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Invitrogen
ETS2 Polyclonal Antibody
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FIGURE: 1 / 1
ETS2 Antibody (PA5-120275) in WB
Western blot analysis of ETS2 in extracts of Rat lung. Samples were incubated with ETS2 Polyclonal antibody (Product # PA5-120275) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 30s.
Product Details
PA5-120275
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 165-345 of human ETS2 (NP_005230.1).
Conjugate
Form
Liquid
Concentration
0.42 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913847
Product Specific Information
The target is usually found in the following locations: Nucleus.
Immunogen sequence: QMIKENQEKT EDQYEENSHL TSVPHWINSN TLGFGTEQAP YGMQTQNYPK GGLLDSMCPA STPSVLSSEQ EFQMFPKSRL SSVSVTYCSV SQDFPGSNLN LLTNNSGTPK DHDSPENGAD SFESSDSLLQ SWNSQSSLLD VQRVPSFESF EDDCSQSLCL NKPTMSFKDY IQERSDPVEQ G
Target Information
ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: avian erythroblastosis virus E26 (v-ets) oncogene homolog 2; E26 avian leukemia oncogene 2, 3' domain; protein C-ets-2
Entrez Gene ID: (Rat) 304063
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
glucocorticoid receptor binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
mesoderm development
cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
primitive streak formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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