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ETFDH Polyclonal Antibody

ETFDH Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ETFDH Antibody (11109-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 11109-1-AP) (ETFDH antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

ETFDH Antibody in Immunoprecipitation (IP)

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Product Details

11109-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ETFDH Fusion Protein Ag1568 (269-617 aa encoded by BC011890)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to ETFDH.

Immunogen sequence: QTYGIGLKE LWVIDEKNWK PGRVDHTVGW PLDRHTYGGS FLYHLNEGEP LVALGLVVGL DYQNPYLSPF REFQRWKHHP SIRPTLEGGK RIAYGARALN EGGFQSIPKL TFPGGLLIGC SPGFMNVPKI KGTHTAMKSG ILAAESIFNQ LTSENLQSKT IGLHVTEYED NLKNSWVWKE LYSVRNIRPS CHGVLGVYGG MIYTGIFYWI LRGMEPWTLK HKGSDFERLK PAKDCTPIEY PKPDGQISFD LLSSVALSGT NHEHDQPAHL TLRDDSIPVN RNLSIYDGPE QRFCPAGVYE FVPVEQGDGF RLQINAQNCV HCKTCDIKDP SQNINWVVPE GGGGPAYNGM (269-617 aa encoded by BC011890)

Target Information

Electron-transferring-flavoprotein dehydrogenase in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The protein is synthesized as a 67-kDa precursor which is targeted to mitochondria and processed in a single step to a 64-kDa mature form located in the mitochondrial membrane. Deficiency in electron-transferring-flavoprotein dehydrogenase have been demonstrated in some patients with type II glutaricacidemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism.

Cellular and molecular life sciences : CMLS

Peng MZ,Shao YX,Li XZ,Zhang KD,Cai YN,Lin YT,Jiang MY,Liu ZC,Su XY,Zhang W,Jiang XL,Liu L

Tue Jun 21 00:00:00 UTC 2022

Propofol Inhibits Proliferation and Augments the Anti-Tumor Effect of Doxorubicin and Paclitaxel Partly Through Promoting Ferroptosis in Triple-Negative Breast Cancer Cells.

Frontiers in oncology

Sun C,Liu P,Pei L,Zhao M,Huang Y

Fri Apr 15 00:00:00 UTC 2022

Propofol Inhibits Proliferation and Augments the Anti-Tumor Effect of Doxorubicin and Paclitaxel Partly Through Promoting Ferroptosis in Triple-Negative Breast Cancer Cells.

Frontiers in oncology

Sun C,Liu P,Pei L,Zhao M,Huang Y

Fri Apr 15 00:00:00 UTC 2022

Clinical, pathological and genetic features and follow-up of 110 patients with late-onset MADD: a single-center retrospective study.

Human molecular genetics

Wen B,Tang S,Lv X,Li D,Xu J,Olsen RKJ,Zhao Y,Li W,Wang T,Shao K,Zhao D,Yan C

Thu Mar 31 00:00:00 UTC 2022

CHIP control degradation of mutant ETF:QO through ubiquitylation in late-onset multiple acyl-CoA dehydrogenase deficiency.

Journal of inherited metabolic disease

Liu XY,Chen XJ,Zhao M,Wang ZQ,Chen HZ,Li HF,Wang CJ,Wu SF,Peng C,Yin Y,Fu HX,Lin MT,Yu L,Xiong ZQ,Wu ZY,Wang N

Mon Mar 01 00:00:00 UTC 2021

CHIP control degradation of mutant ETF:QO through ubiquitylation in late-onset multiple acyl-CoA dehydrogenase deficiency.

Journal of inherited metabolic disease

Liu XY,Chen XJ,Zhao M,Wang ZQ,Chen HZ,Li HF,Wang CJ,Wu SF,Peng C,Yin Y,Fu HX,Lin MT,Yu L,Xiong ZQ,Wu ZY,Wang N

Mon Mar 01 00:00:00 UTC 2021

Expression and significance of ETFDH in hepatocellular carcinoma.

Pathology, research and practice

Wu Y,Zhang X,Shen R,Huang J,Lu X,Zheng G,Chen X

Sun Dec 01 00:00:00 UTC 2019

ETFDH Mutations and Flavin Adenine Dinucleotide Homeostasis Disturbance Are Essential for Developing Riboflavin-Responsive Multiple Acyl-Coenzyme A Dehydrogenation Deficiency.

