Proteintech

EPHX2 Polyclonal Antibody

EPHX2 Antibody in Immunocytochemistry (ICC/IF)

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EPHX2 Antibody (10833-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HEK-293 cells using 10833-1-AP (EPHX2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

EPHX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EPHX2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10833-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Chicken

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EPHX2 Fusion Protein Ag1283 (212-555 aa encoded by BC013874)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ELEKVTGIQ LLNTPAPLPT SCNPSDMSHG YVTVKPRVRL HFVELGSGPA VCLCHGFPES WYSWRYQIPA LAQAGYRVLA MDMKGYGESS APPEIEEYCM EVLCKEMVTF LDKLGLSQAV FIGHDWGGML VWYMALFYPE RVRAVASLNT PFIPANPNMS PLESIKANPV FDYQLYFQEP GVAEAELEQN LSRTFKSLFR ASDESVLSMH KVCEAGGLFV NSPEEPSLSR MVTEEEIQFY VQQFKKSGFR GPLNWYRNME RNWKWACKSL GRKILIPALM VTAEKDFVLV PQMSQHMEDW IPHLKRGHIE DCGHWTQMDK PTEVNQILIK WLDSDARNPP VVSKM (212-555 aa encoded by BC013874)

Target Information

This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.

ACS central science

Zhang J,Zhang M,Huo XK,Ning J,Yu ZL,Morisseau C,Sun CP,Hammock BD,Ma XC

Wed Mar 22 00:00:00 UTC 2023

Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.

ACS central science

Zhang J,Zhang M,Huo XK,Ning J,Yu ZL,Morisseau C,Sun CP,Hammock BD,Ma XC

Wed Mar 22 00:00:00 UTC 2023

Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPβ.

Biochimica et biophysica acta. Molecular basis of disease

Zhou Y,Wang XC,Wei JH,Xue HM,Sun WT,He GW,Yang Q

Sat Apr 01 00:00:00 UTC 2023

Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury.

International journal of biological sciences

Zhang J,Luan ZL,Huo XK,Zhang M,Morisseau C,Sun CP,Hammock BD,Ma XC

Wed Jan 04 00:00:00 UTC 2023

EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation.

Frontiers in oncology

Zhou Y,Li X,Guan A,Zhou H,Zhu Y,Wang R,Li R

Tue May 03 00:00:00 UTC 2022

EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation.

Frontiers in oncology

Zhou Y,Li X,Guan A,Zhou H,Zhu Y,Wang R,Li R

Tue May 03 00:00:00 UTC 2022

Adeno-associated virus-mediated in vivo suppression of expression of EPHX2 gene modulates the activity of paraventricular nucleus neurons in spontaneously hypertensive rats.

Biochemical and biophysical research communications

Zhu X,Li K,Gao Y

Sat May 28 00:00:00 UTC 2022

An advanced network pharmacology study to explore the novel molecular mechanism of Compound Kushen Injection for treating hepatocellular carcinoma by bioinformatics and experimental verification.

BMC complementary medicine and therapies

Lu S,Meng Z,Tan Y,Wu C,Huang Z,Huang J,Fu C,Stalin A,Guo S,Liu X,You L,Li X,Zhang J,Zhou W,Zhang X,Wang M,Wu J

Wed Mar 02 00:00:00 UTC 2022

Identification and validation of EPHX2 as a prognostic biomarker in hepatocellular carcinoma.

Molecular medicine reports

Zhan K,Bai Y,Liao S,Chen H,Kuang L,Luo Q,Lv L,Qiu L,Mei Z

Wed Sep 01 00:00:00 UTC 2021

Identification and validation of EPHX2 as a prognostic biomarker in hepatocellular carcinoma.

Molecular medicine reports

Zhan K,Bai Y,Liao S,Chen H,Kuang L,Luo Q,Lv L,Qiu L,Mei Z

Wed Sep 01 00:00:00 UTC 2021

Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase.

Archives of biochemistry and biophysics

Labitzke EM,Diani-Moore S,Rifkind AB

Sat Dec 01 00:00:00 UTC 2007

Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase.

Archives of biochemistry and biophysics

Labitzke EM,Diani-Moore S,Rifkind AB

Sat Dec 01 00:00:00 UTC 2007

Bioinformatics

Protein Aliases: Bifunctional epoxide hydrolase 2; CEH; cytosolic epoxide hydrolase; epoxide hydratase; epoxide hydrolase 2, cytoplasmic; epoxide hydrolase 2, cytosolic; epoxide hydrolase 2C; epoxide hydrolase, soluble; SEH; soluble epoxide hydrolase

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Gene Aliases: CEH; Eph2; EPHX2; SEH; sEP

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UniProt ID: (Human) P34913, (Mouse) P34914, (Rat) P80299

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Entrez Gene ID: (Human) 2053, (Mouse) 13850, (Rat) 65030

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Function(s)

magnesium ion binding epoxide hydrolase activity receptor binding toxic substance binding phosphatase activity 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity lipid phosphatase activity protein homodimerization activity catalytic activity hydrolase activity metal ion binding

Process(es)

prostaglandin production involved in inflammatory response lipid metabolic process inflammatory response metabolic process response to toxic substance positive regulation of gene expression dephosphorylation sensory perception of pain aromatic compound catabolic process cholesterol homeostasis linoleic acid metabolic process positive regulation of blood pressure stilbene catabolic process phospholipid dephosphorylation regulation of cholesterol metabolic process xenobiotic metabolic process cellular calcium ion homeostasis regulation of blood pressure drug metabolic process epoxygenase P450 pathway positive regulation of vasodilation reactive oxygen species metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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EPHX2 Polyclonal Antibody

EPHX2 Antibody (10833-1-AP) in ICC/IF

Product Details

10833-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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