Proteintech

EXOSC3 Polyclonal Antibody

EXOSC3 Antibody in Immunocytochemistry (ICC/IF)

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EXOSC3 Antibody (15062-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed PC-3 cells using 15062-1-AP (EXOSC3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

EXOSC3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EXOSC3 Antibody in Immunoprecipitation (IP)

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Product Details

15062-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EXOSC3 Fusion Protein Ag7065 (1-275 aa encoded by BC002437)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAEPASVAA ESLAGSRARA ARTVLGQVVL PGEELLLPEQ EDAEGPGGAV ERPLSLNARA CSRVRVVCGP GLRRCGDRLL VTKCGRLRHK EPGSGSGGGV YWVDSQQKRY VPVKGDHVIG IVTAKSGDIF KVDVGGSEPA SLSYLSFEGA TKRNRPNVQV GDLIYGQFVV ANKDMEPEMV CIDSCGRANG MGVIGQDGLL FKVTLGLIRK LLAPDCEIIQ EVGKLYPLEI VFGMNGRIWV KAKTIQQTLI LANILEACEH MTSDQRKQIF SRLAES (1-275 aa encoded by B C002437)

Target Information

EXOSC3 is component of the exosome 3'->5' exoribonuclease complex and is required for the 3' processing of the 7S pre-RNA to the mature 5. 8S rRNA.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

TERRA stability is regulated by RALY and polyadenylation in a telomere-specific manner.

Cell reports

Savoca V,Rivosecchi J,Gaiatto A,Rossi A,Mosca R,Gialdini I,Zubovic L,Tebaldi T,Macchi P,Cusanelli E

Tue Apr 25 00:00:00 UTC 2023

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.

Life science alliance

Moll T,Odon V,Harvey C,Collins MO,Peden A,Franklin J,Graves E,Marshall JN,Dos Santos Souza C,Zhang S,Castelli L,Hautbergue G,Azzouz M,Gordon D,Krogan N,Ferraiuolo L,Snyder MP,Shaw PJ,Rehwinkel J,Cooper-Knock J

Sun Jan 01 00:00:00 UTC 2023

ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity.

Neurobiology of disease

An H,Litscher G,Watanabe N,Wei W,Hashimoto T,Iwatsubo T,Buchman VL,Shelkovnikova TA

Sat Jan 01 00:00:00 UTC 2022

Integrator is a genome-wide attenuator of non-productive transcription.

Molecular cell

Lykke-Andersen S,Žumer K,Molska EŠ,Rouvière JO,Wu G,Demel C,Schwalb B,Schmid M,Cramer P,Jensen TH

Thu Feb 04 00:00:00 UTC 2021

The RNA exosome shapes the expression of key protein-coding genes.

Nucleic acids research

Wu M,Karadoulama E,Lloret-Llinares M,Rouviere JO,Vaagensø CS,Moravec M,Li B,Wang J,Wu G,Gockert M,Pelechano V,Jensen TH,Sandelin A

Fri Sep 04 00:00:00 UTC 2020

The RNA exosome contributes to gene expression regulation during stem cell differentiation.

Nucleic acids research

Lloret-Llinares M,Karadoulama E,Chen Y,Wojenski LA,Villafano GJ,Bornholdt J,Andersson R,Core L,Sandelin A,Jensen TH

Fri Nov 30 00:00:00 UTC 2018

The RNA exosome contributes to gene expression regulation during stem cell differentiation.

Nucleic acids research

Lloret-Llinares M,Karadoulama E,Chen Y,Wojenski LA,Villafano GJ,Bornholdt J,Andersson R,Core L,Sandelin A,Jensen TH

Fri Nov 30 00:00:00 UTC 2018

Affinity Purification of the RNA Degradation Complex, the Exosome, from HEK-293 Cells.

Bio-protocol

Domanski M,LaCava J

Thu Apr 20 00:00:00 UTC 2017

Affinity Purification of the RNA Degradation Complex, the Exosome, from HEK-293 Cells.

Bio-protocol

Domanski M,LaCava J

Thu Apr 20 00:00:00 UTC 2017

A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans.

Nucleic acids research

Kalisiak K,Kuliński TM,Tomecki R,Cysewski D,Pietras Z,Chlebowski A,Kowalska K,Dziembowski A

Tue Feb 28 00:00:00 UTC 2017

Relationships between PROMPT and gene expression.

RNA biology

Lloret-Llinares M,Mapendano CK,Martlev LH,Lykke-Andersen S,Jensen TH

Tue Oct 25 00:00:00 UTC 2016

Relationships between PROMPT and gene expression.

RNA biology

Lloret-Llinares M,Mapendano CK,Martlev LH,Lykke-Andersen S,Jensen TH

Tue Oct 25 00:00:00 UTC 2016

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.

Nature communications

Boczonadi V,Müller JS,Pyle A,Munkley J,Dor T,Quartararo J,Ferrero I,Karcagi V,Giunta M,Polvikoski T,Birchall D,Princzinger A,Cinnamon Y,Lützkendorf S,Piko H,Reza M,Florez L,Santibanez-Koref M,Griffin H,Schuelke M,Elpeleg O,Kalaydjieva L,Lochmüller H,Elliott DJ,Chinnery PF,Edvardson S,Horvath R

Thu Jul 03 00:00:00 UTC 2014

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.

Nature communications

Thu Jul 03 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Exosome complex component RRP40; exosome complex exonuclease RRP40; Exosome component 3; hRrp40p; p10; Ribosomal RNA-processing protein 40; RP11-3J10.8

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Gene Aliases: 2310005D06Rik; AI593501; bA3J10.7; CGI-102; EXOSC3; hRrp-40; p10; PCH1B; RRP40; Rrp40p

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UniProt ID: (Human) Q9NQT5, (Mouse) Q7TQK4

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Entrez Gene ID: (Human) 51010, (Rat) 313243, (Mouse) 66362

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Function(s)

3'-5'-exoribonuclease activity RNA binding exoribonuclease activity protein binding molecular_function nuclease activity exonuclease activity 5'-3' exoribonuclease activity hydrolase activity

Process(es)

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay DNA deamination isotype switching positive regulation of isotype switching CUT catabolic process nuclear polyadenylation-dependent rRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription polyadenylation-dependent snoRNA 3'-end processing regulation of mRNA stability

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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EXOSC3 Polyclonal Antibody

EXOSC3 Antibody (15062-1-AP) in ICC/IF

Product Details

15062-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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