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Proteintech
ESX1 Polyclonal Antibody
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Product Details
14657-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ESX1 Fusion Protein Ag6269 (1-406 aa encoded by BC053599)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MESLRGYTH SDIGYRSLAV GEDIEEVNDE KLTVTSLMAR GGEDEENTRS KPEYGTEAEN NVGTEGSVPS DDQDREGGGG HEPEQQQEEP PLTKPEQQQE EPPLLELKQE QEEPPQTTVE GPQPAEGPQT AEGPQPPERK RRRRTAFTQF QLQELENFFD ESQYPDVVAR ERLAARLNLT EDRVQVWFQN RRAKWKRNQR VLMLRNTATA DLAHPLDMFL GGAYYAAPAL DPALCVHLVP QLPRPPVLPV PPMPPRPPMV PMPPRPPIAP MPPMAPVPPG SRMAPVPPGP RMAPVPPWPP MAPVPPWPPM APVPTGPPMA RVPPGPPMAR VPPGPPMAPL PPGPPMAPLP PGPPMAPLPP GPPMAPLPPG PPMAPLPPRS HVPHTGLAPV HITWAPVINS YYACPFF (1-406 aa encoded by BC053599)
Target Information
Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain. During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion and the labyrinthine trophoblast of the chorioallantoic placenta. ESX1 can act like a transcriptional repressor to the human oncogene K-ras and treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ESX1-related protein; extraembryonic spermatogenesis homeobox 1; Extraembryonic, spermatogenesis, homeobox 1; extraembryonic, spermatogenesis, homeobox 1 homolog; Homeobox protein ESX1; RP3-513M9.1
Gene Aliases: ESX1; ESX1L; ESX1R; ESXR1; Spx1
UniProt ID: (Human) Q8N693
Entrez Gene ID: (Human) 80712, (Mouse) 13984
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
negative regulation of transcription, DNA-templated
regulation of cell cycle
labyrinthine layer morphogenesis
labyrinthine layer blood vessel development
blood vessel development
regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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