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Invitrogen
ESRRG Recombinant Rabbit Monoclonal Antibody (4H7L11)
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FIGURE: 1 / 3
ESRRG Antibody (702406) in ICC/IF
Immunofluorescence analysis of Estrogen-related receptor gamma was performed using 70% confluent log phase SH-SY5Y cells treated with Retinoic acid (20 µM, 5 days). The cells were fixed with 4% paraformaldehyde for 5 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for overnight at room temperature. The cells were labeled with ESRRG Recombinant Rabbit Monoclonal Antibody (4H7L11) (Product # 702406) at 1:200 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-... View More
Product Details
702406
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
4H7L11
Immunogen
Peptides corresponding to human ESRRG (aa245-263, 318-333)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2663044
Product Specific Information
This antibody is predicted to react with Monkey, Sheep, Mouse
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Estrogen-related receptor gamma (ERRG, ERR3, NR3B3) is an orphan member of the nuclear hormone receptor superfamily. ERRG acts as a transcription activator in the absence of a bound ligand. It binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. ERRG also induces the expression of PERM1 in the skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781L1617; ERR gamma; ERR gamma-2; Estrogen receptor-related protein 3; estrogen-related receptor 3; Estrogen-related receptor gamma; FLJ16023; Nuclear receptor subfamily 3 group B member 3
Gene Aliases: ERR3; Errg; ERRG2; ERRgamma; ESRRG; KIAA0832; mKIAA0832; NR3B3
UniProt ID: (Human) P62508, (Mouse) P62509, (Rat) P62510
Entrez Gene ID: (Human) 2104, (Mouse) 26381, (Rat) 360896
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
steroid hormone receptor activity
retinoic acid receptor activity
steroid binding
protein binding
zinc ion binding
AF-2 domain binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
calmodulin binding
sequence-specific DNA binding
metal ion binding
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
multicellular organism development
intracellular receptor signaling pathway
steroid hormone mediated signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
transcription initiation from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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