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Invitrogen
ERK1 Monoclonal Antibody (1E5)
Product Details
MA5-15896
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E5
Immunogen
Purified recombinant fragment of human MAPK3 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11151830
Product Specific Information
MA5-15896 targets MAPK3 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples.
The MA5-15896 immunogen is purified recombinant fragment of human MAPK3 expressed in E. Coli. .
MA5-15896 detects MAPK3 which has a predicted molecular weight of approximately 44kDa.
Target Information
MAPK3 (ERK1) is a serine/threonine kinase that is an important activator of p90, RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway. ERK1 is widely expressed and involved in the regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. Functionally, ERK1 is involved with a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. ERK1 is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms of ERK1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ERK; ERK-1; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAP kinase2; MAPK 1; MAPK 3; MAPK2; Microtubule-associated protein 2 kinase; mitogen-activated 3; mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; MNK1; p44 MAP kinase; p44-ERK1; p44-MAPK; pp42/MAP kinase
Gene Aliases: ERK-1; ERK1; ERT2; Esrk1; HS44KDAP; HUMKER1A; MAPK1; MAPK3; MNK1; Mtap2k; p44; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3
UniProt ID: (Human) P27361, (Rat) P21708, (Mouse) Q63844
Entrez Gene ID: (Human) 5595, (Rat) 50689, (Mouse) 26417
phosphotyrosine binding
protein serine/threonine kinase activity
MAP kinase activity
protein binding
ATP binding
kinase activity
phosphatase binding
scaffold protein binding
protein kinase activity
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
MAPK cascade
MAPK import into nucleus
positive regulation of protein phosphorylation
transcription, DNA-templated
protein complex assembly
protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
DNA damage induced protein phosphorylation
response to toxic substance
organ morphogenesis
phosphorylation
peptidyl-serine phosphorylation
sensory perception of pain
arachidonic acid metabolic process
BMP signaling pathway
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
regulation of stress-activated MAPK cascade
positive regulation of histone phosphorylation
positive regulation of histone acetylation
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
response to exogenous dsRNA
positive regulation of translation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of sequence-specific DNA binding transcription factor activity
cartilage development
regulation of cytoskeleton organization
lung morphogenesis
trachea formation
positive regulation of ERK1 and ERK2 cascade
interleukin-1-mediated signaling pathway
response to epidermal growth factor
cellular response to mechanical stimulus
caveolin-mediated endocytosis
regulation of Golgi inheritance
regulation of early endosome to late endosome transport
negative regulation of apolipoprotein binding
activation of MAPK activity
transcription initiation from RNA polymerase I promoter
cell cycle
axon guidance
fibroblast growth factor receptor signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
viral process
platelet activation
thyroid gland development
positive regulation of cyclase activity
positive regulation of telomere maintenance via telomerase
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
outer ear morphogenesis
thymus development
positive regulation of telomerase activity
Bergmann glial cell differentiation
face development
JAK-STAT cascade involved in growth hormone signaling pathway
cardiac neural crest cell development involved in heart development
ERK1 and ERK2 cascade
regulation of cellular response to heat
positive regulation of telomere capping
positive regulation of xenophagy
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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