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ERBB3 Polyclonal Antibody

ERBB3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ERBB3 Antibody (10369-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using 10369-1-AP (ERBB3 Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

10369-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ERBB3 Fusion Protein Ag0215 (88-331 aa encoded by BC002706)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LVAMNEFST LPLPNLRVVR GTQVYDGKFA IFVMLNYNTN SSHALRQLRL TQLTEILSGG VYIEKNDKLC HMDTIDWRDI VRDRDAEIVV KDNGRSCPPC HEVCKGRCWG PGSEDCQTLT KTICAPQCNG HCFGPNPNQC CHDECAGGCS GPQDTDCFAC RHFNDSGACV PRCPQPLVYN KLTFQLEPNP HTKYQYGGVC VASCPHNFVV DQTSCVRACP PDKMEVDKNG LKMCEPCGGL CPKAF (88-331 aa encoded by B C002706)

Target Information

ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents. The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6. 2kb mRNA which is translated into a 160/180 kDa glycoprotein. The ErbB3 gene encodes a transmembrane receptor tyrosine kinase due to alternative splicing and forms heterodimers with other EGF receptor family members that have kinase activity. Heterodimerization leads to the activation of pathways that lead to cell proliferation or differentiation. Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized. One ErbB3 isoform lacks the intermembrane region, is secreted outside the cell, and acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hepatitis B virus X protein increases LASP1 SUMOylation to stabilize HER2 and facilitate hepatocarcinogenesis.

International journal of biological macromolecules

You H,Yuan D,Li Q,Zhang N,Kong D,Yu T,Liu X,Liu X,Zhou R,Kong F,Zheng K,Tang R

Tue Jan 31 00:00:00 UTC 2023

CircEPSTI1 Promotes the Proliferation of HER2-Positive Breast Cancer Cells via circEPSTI1/miR-145/ERBB3 Axis.

Journal of oncology

Zhang Y,Tan D,Xie Y,Wu L,Wu S,Tang Y,Luo Y,Xiao X,Li X

Wed Sep 07 00:00:00 UTC 2022

NUF2 overexpression contributes to epithelial ovarian cancer progression via ERBB3-mediated PI3K-AKT and MAPK signaling axes.

Frontiers in oncology

Leng R,Meng Y,Sun X,Zhao Y

Wed Jan 11 00:00:00 UTC 2023

Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.

Cancers

Adediran S,Wang L,Khan MA,Guang W,Fan X,Dan H,Qi J,Jay SM,Carrier F,Hussain A

Fri Sep 23 00:00:00 UTC 2022

NOX4 Signaling Mediates Cancer Development and Therapeutic Resistance through HER3 in Ovarian Cancer Cells.

Cells

Liu WJ,Huang YX,Wang W,Zhang Y,Liu BJ,Qiu JG,Jiang BH,Liu LZ

Wed Jun 30 00:00:00 UTC 2021

ErbB1 and ErbB2 overexpression in patients with sinonasal inverted papilloma and inverted papilloma with squamous cell carcinoma in China.

Acta oto-laryngologica

Li H,Hu L,Zhang H,Wang D

Sun Dec 01 00:00:00 UTC 2019

Tumor suppressor role of miR-3622b-5p in ERBB2-positive cancer.

Oncotarget

Lu M,Wang T,He M,Cheng W,Yan T,Huang Z,Zhang L,Zhang H,Zhu W,Zhu Y,Liu P

Tue Apr 04 00:00:00 UTC 2017

Tumor suppressor role of miR-3622b-5p in ERBB2-positive cancer.

Oncotarget

Lu M,Wang T,He M,Cheng W,Yan T,Huang Z,Zhang L,Zhang H,Zhu W,Zhu Y,Liu P

Tue Apr 04 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: C-errB-3; human epidermal growth factor receptor 3; MDA BF 1; MGC88033; p180 ErbB3; p45 sErbB3; p85 sErbB3; Proto-oncogene-like protein c-ErbB-3; Receptor tyrosine-protein kinase erbB-3; Tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

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Gene Aliases: c-erbB-3; c-erbB3; ErbB-3; ERBB3; erbB3-S; HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3

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UniProt ID: (Human) P21860

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Entrez Gene ID: (Human) 2065

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Function(s)

protein tyrosine kinase activity transmembrane signaling receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding growth factor binding protein tyrosine kinase activator activity neuregulin binding identical protein binding protein homodimerization activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity

Process(es)

MAPK cascade endocardial cushion development negative regulation of cell adhesion signal transduction transmembrane receptor protein tyrosine kinase signaling pathway peripheral nervous system development heart development negative regulation of signal transduction Schwann cell differentiation phosphatidylinositol 3-kinase signaling regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation cranial nerve development ERBB2 signaling pathway wound healing regulation of cell proliferation negative regulation of neuron apoptotic process positive regulation of GTPase activity phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling negative regulation of secretion neuron apoptotic process positive regulation of protein tyrosine kinase activity positive regulation of calcineurin-NFAT signaling cascade extrinsic apoptotic signaling pathway in absence of ligand regulation of cell motility

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ERBB3 Polyclonal Antibody

ERBB3 Antibody (10369-1-AP) in IHC (P)

Product Details

10369-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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