Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
ERI1 Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
14592-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ERI1 Fusion Protein Ag6125 (1-349 aa encoded by BC035279)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEDPQSKEP AGEAVALALL ESPRPEGGEE PPRPSPEETQ QCKFDGQETK GSKFITSSAS DFSDPVYKEI AITNGCINRM SKEELRAKLS EFKLETRGVK DVLKKRLKNY YKKQKLMLKE SNFADSYYDY ICIIDFEATC EEGNPPEFVH EIIEFPVVLL NTHTLEIEDT FQQYVRPEIN TQLSDFCISL TGITQDQVDR ADTFPQVLKK VIDWMKLKEL GTKYKYSLLT DGSWDMSKFL NIQCQLSRLK YPPFAKKWIN IRKSYGNFYK VPRSQTKLTI MLEKLGMDYD GRPHCGLDDS KNIARIAVRM LQDGCELRIN EKMHAGQLMS VSSSLPIEGT PPPQMPHFRK (1-349 aa encoded by BC035279)
Target Information
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 3 ' exoribonuclease; 3' exoribonuclease; 3'-5' exonuclease ERI1; 3'-5' exoribonuclease 1; enhanced RNAi protein 1; enhanced RNAi three prime mRNA exonuclease homolog 1; Eri-1 homolog; HEXO; histone mRNA 3' end-specific exonuclease; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; protei; Protein 3'hExo; three prime histone mRNA exonuclease 1; three prime mRNA exonuclease 1
Gene Aliases: 3'EXO; 3'HEXO; 3110010F15Rik; eri-1; ERI1; HEXO; RGD1308378; THEX1
UniProt ID: (Human) Q8IV48, (Rat) Q5FVR4, (Mouse) Q7TMF2
Entrez Gene ID: (Human) 90459, (Rat) 361159, (Mouse) 67276
3'-5' exonuclease activity
rRNA binding
ribosome binding
metal ion binding
histone pre-mRNA stem-loop binding
3'-5'-exoribonuclease activity
nucleic acid binding
RNA binding
nuclease activity
exonuclease activity
hydrolase activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
gene silencing by RNA
rRNA 3'-end processing
histone mRNA catabolic process
DNA catabolic process, exonucleolytic
rRNA processing
nucleic acid phosphodiester bond hydrolysis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support