Proteintech

EXOC1 Polyclonal Antibody

EXOC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

EXOC1 Antibody (11690-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas using 11690-1-AP (EXOC1 antibody) at dilution of 1:50 (under 10x lens).

EXOC1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11690-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 8 publications 8 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EXOC1 Fusion Protein Ag2303 (139-488 aa encoded by BC020650)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPGTMAEAE DLDGGTLSRQ HNCGTPLPVS SEKDMIRQMM IKIFRCIEPE LNNLIALGDK IDSFNSLYML VKMSHHVWTA QNVDPASFLS TTLGNVLVTV KRNFDKCISN QIRQMEEVKI SKKSKVGILP FVAEFEEFAG LAESIFKNAE RRGDLDKAYT KLIRGVFVNV EKVANESQKT PRDVVMMENF HHIFATLSRL KISCLEAEKK EAKQKYTDHL QSYVIYSLGQ PLEKLNHFFE GVEARVAQGI REEEVSYQLA FNKQELRKVI KEYPGKEVKK GLDNLYKKVD KHLCEEENLL QVVWHSMQDE FIRQYKHFEG LIARCYPGSG VTMEFTIQDI LDYCSSIAQS H (139-488 aa encoded by BC020650)

Target Information

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The exocyst complex is required for the trafficking and delivery of KCa3.1 to the basolateral membrane of polarized epithelia.

American journal of physiology. Cell physiology

Logue MJE,Farquhar RE,Eckhoff-Björngard Y,Cheung TT,Devor DC,McDonald FJ,Hamilton KL

Thu Jun 01 00:00:00 UTC 2023

Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells.

Nature nanotechnology

Saha T,Dash C,Jayabalan R,Khiste S,Kulkarni A,Kurmi K,Mondal J,Majumder PK,Bardia A,Jang HL,Sengupta S

Sat Jan 01 00:00:00 UTC 2022

Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells.

Nature nanotechnology

Saha T,Dash C,Jayabalan R,Khiste S,Kulkarni A,Kurmi K,Mondal J,Majumder PK,Bardia A,Jang HL,Sengupta S

Sat Jan 01 00:00:00 UTC 2022

EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice.

eLife

Osawa Y,Murata K,Usui M,Kuba Y,Le HT,Mikami N,Nakagawa T,Daitoku Y,Kato K,Shawki HH,Ikeda Y,Kuno A,Morimoto K,Tanimoto Y,Dinh TTH,Yagami KI,Ema M,Yoshida S,Takahashi S,Mizuno S,Sugiyama F

Tue May 11 00:00:00 UTC 2021

Shigella hijacks the exocyst to cluster macropinosomes for efficient vacuolar escape.

PLoS pathogens

Chang YY,Stévenin V,Duchateau M,Giai Gianetto Q,Hourdel V,Rodrigues CD,Matondo M,Reiling N,Enninga J

Sat Aug 01 00:00:00 UTC 2020

The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells.

American journal of physiology. Endocrinology and metabolism

Fujimoto BA,Young M,Carter L,Pang APS,Corley MJ,Fogelgren B,Polgar N

Sun Dec 01 00:00:00 UTC 2019

The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells.

American journal of physiology. Endocrinology and metabolism

Fujimoto BA,Young M,Carter L,Pang APS,Corley MJ,Fogelgren B,Polgar N

Sun Dec 01 00:00:00 UTC 2019

The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells.

The Journal of cell biology

Sáez JJ,Diaz J,Ibañez J,Bozo JP,Cabrera Reyes F,Alamo M,Gobert FX,Obino D,Bono MR,Lennon-Duménil AM,Yeaman C,Yuseff MI

Mon Jul 01 00:00:00 UTC 2019

EXO1 overexpression is associated with poor prognosis of hepatocellular carcinoma patients.

Cell cycle (Georgetown, Tex.)

Dai Y,Tang Z,Yang Z,Zhang L,Deng Q,Zhang X,Yu Y,Liu X,Zhu J

Fri Nov 08 00:00:00 UTC 2019

EXO1 overexpression is associated with poor prognosis of hepatocellular carcinoma patients.

Cell cycle (Georgetown, Tex.)

Dai Y,Tang Z,Yang Z,Zhang L,Deng Q,Zhang X,Yu Y,Liu X,Zhu J

Fri Nov 08 00:00:00 UTC 2019

EXO1 overexpression is associated with poor prognosis of hepatocellular carcinoma patients.

Cell cycle (Georgetown, Tex.)

Dai Y,Tang Z,Yang Z,Zhang L,Deng Q,Zhang X,Yu Y,Liu X,Zhu J

Fri Nov 08 00:00:00 UTC 2019

EXO1 overexpression is associated with poor prognosis of hepatocellular carcinoma patients.

