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Invitrogen
EXOSC3 Polyclonal Antibody
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FIGURE: 1 / 1
EXOSC3 Antibody (PA5-88182) in WB
Western blot analysis of EXOSC3 in extracts of various cell lines. Samples were incubated with EXOSC3 Polyclonal antibody (Product # PA5-88182) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Product Details
PA5-88182
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human EXOSC3 (NP_0571262)
Conjugate
Form
Liquid
Concentration
1.42 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804723
Product Specific Information
Immunogen sequence: MAEPASVAAE SLAGSRARAA RTVLGQVVLP GEELLLPEQE DAEGPGGAVE RPLSLNARAC SRVRVVCGPG LRRCGDRLLV TKCGRLRHKE PGSGSGGGVY WVDSQQKRYV PVKGDHVIGI VTAKSGDIFK VDVGGSEPAS LSYLSFEGAT KRNRPNVQVG DLIYGQFVVA NKDMEPEMVC IDSCGRANGM GVIGQDGLLF KVTLGLIRKL LAPDCEIIQE VGKLYPLEIV FGMNGRIWVK AKTIQQTLIL ANILEACEHM TSDQRKQIFS RLAES; Positive Samples: A-431, HeLa, U-87MG, Raji, SGC-7901, Mouse brain, Rat brain; Cellular Location: Cytoplasm, Nucleus, nucleolus
Target Information
EXOSC3 is component of the exosome 3'->5' exoribonuclease complex and is required for the 3' processing of the 7S pre-RNA to the mature 5. 8S rRNA.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Exosome complex component RRP40; exosome complex exonuclease RRP40; Exosome component 3; hRrp40p; p10; Ribosomal RNA-processing protein 40; RP11-3J10.8
Gene Aliases: 2310005D06Rik; AI593501; bA3J10.7; CGI-102; EXOSC3; hRrp-40; p10; PCH1B; RRP40; Rrp40p
UniProt ID: (Human) Q9NQT5, (Mouse) Q7TQK4
Entrez Gene ID: (Human) 51010, (Rat) 313243, (Mouse) 66362
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
rRNA processing
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U4 snRNA 3'-end processing
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
DNA deamination
isotype switching
positive regulation of isotype switching
CUT catabolic process
nuclear polyadenylation-dependent rRNA catabolic process
nuclear polyadenylation-dependent tRNA catabolic process
nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription
polyadenylation-dependent snoRNA 3'-end processing
regulation of mRNA stability
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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