Proteintech

ERLIN1 Polyclonal Antibody

ERLIN1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 15

ERLIN1 Antibody (17311-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 17311-1-AP (ERLIN1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

ERLIN1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ERLIN1 Antibody in Immunoprecipitation (IP)

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Product Details

17311-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ERLIN1 Fusion Protein Ag11279 (29-346 aa encoded by BC031791)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GHLAVYYRG GALLTSPSGP GYHIMLPFIT TFRSVQTTLQ TDEVKNVPCG TSGGVMIYID RIEVVNMLAP YAVFDIVRNY TADYDKTLIF NKIHHELNQF CSAHTLQEVY IELFDQIDEN LKQALQKDLN LMAPGLTIQA VRVTKPKIPE AIRRNFELME AEKTKLLIAA QKQKVVEKEA ETERKKAVIE AEKIAQVAKI RFQQKVMEKE TEKRISEIED AAFLAREKAK ADAEYYAAHK YATSNKHKLT PEYLELKKYQ AIASNSKIYF GSNIPNMFVD SSCALKYSDI RTGRESSLPS KEALEPSGEN VIQNKESTG (29-346 aa encoded by BC031791)

Target Information

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.

Molecular cell

van de Weijer ML,Krshnan L,Liberatori S,Guerrero EN,Robson-Tull J,Hahn L,Lebbink RJ,Wiertz EJHJ,Fischer R,Ebner D,Carvalho P

Thu Oct 15 00:00:00 UTC 2020

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.

Molecular cell

van de Weijer ML,Krshnan L,Liberatori S,Guerrero EN,Robson-Tull J,Hahn L,Lebbink RJ,Wiertz EJHJ,Fischer R,Ebner D,Carvalho P

Thu Sep 03 00:00:00 UTC 2020

Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease.

PLoS genetics

Li BT,Sun M,Li YF,Wang JQ,Zhou ZM,Song BL,Luo J

Sat Aug 01 00:00:00 UTC 2020

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells.

eLife

Tullett KM,Tan PS,Park HY,Schittenhelm RB,Michael N,Li R,Policheni AN,Gruber E,Huang C,Fulcher AJ,Danne JC,Czabotar PE,Wakim LM,Mintern JD,Ramm G,Radford KJ,Caminschi I,O'Keeffe M,Villadangos JA,Wright MD,Blewitt ME,Heath WR,Shortman K,Purcell AW,Nicola NA,Zhang JG,Lahoud MH

Wed Dec 02 00:00:00 UTC 2020

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation.

Cell

Llambi F,Wang YM,Victor B,Yang M,Schneider DM,Gingras S,Parsons MJ,Zheng JH,Brown SA,Pelletier S,Moldoveanu T,Chen T,Green DR

Thu Apr 07 00:00:00 UTC 2016

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation.

Cell

Llambi F,Wang YM,Victor B,Yang M,Schneider DM,Gingras S,Parsons MJ,Zheng JH,Brown SA,Pelletier S,Moldoveanu T,Chen T,Green DR

Thu Apr 07 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Band_7 23-211 Keo4 (Interim) similar to C.elegans protein C42C1.9; Endoplasmic reticulum lipid raft-associated protein 1; Erlin-1; OTTHUMP00000059425; OTTHUMP00000197867; Protein KE04; Protein KE04 homolog; SPFH domain family, member 1; SPFH domain-containing protein 1; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1

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Gene Aliases: 2810439N09Rik; C10orf69; C80197; Erlin-1; ERLIN1; KE04; KEO4; RGD1307058; SPFH1; SPG62

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UniProt ID: (Human) O75477, (Mouse) Q91X78

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Entrez Gene ID: (Human) 10613, (Rat) 293939, (Mouse) 226144

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Function(s)

protein binding cholesterol binding ubiquitin protein ligase binding

Process(es)

cholesterol metabolic process ER-associated ubiquitin-dependent protein catabolic process SREBP signaling pathway negative regulation of cholesterol biosynthetic process negative regulation of fatty acid biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ERLIN1 Polyclonal Antibody

ERLIN1 Antibody (17311-1-AP) in ICC/IF

Product Details

17311-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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