoux F,Wang LF,Alonso S
14487582 was used in flow cytometry to describe the phenotypic and functional characterization of T cell subsets, B and NK cells in the fruit-eating bat Pteropus alecto
Thu Nov 24 00:00:00 UTC 2016
Retinoic Acid Differentially Regulates the Migration of Innate Lymphoid Cell Subsets to the Gut.
Immunity
Kim MH,Taparowsky EJ,Kim CH
14487582 was used in flow cytometry to discuss tissue tropisms of innate lymphoid cells
Tue Jul 21 00:00:00 UTC 2015
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
Immunity
Mackay LK,Wynne-Jones E,Freestone D,Pellicci DG,Mielke LA,Newman DM,Braun A,Masson F,Kallies A,Belz GT,Carbone FR
14-4875 was used in Flow cytometry/Cell sorting to indicate that the T-box TFs control the two cytokines, TGF-β and IL-15, which are pivotal for CD8(+)CD103(+) Trm cell development and survival.
Tue Dec 15 00:00:00 UTC 2015
mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.
The Journal of clinical investigation
Pollizzi KN,Patel CH,Sun IH,Oh MH,Waickman AT,Wen J,Delgoffe GM,Powell JD
14-4875 was used in Flow cytometry/Cell sorting to define specific roles for mTORC1 and mTORC2 in the specification of immune cell subsets.
Fri May 01 00:00:00 UTC 2015
PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness.
The Journal of experimental medicine
Yang M,Li D,Chang Z,Yang Z,Tian Z,Dong Z
14-4875 was used in Flow cytometry/Cell sorting to investigate the signals required to induce E4BP4 expression and its effects on NK cell development in mice.
Mon Feb 09 00:00:00 UTC 2015
Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation.
The Journal of experimental medicine
Dobenecker MW,Kim JK,Marcello J,Fang TC,Prinjha R,Bosselut R,Tarakhovsky A
14-4875 was used in Flow cytometry/Cell sorting to enable precise coupling of TCR specificity to lineage commitment.
Mon Mar 09 00:00:00 UTC 2015
The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis.
Genes & development
Miyazaki M,Miyazaki K,Chen S,Chandra V,Wagatsuma K,Agata Y,Rodewald HR,Saito R,Chang AN,Varki N,Kawamoto H,Murre C
14-4875 was used in Flow cytometry/Cell sorting to show that Id2 and Id3 suppress the development and expansion of innate variant follicular helper T cells.
Sun Feb 15 00:00:00 UTC 2015
The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment.
Aging cell
Nair S,Fang M,Sigal LJ
14-4875 was used in Flow cytometry/Cell sorting to describe age-related defects in NK cells including reduced proliferation, signs of immaturity, and dysregulated expression of activating and inhibitory receptors.
Wed Apr 01 00:00:00 UTC 2015
Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.
PLoS pathogens
Pascutti MF,Geerman S,Slot E,van Gisbergen KP,Boon L,Arens R,van Lier RA,Wolkers MC,Nolte MA
14-4875 was used in Flow cytometry/Cell sorting to study resolution of chronic viral infection through GITR-mediated co-stimulation enhancing CD8 T cell responses.
Sun Mar 01 00:00:00 UTC 2015
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.
PLoS pathogens
Gupta PK,Godec J,Wolski D,Adland E,Yates K,Pauken KE,Cosgrove C,Ledderose C,Junger WG,Robson SC,Wherry EJ,Alter G,Goulder PJ,Klenerman P,Sharpe AH,Lauer GM,Haining WN
14-4875 was used in Flow cytometry/Cell sorting to compare the expression of CD39 by CD8+ T cells from healthy donors and subjects with chronic viral infections.
Thu Oct 01 00:00:00 UTC 2015
PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pearce VQ,Bouabe H,MacQueen AR,Carbonaro V,Okkenhaug K
14-4875 was used in Flow cytometry/Cell sorting to investigate the effect of inhibition of the p110δ subunit of PI3Kδ on CD8(+) T cell responses to Listeria monocytogenes infection.
Thu Oct 01 00:00:00 UTC 2015
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Journal of immunology (Baltimore, Md. : 1950)
Buchan S,Manzo T,Flutter B,Rogel A,Edwards N,Zhang L,Sivakumaran S,Ghorashian S,Carpenter B,Bennett C,Freeman GJ,Sykes M,Croft M,Al-Shamkhani A,Chakraverty R
14-4875 was used in Flow cytometry/Cell sorting to study how CD27-mediated co-stimulation can synergise with co-inhibitory checkpoint blockade to switch off molecular programs for quiescence in exhausted T cell populations.
