Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Bioss
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Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: chr2 synaptotagmin; Chr2Syt; E-Syt2; extended synaptotagmin like protein 2; extended synaptotagmin protein 2; Extended synaptotagmin-2; extended synaptotagmin-like protein 2; family with sequence similarity 62 (C2 domain containing), member B; family with sequence similarity 62, member B
Gene Aliases: 2410017M09Rik; 4921504I16Rik; CHR2SYT; D12Ertd551e; E-Syt2; ESYT2; FAM62B; KIAA1228; RGD1565705
UniProt ID: (Human) A0FGR8, (Mouse) Q3TZZ7
Entrez Gene ID: (Human) 57488, (Mouse) 52635, (Rat) 299488
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