Proteintech

EXOSC10 Polyclonal Antibody

EXOSC10 Antibody in Immunocytochemistry (ICC/IF)

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EXOSC10 Antibody (11178-1-AP) in ICC/IF

Immunofluorescent analysis of NIH/3T3 cells using 11178-1-AP (EXOSC10 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

EXOSC10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EXOSC10 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11178-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EXOSC10 Fusion Protein Ag1666 (586-885 aa encoded by BC039901)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VAAGVKKSG PLPSAERLEN VLFGPHDCSH APPDGYPIIP TSGSVPVQKQ ASLFPDEKED NLLGTTCLIA TAVITLFNEP SAEDSKKGPL TVAQKKAQNI MESFENPFRM FLPSLGHRAP VSQAAKFDPS TKIYEISNRW KLAQVQVQKD SKEAVKKKAA EQTAAREQAK EACKAAAEQA ISVRQQVVLE NAAKKRERAT SDPRTTEQKQ EKKRLKISKK PKDPEPPEKE FTPYDYSQSD FKAFAGNSKS KVSSQFDPNK QTPSGKKCIA AKKIKQSVGN KSMSFPTGKS DRGFRYNWPQ R (586-885 aa encoded by BC039901)

Target Information

About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

NAT10 Drives Cisplatin Chemoresistance by Enhancing ac4C-Associated DNA Repair in Bladder Cancer.

Cancer research

Xie R,Cheng L,Huang M,Huang L,Chen Z,Zhang Q,Li H,Lu J,Wang H,Zhou Q,Huang J,Chen X,Lin T

Mon May 15 00:00:00 UTC 2023

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.

Life science alliance

Moll T,Odon V,Harvey C,Collins MO,Peden A,Franklin J,Graves E,Marshall JN,Dos Santos Souza C,Zhang S,Castelli L,Hautbergue G,Azzouz M,Gordon D,Krogan N,Ferraiuolo L,Snyder MP,Shaw PJ,Rehwinkel J,Cooper-Knock J

Sun Jan 01 00:00:00 UTC 2023

TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.

Nature communications

Matkovic R,Morel M,Lanciano S,Larrous P,Martin B,Bejjani F,Vauthier V,Hansen MMK,Emiliani S,Cristofari G,Gallois-Montbrun S,Margottin-Goguet F

Mon Jan 10 00:00:00 UTC 2022

Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling.

Development (Cambridge, England)

Ulmke PA,Xie Y,Sokpor G,Pham L,Shomroni O,Berulava T,Rosenbusch J,Basu U,Fischer A,Nguyen HP,Staiger JF,Tuoc T

Mon Feb 08 00:00:00 UTC 2021

Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling.

Development (Cambridge, England)

Ulmke PA,Xie Y,Sokpor G,Pham L,Shomroni O,Berulava T,Rosenbusch J,Basu U,Fischer A,Nguyen HP,Staiger JF,Tuoc T

Mon Feb 08 00:00:00 UTC 2021

Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.

RNA (New York, N.Y.)

Jiao AL,Perales R,Umbreit NT,Haswell JR,Piper ME,Adams BD,Pellman D,Kennedy S,Slack FJ

Fri Mar 01 00:00:00 UTC 2019

Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.

RNA (New York, N.Y.)

Jiao AL,Perales R,Umbreit NT,Haswell JR,Piper ME,Adams BD,Pellman D,Kennedy S,Slack FJ

Fri Mar 01 00:00:00 UTC 2019

Human Telomerase RNA Processing and Quality Control.

Cell reports

Tseng CK,Wang HF,Burns AM,Schroeder MR,Gaspari M,Baumann P

Tue Dec 15 00:00:00 UTC 2015

Human Telomerase RNA Processing and Quality Control.

Cell reports

Tseng CK,Wang HF,Burns AM,Schroeder MR,Gaspari M,Baumann P

Tue Dec 15 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: autoantigen PM-SCL; Autoantigen PM/Scl 2; Autoantigen PM/Scl 2 homolog; Exosome complex component 10; exosome component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl-100; Polymyositis/scleroderma autoantigen 100 kDa; Polymyositis/scleroderma autoantigen 2; Polymyositis/scleroderma autoantigen 2 homolog

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Gene Aliases: EXOSC10; p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p

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UniProt ID: (Human) Q01780, (Mouse) P56960

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Entrez Gene ID: (Human) 5394, (Mouse) 50912

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Function(s)

nucleotide binding 3'-5'-exoribonuclease activity exoribonuclease activity protein binding poly(A) RNA binding nucleic acid binding RNA binding catalytic activity nuclease activity exonuclease activity 5'-3' exoribonuclease activity 3'-5' exonuclease activity hydrolase activity

Process(es)

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay maturation of 5.8S rRNA nuclear-transcribed mRNA catabolic process rRNA processing dosage compensation by inactivation of X chromosome nuclear mRNA surveillance CUT catabolic process nuclear polyadenylation-dependent rRNA catabolic process histone mRNA catabolic process nuclear retention of unspliced pre-mRNA at the site of transcription RNA phosphodiester bond hydrolysis, exonucleolytic nucleobase-containing compound metabolic process RNA processing cellular metabolic process

Performance Guarantee

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EXOSC10 Polyclonal Antibody

EXOSC10 Antibody (11178-1-AP) in ICC/IF

Product Details

11178-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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