Bioss

EP3 Polyclonal Antibody

View all (16) PTGER3 antibodies

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-1876R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human EP3, amino acids 51-150.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and haematopoietic stem cells. CD172a acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. Ligand binding of CD172a to integrin-associated protein CD47, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. These then act as regulators of cellular function, through dephosphorylation of specific substrates. Ligation of CD172a with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Ep3 receptor; MGC141828; MGC141829; MGC27302; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; PGE2-R; pr; prostaglandin E receotor EP3 subtype 3 isoform; prostaglandin E receptor 3 (subtype EP3); prostaglandin E receptor EP3 subtype; Prostaglandin E2 receptor EP3 subtype; prostaglandin receptor (PGE-2); Prostanoid EP3 receptor

View more View less

Gene Aliases: EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3-VI; EP3e; PGE2-R; Pgerep3; PTGER3; Ptgerep3; Rep3; rEP3a; rEP3b

View more View less

UniProt ID: (Human) P43115, (Rat) P34980

View more View less

Entrez Gene ID: (Human) 5733, (Rat) 24929, (Mouse) 19218

View more View less

Function(s)
prostaglandin E receptor activity signal transducer activity G-protein coupled receptor activity prostaglandin receptor activity protein binding
Process(es)
fever generation G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration bicarbonate transport positive regulation of fever generation response to lipopolysaccharide positive regulation of urine volume desensitization of G-protein coupled receptor protein signaling pathway signal transduction negative regulation of cAMP biosynthetic process positive regulation of cAMP biosynthetic process positive regulation of neutrophil extravasation inflammatory response adenylate cyclase-activating G-protein coupled receptor signaling pathway female pregnancy cell death positive regulation of gene expression negative regulation of norepinephrine secretion intestine smooth muscle contraction urinary bladder smooth muscle contraction response to estradiol response to progesterone response to drug positive regulation of vasoconstriction positive regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of insulin secretion maternal process involved in parturition negative regulation of gastric acid secretion cellular response to lipopolysaccharide cellular response to interleukin-1 negative regulation of platelet aggregation negative regulation of potassium ion transmembrane transport response to salt negative regulation of calcium ion transmembrane transport negative regulation of gastrin-induced gastric acid secretion positive regulation of smooth muscle contraction involved in micturition cellular response to forskolin positive regulation of inhibitory G-protein coupled receptor phosphorylation negative regulation of circadian sleep/wake cycle, wakefulness positive regulation of myofibroblast contraction positive regulation of colon smooth muscle contraction positive regulation of gastric mucosal blood circulation prostaglandin receptor internalization negative regulation of forebrain neuron differentiation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support