Proteintech

EPHA2 Monoclonal Antibody (1A9C3)

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EPHA2 Antibody (66736-1-IG) in WB

Various lysates were subjected to SDS PAGE followed by western blot with 66736-1-Ig (EPHA2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours.

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Product Details

66736-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10,000

View 6 publications 6 publications

Flow Cytometry (Flow)

0.20 µg

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1A9C3

Immunogen

EPHA2 Fusion Protein Ag22566

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

EphA2 Promotes the Development of Cervical Cancer through the CXCL11/PD-L1 Pathway.

Journal of oncology

Zhao X,Liu J,Jin D,Ren C,Yang L,Zhu Y,Huang C,Ding L,Wu Z,Shen K,Zhang Z,Chen H,Wang N

Sat Dec 10 00:00:00 UTC 2022

Metabolic Reprogramming of Microglia Enhances Proinflammatory Cytokine Release through EphA2/p38 MAPK Pathway in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

Ma X,Zhang Y,Gou D,Ma J,Du J,Wang C,Li S,Cui H

Tue Jul 26 00:00:00 UTC 2022

EFNA4 promotes cell proliferation and tumor metastasis in hepatocellular carcinoma through a PIK3R2/GSK3β/β-catenin positive feedback loop.

Molecular therapy. Nucleic acids

Lin J,Zeng C,Zhang J,Song Z,Qi N,Liu X,Zhang Z,Li A,Chen F

Fri Sep 03 00:00:00 UTC 2021

EphA2 inhibits SRA01/04 cells apoptosis by suppressing autophagy via activating PI3K/Akt/mTOR pathway.

Archives of biochemistry and biophysics

Han J,Wang L,Lv H,Liu J,Dong Y,Shi L,Ji Q

Sat Oct 30 00:00:00 UTC 2021

2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ) inhibits cancer cell metastasis behavior of TNBC via suppressing EMT and VEGF.

Chemico-biological interactions

Zheng D,Wu Z,Han J,Guan Q,Li Z,Zuo D,Zhang W,Wu Y

Fri Sep 25 00:00:00 UTC 2020

Role of Nuclear Claudin-4 in Renal Cell Carcinoma.

International journal of molecular sciences

Owari T,Sasaki T,Fujii K,Fujiwara-Tani R,Kishi S,Mori S,Mori T,Goto K,Kawahara I,Nakai Y,Miyake M,Luo Y,Tanaka N,Kondoh M,Fujimoto K,Kuniyasu H

Fri Nov 06 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: Ephrin type-A receptor 2; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; soluble EPHA2 variant 1; Tyrosine-protein kinase receptor ECK

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Gene Aliases: ARCC2; CTPA; CTPP1; CTRCT6; ECK; EPHA2

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UniProt ID: (Human) P29317

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Entrez Gene ID: (Human) 1969

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Function(s)

transmembrane receptor protein tyrosine kinase activity ephrin receptor activity protein binding ATP binding cadherin binding involved in cell-cell adhesion

Process(es)

skeletal system development angiogenesis vasculogenesis osteoblast differentiation multicellular organism development intrinsic apoptotic signaling pathway in response to DNA damage regulation of lamellipodium assembly notochord formation viral process cell migration peptidyl-tyrosine phosphorylation neural tube development neuron differentiation keratinocyte differentiation osteoclast differentiation mammary gland epithelial cell proliferation regulation of cell adhesion mediated by integrin post-anal tail morphogenesis protein kinase B signaling regulation of blood vessel endothelial cell migration regulation of angiogenesis bone remodeling ephrin receptor signaling pathway axial mesoderm formation negative regulation of protein kinase B signaling notochord cell development cell chemotaxis branching involved in mammary gland duct morphogenesis lens fiber cell morphogenesis regulation of ERK1 and ERK2 cascade response to growth factor positive regulation of establishment of protein localization to plasma membrane activation of GTPase activity cell-cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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EPHA2 Monoclonal Antibody (1A9C3)

EPHA2 Antibody (66736-1-IG) in WB

Product Details

66736-1-IG

Western Blot (WB)

Flow Cytometry (Flow)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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