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Invitrogen
ERLIN2 Recombinant Rabbit Monoclonal Antibody (9T3M5)
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FIGURE: 1 / 3
ERLIN2 Antibody (MA5-42625) in IHC (P)
Immunohistochemistry analysis of ERLIN2 in paraffin-embedded mouse kidney. Samples were incubated with ERLIN2 Monoclonal antibody (Product # MA5-42625) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
MA5-42625
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
9T3M5
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Erlin-2 (O94905).
Conjugate
Form
Liquid
Concentration
1.2 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911766
Product Specific Information
Positive test controls include: 293T, PC-3, OVCAR3, C2C12. The target is usually found in the following locations: Endoplasmic reticulum membrane, Single-pass type II membrane protein.
Immunogen sequence: HLMLPFITSY KSVQTTLQTD EVKNVPCGTS GGVMIYFDRI EVVNFLVPNA VYDIVKNYTA DYDKALIFNK IHHELNQFCS VHTLQEVYIE LFDQIDENLK L
Target Information
ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) such as ITPR1. It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endoplasmic reticulum lipid raft-associated protein 2; endoplasmic reticulum lipid raft-associated protein 2 {ECO:0000250|UniProtKB:Q8BFZ9, ECO:0000312|EMBL:AAI68668.1}; Erlin-2; erlin-2 {ECO:0000250|UniProtKB:Q8BFZ9}; erlin2 {ECO:0000312|EMBL:AAI68668.1, ECO:0000312|RGD:1309010}; HGNC:1356; MGC87072; SPFH domain family, member 2; SPFH domain-containing protein 2; SPFH domain-containing protein 2 {ECO:0000250|UniProtKB:Q8BFZ9, ECO:0000312|EMBL:AAI68668.1}; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 {ECO:0000250|UniProtKB:Q8BFZ9}; UNQ2441
Gene Aliases: BC036333; C87251; C8orf2; Erlin-2; ERLIN2; NET32; RGD1309010; SPFH2; SPG18; UNQ2441/PRO5003/PRO9924
UniProt ID: (Human) O94905, (Mouse) Q8BFZ9, (Rat) B5DEH2
Entrez Gene ID: (Human) 11160, (Mouse) 244373, (Rat) 290823
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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