Annals of neurology

Xu J,Li D,Lv J,Xu X,Wen B,Lin P,Liu F,Ji K,Shan J,Li H,Li W,Zhao Y,Zhao D,Pok JY,Yan C

Thu Nov 01 00:00:00 UTC 2018

ETFDH Mutations and Flavin Adenine Dinucleotide Homeostasis Disturbance Are Essential for Developing Riboflavin-Responsive Multiple Acyl-Coenzyme A Dehydrogenation Deficiency.

Annals of neurology

Xu J,Li D,Lv J,Xu X,Wen B,Lin P,Liu F,Ji K,Shan J,Li H,Li W,Zhao Y,Zhao D,Pok JY,Yan C

Thu Nov 01 00:00:00 UTC 2018

ETFDH Mutations and Flavin Adenine Dinucleotide Homeostasis Disturbance Are Essential for Developing Riboflavin-Responsive Multiple Acyl-Coenzyme A Dehydrogenation Deficiency.

Annals of neurology

Xu J,Li D,Lv J,Xu X,Wen B,Lin P,Liu F,Ji K,Shan J,Li H,Li W,Zhao Y,Zhao D,Pok JY,Yan C

Thu Nov 01 00:00:00 UTC 2018

Significant clinical heterogeneity with similar ETFDH genotype in three Chinese patients with late-onset multiple acyl-CoA dehydrogenase deficiency.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Fu HX,Liu XY,Wang ZQ,Jin M,Wang DN,He JJ,Lin MT,Wang N

Fri Jul 01 00:00:00 UTC 2016

Significant clinical heterogeneity with similar ETFDH genotype in three Chinese patients with late-onset multiple acyl-CoA dehydrogenase deficiency.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Fu HX,Liu XY,Wang ZQ,Jin M,Wang DN,He JJ,Lin MT,Wang N

Fri Jul 01 00:00:00 UTC 2016

Molecular analysis of 51 unrelated pedigrees with late-onset multiple acyl-CoA dehydrogenation deficiency (MADD) in southern China confirmed the most common ETFDH mutation and high carrier frequency of c.250G>A.

Journal of molecular medicine (Berlin, Germany)

Wang ZQ,Chen XJ,Murong SX,Wang N,Wu ZY

Wed Jun 01 00:00:00 UTC 2011

Journal of molecular medicine (Berlin, Germany)

Wang ZQ,Chen XJ,Murong SX,Wang N,Wu ZY

Wed Jun 01 00:00:00 UTC 2011

Riboflavin-responsive lipid-storage myopathy caused by ETFDH gene mutations.

Journal of neurology, neurosurgery, and psychiatry

Wen B,Dai T,Li W,Zhao Y,Liu S,Zhang C,Li H,Wu J,Li D,Yan C

Mon Feb 01 00:00:00 UTC 2010

Riboflavin-responsive lipid-storage myopathy caused by ETFDH gene mutations.

Journal of neurology, neurosurgery, and psychiatry

Wen B,Dai T,Li W,Zhao Y,Liu S,Zhang C,Li H,Wu J,Li D,Yan C

Mon Feb 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; electron transferring flavoprotein dehydrogenase; Electron-transferring-flavoprotein dehydrogenase; ETF dehydrogenase; ETF-QO; ETF-ubiquinone oxidoreductase

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Gene Aliases: 0610010I20Rik; AV001013; ETFDH; ETFQO; MADD

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UniProt ID: (Human) Q16134, (Mouse) Q921G7

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Entrez Gene ID: (Human) 2110, (Rat) 295143, (Mouse) 66841

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Function(s)

electron-transferring-flavoprotein dehydrogenase activity electron carrier activity oxidoreductase activity oxidoreductase activity, oxidizing metal ions with flavin as acceptor metal ion binding quinone binding ubiquinone binding flavin adenine dinucleotide binding 4 iron, 4 sulfur cluster binding iron-sulfur cluster binding

Process(es)

response to oxidative stress biological_process electron transport chain fatty acid beta-oxidation using acyl-CoA dehydrogenase oxidation-reduction process transport respiratory electron transport chain

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ETFDH Polyclonal Antibody

ETFDH Antibody (11109-1-AP) in IHC (P)

Product Details

11109-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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