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Bioss
ERN2 Polyclonal Antibody
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Product Details
BS-6771R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ERN2, amino acids 465-550.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
ERN2 serine/threonine kinase or endoplasmic reticulum to nucleus signaling 2 protein is a human homologue of the yeast Ire1 gene product which plays a role in multiple facets of the ER stress response in mammalian cells. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endoplasmic reticulum (ER) to nucleus signalling 2; endoplasmic reticulum to nucleus signalling 2; Endoplasmic reticulum-to-nucleus signaling 2; ER to nucleus signalling 2; ern2; hIRE2p; inositol-requiring 1 (Yeast homologue); inositol-requiring 1 beta; Inositol-requiring protein 2; IRE1 beta; IRE1, S. cerevisiae, homolog of; Ire1-beta; IRE1b; mIre1; Serine/threonine-protein kinase/endoribonuclease IRE2
Gene Aliases: Ern1; ERN2; hIRE2p; Ire1; IRE1-BETA; IRE1b; IRE2; IRE2p
UniProt ID: (Human) Q76MJ5, (Mouse) Q9Z2E3
Entrez Gene ID: (Human) 10595, (Mouse) 26918, (Rat) 365363
magnesium ion binding
endonuclease activity
ribonuclease activity
protein serine/threonine kinase activity
ATP binding
nucleotide binding
catalytic activity
protein kinase activity
protein binding
kinase activity
bidentate ribonuclease III activity
transferase activity
transferase activity, transferring phosphorus-containing groups
hydrolase activity
metal ion binding
transcription, DNA-templated
mRNA processing
protein phosphorylation
rRNA catabolic process
apoptotic chromosome condensation
response to endoplasmic reticulum stress
negative regulation of transcription, DNA-templated
RNA phosphodiester bond hydrolysis
regulation of transcription, DNA-templated
apoptotic process
response to unfolded protein
cell cycle arrest
activation of JUN kinase activity
metabolic process
phosphorylation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
nucleic acid phosphodiester bond hydrolysis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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