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EPCAM Polyclonal Antibody

EPCAM Antibody in Immunocytochemistry (ICC/IF)

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EPCAM Antibody (21050-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using (Product # 21050-1-AP) (EPCAM antibody) at dilution of 1:100 and CoraLite488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

EPCAM Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EPCAM Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Product Image Gallery

Product Details

21050-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 32 publications 32 publications

Immunohistochemistry (IHC)

View 12 publications 12 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 14 publications 14 publications

Flow Cytometry (Flow)

Assay-dependent

View 2 publications 2 publications

ChIP assay (ChIP)

Assay-dependent

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 2 publications 2 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EPCAM Fusion Protein Ag15393 (24-264 aa encoded by BC014785)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QEECVCENY KLAVNCFVNN NRQCQCTSVG AQNTVICSKL AAKCLVMKAE MNGSKLGRRA KPEGALQNND GLYDPDCDES GLFKAKQCNG TSTCWCVNTA GVRRTDKDTE ITCSERVRTY WIIIELKHKA REKPYDSKSL RTALQKEITT RYQLDPKFIT SILYENNVIT IDLVQNSSQK TQNDVDIADV AYYFEKDVKG ESLFHSKKMD LTVNGEQLDL DPGQTLIYYV DEKAPEFSMQ GL (24-264 aa encoded by BC014785)

Target Information

Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is highly expressed in human carcinomas, and is a marker for tumors of epithelial lineage. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and many carcinoma types. Also, Ep-CAM reportedly distinguishes adenocarcinomas from pleural mesotheliomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Adenocarcinoma-associated antigen; CD326; Cell surface glycoprotein Trop-1; EGP; EGP314; Ep-CAM; Epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; hEGP314; human epithelial glycoprotein-2; KS 1/4 antigen; KSA; lymphocyte antigen 74; Major gastrointestinal tumor-associated protein GA733-2; mEGP314; membrane component, chromosome 4, surface marker (35kD glycoprotein); panepithelial glycoprotein 314; Protein 289A; Trop-1 protein; Tumor-associated calcium signal transducer 1

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Gene Aliases: CD326; DIAR5; EGP; EGP-2; EGP314; EGP40; Ep-CAM; EPCAM; EpCAM1; ESA; GA733-2; gp40; HNPCC8; KS1/4; KSA; Ly74; M1S2; M4S1; MIC18; MK-1; Tacsd1; TACSTD1; TROP1

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UniProt ID: (Human) P16422, (Mouse) Q99JW5

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Entrez Gene ID: (Human) 4072, (Mouse) 17075

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Function(s)

protein binding protein complex binding cadherin binding involved in cell-cell adhesion

Process(es)

ureteric bud development positive regulation of cell proliferation signal transduction involved in regulation of gene expression negative regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter stem cell differentiation cell-cell adhesion negative regulation of cell-cell adhesion mediated by cadherin positive regulation of cell motility positive regulation of stem cell proliferation

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EPCAM Polyclonal Antibody

EPCAM Antibody (21050-1-AP) in ICC/IF

Product Details

21050-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

ChIP assay (ChIP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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