Proteintech

EXOC5 Polyclonal Antibody

EXOC5 Antibody in Immunocytochemistry (ICC/IF)

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EXOC5 Antibody (17593-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using EXOC5 antibody 17593-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

EXOC5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EXOC5 Antibody in Immunoprecipitation (IP)

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Product Details

17593-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EXOC5 Fusion Protein Ag11524 (359-708 aa encoded by BC041126)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SRSAMILQR YYDSKNHQKR SIGTGGIQDL KERIRQRTNL PLGPSIDTHG ETFLSQEVVV NLLQETKQAF ERCHRLSDPS DLPRNAFRIF TILVEFLCIE HIDYALETGL AGIPSSDSRN ANLYFLDVVQ QANTIFHLFD KQFNDHLMPL ISSSPKLSEC LQKKKEIIEQ MEMKLDTGID RTLNCMIRQM KHILAAEQKK TDFKPEDENN VLIQYTNACV KVCAYVRKQV EKIKNSMDGK NVDTVLMELG VRFHRLIYEH LQQYSYSCMG GMLAICDVAE YRKCAKDFKI PMVLHLFDTL HALCNLLVVA PDNLKQVCSG EQLANLDKNI LHSFVQLRAD YRSARLARHF S (359-708 aa encoded by BC041126)

Target Information

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis.

eLife

Zhao K,Matsunaga K,Mizuno K,Wang H,Okunishi K,Izumi T

Tue Feb 21 00:00:00 UTC 2023

The Exocyst Is Required for CD36 Fatty Acid Translocase Trafficking and Free Fatty Acid Uptake in Skeletal Muscle Cells.

Cells

Nakamura NK,Tokunaga DS,Ha HY,Polgar N

Sat Aug 06 00:00:00 UTC 2022

EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal.

Molecular cancer research : MCR

Li H,Fu X,Zhao J,Li C,Li L,Xia P,Guo J,Wei W,Zeng R,Wu J,Sun Y,Huang L,Wang X

Wed Jul 06 00:00:00 UTC 2022

EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal.

Molecular cancer research : MCR

Li H,Fu X,Zhao J,Li C,Li L,Xia P,Guo J,Wei W,Zeng R,Wu J,Sun Y,Huang L,Wang X

Wed Jul 06 00:00:00 UTC 2022

The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium.

Cell reports

Boukhalfa A,Roccio F,Dupont N,Codogno P,Morel E

Tue Apr 27 00:00:00 UTC 2021

Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.

The Journal of biological chemistry

Fujimoto BA,Young M,Nakamura N,Ha H,Carter L,Pitts MW,Torres D,Noh HL,Suk S,Kim JK,Polgar N

Fri Aug 27 00:00:00 UTC 2021

The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking.

Development (Cambridge, England)

Mao Y,Tu R,Huang Y,Mao D,Yang Z,Lau PK,Wang J,Ni J,Guo Y,Xie T

Fri Jun 28 00:00:00 UTC 2019

The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells.

American journal of physiology. Endocrinology and metabolism

Fujimoto BA,Young M,Carter L,Pang APS,Corley MJ,Fogelgren B,Polgar N

Sun Dec 01 00:00:00 UTC 2019

The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells.

American journal of physiology. Endocrinology and metabolism

Fujimoto BA,Young M,Carter L,Pang APS,Corley MJ,Fogelgren B,Polgar N

Sun Dec 01 00:00:00 UTC 2019

Downregulation of exocyst Sec10 accelerates kidney tubule cell recovery through enhanced cell migration.

Biochemical and biophysical research communications

Noh MR,Jang HS,Song DK,Lee SR,Lipschutz JH,Park KM,Kim JI

Mon Feb 05 00:00:00 UTC 2018

Downregulation of exocyst Sec10 accelerates kidney tubule cell recovery through enhanced cell migration.

Biochemical and biophysical research communications

Noh MR,Jang HS,Song DK,Lee SR,Lipschutz JH,Park KM,Kim JI

Mon Feb 05 00:00:00 UTC 2018

Insights into the ubiquitin-proteasome system of human embryonic stem cells.

Scientific reports

Saez I,Koyuncu S,Gutierrez-Garcia R,Dieterich C,Vilchez D

Tue Mar 06 00:00:00 UTC 2018

Insights into the ubiquitin-proteasome system of human embryonic stem cells.

Scientific reports

Saez I,Koyuncu S,Gutierrez-Garcia R,Dieterich C,Vilchez D

Tue Mar 06 00:00:00 UTC 2018

Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions.

PloS one

Fogelgren B,Polgar N,Lui VH,Lee AJ,Tamashiro KK,Napoli JA,Walton CB,Zuo X,Lipschutz JH

Thu Apr 07 00:00:00 UTC 2016

Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions.

PloS one

Fogelgren B,Polgar N,Lui VH,Lee AJ,Tamashiro KK,Napoli JA,Walton CB,Zuo X,Lipschutz JH

Thu Apr 07 00:00:00 UTC 2016

Exocyst complex protein expression in the human placenta.

Placenta

Gonzalez IM,Ackerman WE,Vandre DD,Robinson JM

Tue Jul 01 00:00:00 UTC 2014

Exocyst complex protein expression in the human placenta.

Placenta

Gonzalez IM,Ackerman WE,Vandre DD,Robinson JM

Tue Jul 01 00:00:00 UTC 2014

Exocyst complex protein expression in the human placenta.

Placenta

Gonzalez IM,Ackerman WE,Vandre DD,Robinson JM

Tue Jul 01 00:00:00 UTC 2014

Exocyst complex protein expression in the human placenta.

Placenta

Gonzalez IM,Ackerman WE,Vandre DD,Robinson JM

Tue Jul 01 00:00:00 UTC 2014

RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.

Cell

Bodemann BO,Orvedahl A,Cheng T,Ram RR,Ou YH,Formstecher E,Maiti M,Hazelett CC,Wauson EM,Balakireva M,Camonis JH,Yeaman C,Levine B,White MA

Fri Jan 21 00:00:00 UTC 2011

RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.

Cell

Bodemann BO,Orvedahl A,Cheng T,Ram RR,Ou YH,Formstecher E,Maiti M,Hazelett CC,Wauson EM,Balakireva M,Camonis JH,Yeaman C,Levine B,White MA

Fri Jan 21 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: 71 kDa component of rsec6/8 secretory complex; DKFZp666H126; Exocyst complex component 5; Exocyst complex component Sec10; hSec10; p71; p71 component of rsec6/8 secretory complex; SEC10-like 1

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Gene Aliases: AI447711; AI448003; EXOC5; Gm76; HSEC10; PRO1912; SEC10; SEC10L1; SEC10P

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UniProt ID: (Human) O00471, (Rat) P97878, (Mouse) Q3TPX4

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Entrez Gene ID: (Human) 10640, (Rat) 60627, (Mouse) 105504

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Function(s)

Ral GTPase binding protein N-terminus binding

Process(es)

exocytosis protein transport vesicle docking transport biological_process post-Golgi vesicle-mediated transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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EXOC5 Polyclonal Antibody

EXOC5 Antibody (17593-1-AP) in ICC/IF

Product Details

17593-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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