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Invitrogen
EXOC4 Polyclonal Antibody
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FIGURE: 1 / 1
EXOC4 Antibody (PA5-88508) in WB
Western blot analysis of EXOC4 in extracts of various cell lines. Samples were incubated with EXOC4 Polyclonal antibody (Product # PA5-88508) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Product Details
PA5-88508
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human EXOC4 (NP_0685793)
Conjugate
Form
Liquid
Concentration
1.92 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804963
Product Specific Information
Immunogen sequence: MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA YEKCDRDLDE LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC KMLLHCKRDE LRKLWIEGIE HKHVLNLLDE IENIKQVPQK LEQCMASKHY LSATDMLVSA VESLEGPLLQ VEGLSDLRLE LHSKKMNLHL VLIDELHRHL YIKSTSRVVQ RNKEKGKISS LVKDASVPLI DVTNLPTPRK FLDTSHYSTA GSSSVREINL QDIKEDLELD PEENSTLFMG; Positive Samples: A-431, Jurkat, Mouse brain, Mouse thymus, Mouse liver, Rat brain
Target Information
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: augmenter of liver regeneration (ALR) pseudogene; Exocyst complex component 4; Exocyst complex component Sec8; MGC27170; REC8; rSec8; SEC8-like 1; secretory protein SEC8
Gene Aliases: ALR; C78892; EXOC4; KIAA1699; SEC8; SEC8L1; Sec8p
UniProt ID: (Human) Q96A65, (Rat) Q62824, (Mouse) O35382
Entrez Gene ID: (Human) 60412, (Rat) 116654, (Mouse) 20336
protein targeting to membrane
vesicle targeting
vesicle docking involved in exocytosis
chemical synaptic transmission
establishment of cell polarity
membrane biogenesis
oligodendrocyte differentiation
positive regulation of calcium-mediated signaling
regulation of protein transport
Golgi to transport vesicle transport
transport
exocytosis
protein transport
regulation of macroautophagy
paraxial mesoderm formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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