Thu Jan 01 00:00:00 UTC 2015
NKp46+ Innate Lymphoid Cells Dampen Vaginal CD8 T Cell Responses following Local Immunization with a Cholera Toxin-Based Vaccine.
PloS one
Luci C,Bekri S,Bihl F,Pini J,Bourdely P,Nouhen K,Malgogne A,Walzer T,Braud VM,Anjuère F
14-4875 was used in Flow cytometry/Cell sorting to show that vaginal NKp46+ Innate lymphoid cells dampen vaccine-induced CD8 T cell responses generated after local immunization with a Cholera Toxin-Based Vaccine.
Thu Jun 23 00:00:00 UTC 2016
Systematic profiling of spatiotemporal tissue and cellular stiffness in the developing brain.
Development (Cambridge, England)
Iwashita M,Kataoka N,Toida K,Kosodo Y
14-4875 was used in Immunofluorescence to investigate how tissue stiffness cannot be solely determined by the stiffness of the cells that constitute the tissue.
Wed Oct 01 00:00:00 UTC 2014
Differential requirement for Nfil3 during NK cell development.
Journal of immunology (Baltimore, Md. : 1950)
Seillet C,Huntington ND,Gangatirkar P,Axelsson E,Minnich M,Brady HJ,Busslinger M,Smyth MJ,Belz GT,Carotta S
14-4875 was used in Flow cytometry/Cell sorting to study how Nfil3 drives the formation of mature NK cells by inducing Eomes expression and reveal the differential requirements of NK cell subsets for Nfil3.
Sat Mar 15 00:00:00 UTC 2014
ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Zumwalde NA,Domae E,Mescher MF,Shimizu Y
14-4875 was used in Flow cytometry/Cell sorting to demonstrate that during CD8 T cell activation, the T cell clustering mechanism allows for continued proliferation of T cells, and regulates CD8 T cell effector function and differentiation.
Tue Oct 01 00:00:00 UTC 2013
T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Sandy AR,Chung J,Toubai T,Shan GT,Tran IT,Friedman A,Blackwell TS,Reddy P,King PD,Maillard I
14-4875 was used in Flow cytometry/Cell sorting to investigate parallel roles for Notch signaling in alloreactive CD4(+) and CD8(+) T cells that differ from past reports of Notch action and highlight the therapeutic potential of Notch inhibition in GVHD.
Sat Jun 01 00:00:00 UTC 2013
Low-affinity T cells are programmed to maintain normal primary responses but are impaired in their recall to low-affinity ligands.
Cell reports
Knudson KM,Goplen NP,Cunningham CA,Daniels MA,Teixeiro E
14-4875 was used in Flow cytometry/Cell sorting to demonstrate that distinct mechanisms drive effector/memory development in high- and low-affinity T-cells.
Thu Aug 15 00:00:00 UTC 2013
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
Nature immunology
Zhang N,Bevan MJ
14-4875 was used in Flow cytometry/Cell sorting to propose that TGF-β signaling controls the self-reactivity of peripheral T cells but that in the absence of TGF-β signals, an added trigger such as lymphopenia is needed to drive overt autoimmune disease.
Sun May 27 00:00:00 UTC 2012
Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mizuguchi R,Naritsuka H,Mori K,Mao CA,Klein WH,Yoshihara Y
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Immunofluorescence
Wed Jun 27 00:00:00 UTC 2012
Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mizuguchi R,Naritsuka H,Mori K,Mao CA,Klein WH,Yoshihara Y
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Immunofluorescence
Wed Jun 27 00:00:00 UTC 2012
Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunity.
Journal of immunology (Baltimore, Md. : 1950)
Li Q,Rao R,Vazzana J,Goedegebuure P,Odunsi K,Gillanders W,Shrikant PA
14-4875 was used in Flow cytometry/Cell sorting to indicate that judicious application of rapamycin can augment vaccine efficacy for chronic challenges.
Sun Apr 01 00:00:00 UTC 2012
CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Qui HZ,Hagymasi AT,Bandyopadhyay S,St Rose MC,Ramanarasimhaiah R,Ménoret A,Mittler RS,Gordon SM,Reiner SL,Vella AT,Adler AJ
Published figure using EOMES monoclonal antibody (Product # 14-4875-82) in Flow Cytometry
Sat Oct 01 00:00:00 UTC 2011
IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions.
Journal of immunology (Baltimore, Md. : 1950)
Marshall HD,Prince AL,Berg LJ,Welsh RM
Sun Aug 01 00:00:00 UTC 2010