Cell cycle (Georgetown, Tex.)

Dai Y,Tang Z,Yang Z,Zhang L,Deng Q,Zhang X,Yu Y,Liu X,Zhu J

Fri Nov 08 00:00:00 UTC 2019

A phosphoinositide conversion mechanism for exit from endosomes.

Nature

Ketel K,Krauss M,Nicot AS,Puchkov D,Wieffer M,Müller R,Subramanian D,Schultz C,Laporte J,Haucke V

Thu Jan 21 00:00:00 UTC 2016

A phosphoinositide conversion mechanism for exit from endosomes.

Nature

Ketel K,Krauss M,Nicot AS,Puchkov D,Wieffer M,Müller R,Subramanian D,Schultz C,Laporte J,Haucke V

Thu Jan 21 00:00:00 UTC 2016

Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics.

Scientific reports

Park SJ,Jeong J,Park YU,Park KS,Lee H,Lee N,Kim SM,Kuroda K,Nguyen MD,Kaibuchi K,Park SK

Tue Mar 03 00:00:00 UTC 2015

Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics.

Scientific reports

Park SJ,Jeong J,Park YU,Park KS,Lee H,Lee N,Kim SM,Kuroda K,Nguyen MD,Kaibuchi K,Park SK

Tue Mar 03 00:00:00 UTC 2015

Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics.

Scientific reports

Park SJ,Jeong J,Park YU,Park KS,Lee H,Lee N,Kim SM,Kuroda K,Nguyen MD,Kaibuchi K,Park SK

Tue Mar 03 00:00:00 UTC 2015

Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics.

Scientific reports

Park SJ,Jeong J,Park YU,Park KS,Lee H,Lee N,Kim SM,Kuroda K,Nguyen MD,Kaibuchi K,Park SK

Tue Mar 03 00:00:00 UTC 2015

Exocyst complex protein expression in the human placenta.

Placenta

Gonzalez IM,Ackerman WE,Vandre DD,Robinson JM

Tue Jul 01 00:00:00 UTC 2014

Exocyst complex protein expression in the human placenta.

Placenta

Gonzalez IM,Ackerman WE,Vandre DD,Robinson JM

Tue Jul 01 00:00:00 UTC 2014

Exocyst complex protein expression in the human placenta.

Placenta

Gonzalez IM,Ackerman WE,Vandre DD,Robinson JM

Tue Jul 01 00:00:00 UTC 2014

Exocyst complex protein expression in the human placenta.

Placenta

Gonzalez IM,Ackerman WE,Vandre DD,Robinson JM

Tue Jul 01 00:00:00 UTC 2014

Syntaxin 16 is a master recruitment factor for cytokinesis.

Molecular biology of the cell

Neto H,Kaupisch A,Collins LL,Gould GW

Sun Dec 01 00:00:00 UTC 2013

Syntaxin 16 is a master recruitment factor for cytokinesis.

Molecular biology of the cell

Neto H,Kaupisch A,Collins LL,Gould GW

Sun Dec 01 00:00:00 UTC 2013

Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation.

Retrovirology

Mukerji J,Olivieri KC,Misra V,Agopian KA,Gabuzda D

Fri Jun 22 00:00:00 UTC 2012

Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation.

Retrovirology

Mukerji J,Olivieri KC,Misra V,Agopian KA,Gabuzda D

Fri Jun 22 00:00:00 UTC 2012

Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation.

Retrovirology

Mukerji J,Olivieri KC,Misra V,Agopian KA,Gabuzda D

Fri Jun 22 00:00:00 UTC 2012

Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation.

Retrovirology

Mukerji J,Olivieri KC,Misra V,Agopian KA,Gabuzda D

Fri Jun 22 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: Exocyst complex component 1; Exocyst complex component Sec3; SEC3-like 1

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Gene Aliases: 2810407P21Rik; A730011E05Rik; BM-012; BM-102; EXOC1; SEC3; SEC3L1; SEC3P

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UniProt ID: (Human) Q9NV70, (Mouse) Q8R3S6

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Entrez Gene ID: (Human) 55763, (Mouse) 69940, (Rat) 305287

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Function(s)

protein binding phosphatidylinositol-4,5-bisphosphate binding GTP-Rho binding molecular_function

Process(es)

transport exocytosis Golgi to plasma membrane transport protein transport phosphatidylinositol-mediated signaling positive regulation of protein secretion exocyst localization regulation of macroautophagy

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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EXOC1 Polyclonal Antibody

EXOC1 Antibody (11690-1-AP) in IHC (P)

Product Details

11690-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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